Principles of Population Genetics

This text introduces the principles of genetics and statistics that are relevant to population studies, and examines the forces affecting genetic variation from the molecular to the organismic level. Included are descriptions of molecular methods, as well as explanations of the relevant estimation theory using actual data.

Genetic and Phenotypic Variation
Organisation of Genetic Variation
Random Genetic Drift
Mutation and the Neutral Theory
Darwinian Selection
Inbreeding, Population Subdivision, and Migration
Molecular Population Genetics
Evolutionary Quantitative Genetics
Population Genomics
Human Population Genetics

DANIEL L. HARTL is Higgins Professor of Biology at Harvard University, USA. He has been honoured with the Samuel Weiner Outstanding Scholar Award and Medal, the Medal of the Stazione Zoologica Anton Dohrn, and is an elected member of the National Academy of Sciences and the American Academy of Arts and Sciences. In addition to more than 300 scientific articles, Hartl has authored or co-authored 24 books.

ANDREW G. CLARK is Professor of Population Genetics at Cornell University, USA. His research focuses on the genetic basis of adaptive variation in natural populations, with emphasis on quantitative modeling of phenotypes as networks of interacting genes. He was elected Fellow of the American Association for the Advancement of Science in 1994, and serves on review panels for the NIH, NSF, and the Max Planck Society. He is also on the Advisory Council for the National Human Genome Research Institute.


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Description
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This text introduces the principles of genetics and statistics that are relevant to population studies, and examines the forces affecting genetic variation from the molecular to the organismic level. Included are descriptions of molecular methods, as well as explanations of the relevant estimation theory using actual data.


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Contents
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Genetic and Phenotypic Variation
Organisation of Genetic Variation
Random Genetic Drift
Mutation and the Neutral Theory
Darwinian Selection
Inbreeding, Population Subdivision, and Migration
Molecular Population Genetics
Evolutionary Quantitative Genetics
Population Genomics
Human Population Genetics


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Authors
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DANIEL L. HARTL is Higgins Professor of Biology at Harvard University, USA. He has been honoured with the Samuel Weiner Outstanding Scholar Award and Medal, the Medal of the Stazione Zoologica Anton Dohrn, and is an elected member of the National Academy of Sciences and the American Academy of Arts and Sciences. In addition to more than 300 scientific articles, Hartl has authored or co-authored 24 books.

ANDREW G. CLARK is Professor of Population Genetics at Cornell University, USA. His research focuses on the genetic basis of adaptive variation in natural populations, with emphasis on quantitative modeling of phenotypes as networks of interacting genes. He was elected Fellow of the American Association for the Advancement of Science in 1994, and serves on review panels for the NIH, NSF, and the Max Planck Society. He is also on the Advisory Council for the National Human Genome Research Institute.

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