Sepsis Codex

Offering a global, multidisciplinary perspective on this life-threatening medical emergency, The Sepsis Codex provides a concise yet comprehensive look at a complex topic. Nearly 20% of global deaths are attributed to sepsis annually, nearly half of which are in children under the age of five, with low-resource settings being disproportionately affected. A “one size fits all” approach is not sufficient to meet individual patients’ needs, instead requiring a therapeutic approach that considers different ages, predisposing factors, genetic traits, and more. This cutting-edge resource brings you up to date with recent medical advances in this challenging area.

PART I: INTRODUCTION
1 Sepsis: Past, Present, and Futured Lessons From COVID-19
José-Artur Paiva and Jordi Rello
2 Sepsis Definitions: A Historical Perspective
Javier Perez-Fernandez, Arlene C. Torres, and Paola Perez
3 The Epidemiology of Sepsis
Jamila Hedjal
PART II: BASIC CONCEPTS
4 Sepsis Pathophysiology
Jorge Hidalgo, Maria Jimena Aleman, Luisa Cruz and Allyson Hidalgo-Morazan
5 Sepsis and Microcirculation
Carlos Enrique A. Orellana Jimenez
6 Genetics and Sepsis
Gabriela Alvarado
PART III: DIAGNOSIS AND MONITORING
7 Early Detection and Screening
Márcio Borges Sá and Rafael Zaragoza Crespo
8 Diagnosis and Monitoring of Sepsis
Pietro Arina and Mervyn Singer
9 Sepsis: Molecular Diagnostics and Biomarkers
John Lyons and Craig Coopersmith
10 Hemodynamic Monitoring: Current Practice and New Perspectives
Christopher Lai and Jean-Louis Teboul
11 Point of Care Ultrasound in the Management of Sepsis
Saad Mahdy, Ahmed F. Hegazy and Tharawt Aisa
12 New Approaches and Understanding of Sepsis
Vanessa Fonseca-Ferrer, Sulimar Morales-Colón, Luis Gerena-Montano, William
Rodríguez-Cintrón, and Gloria M. Rodríguez-Vega
13 Sepsis Quality Indicators in the Emergency Department
Luis Antonio Gorordo-Delsol and Graciela Merinos-Sánchez
PART IV: TREATMENT
14 Sepsis Treatment: Fluids
Michaël Mekeirele, Domien Vanhonacker and Manu L. N. G. Malbrain
15 Vasopressor Therapy in Septic Shock
Rajesh Chandra Mishra, Sharmili Sinha, Reena Shah, Ahsan Ahmed and Ahsina Jahan Lopa
16 Mechanical Ventilation in Sepsis
Carlos Sánchez, Orlando Pérez-Nieto and Eder Zamarrón
17 Extracorporeal Membrane Oxygenation for the Support of Patients With Refractory Septic Shock
Jose Alfonso Rubio Mateo-Sidron
18 Antimicrobials in the Management of Sepsis
Judith Jacobi
19 Kidney Support in Sepsis
Javier Maynar, Helena Barrasa, Alex Martin and Fernando Fonseca
20 Hematological Support in Sepsis
Zulmi Aranda, Gerhaldine Morazan and Allyson Hidalgo
21 Specific Treatment of Focus Control in Sepsis
Xavier Guirao, Montserrat Juvany, Clara Centeno and Josep Maria Badia
22 Sepsis Adjunctive Therapies
Javier Perez-Fernandez and Paola Perez
23 Glycemic Control and Stress Ulcer Prophylaxis
Janice L. Zimmerman
24 Nutrition in Sepsis
Victor Sanchez Nava

PART V: SPECIAL SETTINGS
25 Fever in Intensive Care Units
Kazuaki Atagi
26 Sepsis--In the Era of Antimicrobial Resistance
Rajesh Chandra Mishra, Sharmili Sinha, Reena Shah, Ahsan Ahmed and Ahsina Jahan Lopa
27 Factors Underlying Racial and Gender Disparities in Sepsis Management
Ryoung-Eun Ko and Gee Young Suh
28 Sepsis in Special Populations
Marie Baldisseri, Laura S. Johnson, Michael Mazzei and Mary Jane Reed
29 Comprehensive Management of Sepsis in Pediatrics
Elisabeth Esteban, Juan Carlos de Carlos, Juan Ignacio Sánchez and Javier Gil Anton
30 Maternal Sepsis
Luis Antonio Gorordo-Delsol, Graciela Merinos- Sánchez, Lucina Nieves-Torres and Jeanette Zúñiga Escorza
PART VI: SPECIAL CONSIDERATIONS
31 Role of Preventive Measures in Sepsis
Jorge Sinclair, Jorge E. Sinclair De Frías and Lorenzo Olivero
32 Value of the Protocolization and Sepsis Performance Improvement Program in Early Identification
Carlos Sanchez
33 Long-Term Sequelae of Sepsis
Ahmed Taha
PART VII: FUTURE OUTLOOK
34 New Diagnostic and Therapeutic Perspectives
Juan Carlos Ruiz-Rodríguez, Luis Chiscano-Camón, Erika-Paola Plata Menchaca and Ricard Ferrer
35 Artificial Intelligence in Sepsis
Michiel Schinkel, Ketan Paranjape, Prabath W. B. Nanayakkara and W. Joost Wiersinga

Marcio Borges

Affiliations and Expertise

Associate Professor of Infectious Disease Balearic Islands University; Coordinator, Multidisciplinary Sepsis Unit, Critical Care Medicine, Son Llatzer University Hospital, Palma de Mallorca, Spain

Jorge Hidalgo

Dr. Jorge Hidalgo is a Professor of Critical Care and the Head of the Division of Critical Care at Karl Heusner Memorial Hospital in Belize, Central America. He is the President Elect of the World Federation of Societies of Critical Care and Intensive Care Medicine. He has won several awards with the highest recognition and the Director of the very prestigious ACP Review Course hosted by the Paraguay Society of Internal Medicine. Due to his outstanding contribution to the Society of Critical Care Medicine he received the Presidential Citation Award. And Global Safar Award, becoming the First Latin American Intensivist to get this Nomination. He is involved in numerous congresses and a well-recognized international speaker.

Affiliations and Expertise

Professor of Critical Care and the Head of the Division of Critical Care, Karl Heusner Memorial Hospital in Belize, Central America. President Elect, World Federation of Societies of Critical Care and Intensive Care Medicine.

Javier Perez-Fernandez

Dr. Javier Perez-Fernandez serves as Medical Director of the Critical Care Services at Baptist Hospital of Miami. He is a Clinical Associate Professor of Medicine at Florida International University, Herbert Wertheim College of Medicine and Professor Pulmonary and Critical Care Medicine at Larkin University, Miami-Dade Florida. He is the Secretary-General of the World Federation of Intensive Care. Dr. Perez-Fernandez manages a large group of critical care physicians, South Florida Critical Care Services, overseeing the operations of seven ICUs with over 350 beds. He has been a regional and national recognized leader during the COVID-19 pandemic with multiple TV and media appearances and consulting services for several national and international organizations. He has been directly involved in the development of Rapid Response Teams, technology implementation and “open ICU” models. He has lectured worldwide and author of many original publications with the Society of Critical Care Medicine.

Affiliations and Expertise

Medical Director, Critical Care Services Baptist Hospital of Miami, Florida, USA

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