WHO Classification of Tumours of the Digestive System

'WHO Classification of Tumours of the Digestive System: Fourth Edition' is an authoritative and concise reference book providing an international standard for oncologists and pathologists. Indispensable as a guide for use in the design of studies monitoring response to therapy and clinical outcome. This book also provides user-friendly algorithmic approaches to the diagnosis of the major tumours of the digestive tract. Diagnostic criteria, pathological features, and associated genetic alterations are described in a strictly disease-oriented manner. Sections on all recognized neoplasms and their variants include: new ICD-O codes; incidence; age and sex distribution; location; clinical signs and symptoms; pathology; genetics; and predictive factors. This publication has been prepared by more than 100 authors, originating from 22 countries. It contains approximately 700 colour photographs, together with numerous tables, figures and more than 3, 700 references.

Table of contents

1 Diagnostic terms revisited Premalignant lesions of the digestive system Nomenclature and classification of neuroendocrine neoplasms of the digestive system 2 Tumours of the oesophagus WHO and TNM classifications Squamous cell carcinoma Adenocarcinoma Neuroendocrine neoplasms Lymphoma Mesenchymal tumours Secondary tumours and melanoma 3 Tumours of the oesophagogastric junction Adenocarcinoma 4 Tumours of the stomach WHO and TNM classifications Gastric carcinoma Hereditary diffuse gastric cancer Neuroendocrine neoplasms Lymphoma Mesenchymal tumours Secondary tumours 5 Tumours of the ampullary region WHO and TNM classifications Adenomas and other premalignant neoplastic lesions Invasive adenocarcinoma Neuroendocrine neoplasms 6 Tumours of the small intestine WHO and TNM classifications Carcinoma Neuroendocrine neoplasms B-cell lymphoma T-cell lymphoma Mesenchymal tumours Secondary tumours 7 Tumours of the appendix WHO and TNM classifications Adenocarcinoma Neuroendocrine neoplasms Miscellaneous tumours 8 Tumours of the colon and rectum WHO and TNM classifications Carcinoma Familial adenomatous polyposis Lynch syndrome MUTYH-associated polyposis Serrated polyps and serrated polyposis Juvenile polyposis Peutz-Jeghers syndrome Cowden syndrome Neuroendocrine neoplasms B-cell lymphoma Mesenchymal tumours 9 Tumours of the anal canal WHO and TNM classifications Tumours of the anal canal 10 Tumours of the liver and intrahepatic bile ducts WHO and TNM classifications Focal nodular hyperplasia and hepatocellular adenoma Hepatocellular carcinoma Intrahepatic cholangiocarcinoma Combined hepatocellular-cholangiocarcinoma Hepatoblastoma Mucinous cystic neoplasms Lymphoma Mesenchymal tumours Secondary tumours Diagnostic algorithms 11 Tumours of the gallbladder and extrahepatic bile ducts WHO and TNM classifications Carcinoma Neuroendocrine neoplasms Mesenchymal tumours Lymphoma Secondary tumours and melanoma 12 Tumours of the pancreas WHO and TNM classifications Ductal adenocarcinoma Ductal adenocarcinoma variants and mixed neoplasms Serous neoplasms Mucinous cystic neoplasms Intraductal neoplasms Acinar cell neoplasms Pancreatoblastoma Neuroendocrine neoplasms Solid-pseudopapillary neoplasm Mesenchymal tumours Lymphoma Secondary tumours Diagnostic algorithms v Contributors Sources of charts and photographs References Subject index