Synthesis and Chemistry of Agrochemicals Series VIII

This book will be a continuation in the series of Synthesis and Chemistry of Agrochemicals. The focus of this volume is the translation of pesticidal activity from the lab to the greenhouse to the field. The book will cover the chemistry, ADMET and biochemistry research lending a better understanding of the issues involved with loss in activity going from lab assays to greenhouse and field. The second topic covered is synthesis of agrochemicals. This topic will address the good ideas that never made it to products, chemistry work done in the field of agriculture that was based on a good hypothesis yet never made it to a product. The chapters will cover insecticide, herbicide, fungicide and specialty products.

Contents
Preface
Chapter 1. Innovation Opportunities in the Crop Protection Industry , Ann Orth, George Theodoridis, and John Lyga
Tools and Methods to Assess Translation Factors
Chapter 2. Physical Property Requirements of Agrochemicals , Stephen F. Donovan
Chapter 3. Early Stage Assessment of Metabolic Stability In Planta , Roobina I. Baloch, Carla N. Yerkes, Gerrit J. Deboer, and Jeffrey R. Gilbert
Target-site to Laboratory Translation
Chapter 4. Antagonism of the GABA Receptor of Dieldrin-Resistant Houseflies by Fipronil and Its Analogues , Yoshihisa Ozoe, Shigekazu Ishikawa, Soichiro Tomiyama, Fumiyo Ozoe, Toshinori Kozaki, and Jeffrey G. Scott
Chapter 5. Thiamethoxam - A Neonicotinoid Precursor Converted to Clothianidin in Insects and Plants , Peter Jeschke and Ralf Nauen
Chapter 6. Thiamethoxam: High Affinity Binding and Unusual Mode of Interference with Other Neonicotinoids at Aphid Membranes , Hartmut Kayser, Henning Wellmann, Connie Lee, Arnaud Decock, Marilyne Gomes, Ben Cheek, Rob Lind, Markus Baur, Joerg Hattenscheiler, and Peter Maienfisch
Chapter 7. Discovery of Insecticidal Cyanine Dyes , Robert N. Henrie II, Thomas Cullen, Benjamin Dugan, Larry Zhang, Yanli Deng, Sandra F. Simpson, Bruce Black, Franz Schuler, and Seong Jae Yu
Chapter 8. The Crocacins A and D - Novel Natural Products as Leads for Agrochemicals , Patrick J. Crowley, Christopher R. A. Godfrey, and Russell Viner
Chapter 9. A Structure-Based Design Approach to Plant Selective 4-Hydroxyphenylpyruvate Dioxygenase Inhibitors , Debra L. Camper and Marshall H. Parker
Laboratory to Field Translation
Chapter 10. Fungicidal Properties of Acivicin and Its Derivatives , Hans-Georg Brunner, Phillippe Chemla, Marcus R. Dobler, Anthony C. O'Sullivan, Paul Pachlatko, Christian Pillonel, and Daniel Stierli
Chapter 11. Factors Involved in the Field Translation of a Class of Mitochondrial Qi Inhibitor Fungicides , W. John Owen, Yelena Adelfinskaya, Zoltan Benko, Christian T. Schobert
Chapter 12. Discovery of 3-arylpyrimidin-2,4-diones as GABA-gated Chloride Channel Insecticides: Translation from Target-Site to Field , John W. Lyga, Syed F. Ali, Lyle P. Kinne, F. Larry Marek, Mark A. Wusaty, Charles A. Staetz, and James Willut
Chapter 13. 2,4-Diaminoquinazoline Insecticides -- Elizabeth G. Rowley, Thomas G. Cullen, John A. Dixson, Sayed ElMarakby, Louis V. LaFrance, Saroj Sehgel, and Dennis Warkentin

Solving and Evaluating Field Efficacy .
Chapter 14. New Termiticides Necessitate Changes in Efficacy Testing: A Case Study of Fipronil , Chris J. Peterson, Terence L. Wagner, Thomas G. Shelton, and Joe E. Mulrooney
Overcoming Translation, New Pesticide Discoveries
Chapter 15. 2-Acylimino-3-Phenylthiazolines: A New Family of Bleaching Herbicides , Yuzuru Sanemitsu, Shinichi Kawamura, Junichi Satoh, Tadasi Katayama, and Shunichi Hashimoto
Chapter 16. The Discovery of Proquinazid, a New and Potent Powdery Mildew Control Agent , Thomas P. Selby, Charlene G. Sternberg, James F. Bereznak, Reed A. Cotes, and Eric A. Marshall
Chapter 17. The Novel Mode of Action of Anthranilic Diamide Insecticides - Ryanodine Receptor Activationn , Daniel Cordova, Eric A. Benner, Matthew D. Sacher, James J. Rauh, Jeffrey S. Sopa, George P. Lahm, Thomas P. Selby, Thomas M. Stevenson, Lindsey Flexner, Steven Gutteridge, Daniel F. Rhoades, Lihong Wu, Rejane M. Smith, Yong Tao
Chapter 18. Phthalic Acid Diamides Activate Insect Ryanodine Receptors -- Peter Lummen, Ulrich Ebbinghaus-Kintscher, Christian Funke, Rudiger Fisher, Takao Musaki, Noriaki Yasokawa, and Masanori Tohnishi

Authors, editors, and contributors

Edited by John W. Lyga, Research Fellow, FMC Corporation and
George Theodoritis, Pipeline Development Director, FMC Corporation.

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