Nuclear Cardiac Imaging: Principles and Applications

Nuclear cardiac imaging refers to cardiac radiological diagnostic techniques performed with the aid of radiopharmaceuticals, which are perfused into the myocardium as markers. These imaging studies provide a wide range of information about the heart, including the contractility of the heart, the amount of blood supply to the heart and whether parts of the heart muscle are alive or dead. This is essential information for cardiologists, and nuclear imaging has become an increasingly important part of the cardiologist's armamentarium. Chapters in Nuclear Cardiac Imaging cover historical, technical and physiological considerations, diagnosis and prognosis, conditions other than Coronary Artery Disease (CAD), advanced cardiac imaging, and challenges and opportunities. New to the sixth edition are key point summaries at the start of each chapter, clinical cases with videos, and a question and answer chapter on practical issues. This volume is ideal for nuclear cardiologists in training and nuclear clinicians alike who are searching for quick answers to important clinical and technical questions.

• Over 450 high-quality images supplement concise text for quick answers to important clinical and technical questions
• Highlights advances in cardiac imaging including hybrid imaging, cardiovascular molecular imaging, and the use of artificial intelligence
• Addresses challenges for nuclear cardiology including physician certification and lab accreditation, cost-effectiveness of imaging, guidelines and appropriate use criteria, and radiation considerations

Section I. Historical, Technical and Physiological Considerations
1. Nuclear Cardiology: History and Milestones- Barry Zaret
2. Radiation physics- James Galt
3. SPECT and PET Instrumentation- James Galt and Ernest Garcia
4. Kinetics of Conventional and New Cardiac Radiotracers- Ran Klein
5. Radionuclide Angiography: Planar and Tomographic- Steven Port
6. Gated SPECT MPI: Imaging Protocols and Acquisition; Processing and Quantitation- Milena Henzlova
7. Image Artifacts- William Van Decker
Section II. Diagnosis and Risk Assessment
8. Regulation of Myocardial Blood Flow: Henry Gewirtz
9. How to measure Myocardial Blood Flow by PET?- Heinrich Schelbert
10. How to measure Myocardial Blood flow by SPECT?- Terrence Ruddy
11. Treadmill Exercise Testing- Gregory Thomas
12. Pharmacological Stress Testing- Effie Andrikopoulou, Ami Iskandrian, Fadi Hage
13. SPECT MPI in Diagnosis/Risk Assessment- Rami Doukky
14. SPECT MPI for Risk Assessment in special groups (DM, Kidney transplant, Liver transplant, Asymptomatic, Obese)- Alberto Cuocolo
15. SPECT MPI for Risk Assessment before non-cardiac surgery- Lawrence Phillips
16. Evaluation of patients with Chest Pain in the Emergency Department- Jamieson Bourque
17. Role of PET (Perfusion and MBF) in Diagnosis and Risk Assessment - Rob Beanlands
18. Nuclear Imaging in women- Viviany Taqueti
19. Myocardial Viability Assessment by Nuclear Techniques- Vasken Dilsizian
Section III. Role of Nuclear Imaging Beyond CAD
20. Imaging dyssynchrony- Alessia Gimelli
21. Imaging Myocardial Innervation by SPECT and PET- Mark Travin
22. Imaging sarcoid heart disease- Paco Bravo
23. Imaging Amyloid heart disease- Panithaya Chareonthaitawee
24. Imaging infections of valves and devices- Thomas Schindler
25. Imaging cardiac and vascular inflammation- Mehran Sadeghi and Sina Tavakoli
26. Imaging in Heart Failure including those with devices and post cardiac transplant- Prem Soman
Section IV. Advances in Nuclear Cardiac Imaging
27. Evolving role of CT, cMR and echo in CAD- Jeroen BAx
28. Hybrid Imaging: SPECT/CTA, PET/MR and SPECT Calcium Score: when and why?- Philipp Kaufmann and Ronny Buechel
29. Artificial Intelligence and nuclear imaging- Piotr Slomka
30. Nuclear Imaging in patients with serious arrhythmias- Saurabh Malhotra
31. Nuclear Imaging in patients with HIV- Mouaz Al-Mallah
32. Nuclear Imaging in cardio-oncology- Raymond Russell and Matt Harinstein
33. Nuclear Imaging in patients with congenital heart diseases- Sharmila Dorbala and Sara Partington
Section V. Challenges for Nuclear Cardiology
34. Physician Certification and Lab Accreditation- Robert Hendel
35. ACC/AHA/ESC Nuclear Guidelines and Appropriate Use Criteria- Timothy Christian
36. Nuclear Cardiology Report generation- Wael Aljaroudi
37. Radiation Considerations in imaging- Andrew J Einstein
38. Statistics in Nuclear imaging- Charity Morgan
39. Nuclear Imaging in Developing Countries- Amalia Peix and Diana Paez
Section VI. Overview
40. Ask the Experts- Ami E. Iskandrian, Fadi G. Hage, Pradeep Bhambhvani, Ernest V. Garcia
Atlas Chapter 40: Self-Assessment

Edited by Ami E. Iskandrian, Professor Emeritus, Division of Cardiology, University of Alabama at Birmingham, and Edited by Fadi G. Hage, Professor of Medicine, University of Alabama at Birmingham

Ami E. Iskandrian, MD, MACC, MASNC is Professor Emeritus, Division of Cardiology, Department of Medicine, Heersink School of Medicine, The University of Alabama at Birmingham. He is the Editor-in-Chief, Journal of Nuclear Cardiology.

Fadi G. Hage, MD, MASNC, FACC is Professor, Division of Cardiology, Department of Medicine, Heersink School of Medicine, The University of Alabama at Birmingham. He is the Chief of Cardiology at the Birmingham VA Medical Center and the Director of Nuclear Cardiology at the University of Alabama at Birmingham.

Contributors:

Alberto Cuocolo, University of Naples Federico II, Italy

Amalia Peix, Institute of Cardiology and Cardiovascular Surgery, La Habana, Cuba

Andrew J Einstein, Columbia University Irving Medical Center

Barry Zaret, Yale School of Medicine

Bavo Paco, Perelman School of Medicine, University of Pennsylvania

Büchel Ronny, University Hospital Zurich

Charity J Morgan, University of Alabama

Diana Paez, International Atomic Energy Agency (IAEA)

Efstathia Andrikopoulou, University of Alabama at Birmingham

Eliana Reyes, King's College London

Ernest V Garcia, Emory University

Gregory Thomas, University of California, Irvine

Heinrich R. Schelbert, University of California, Los Angeles

Henry Gewirtz, Massachusetts General Hospital

James Galt, Emory University

Jamieson M. Bourque, University of Virginia Health

Jeroen Bax, Leiden University, Netherlands

Keiichiro Yoshinga, National Institute for Quantum Science and Technology

Lawrence Phillips, New York University Langone Health

Mark Travin, Albert Einstein College of Medicine

Mehran Sadeghi, Yale School of Medicine

Milena Henzlova, Mt. Sinai Hospital

Mouaz Al-Mallah, Houston Methodist Hospital

Panithaya Chareonthaitawee, Mayo Clinic College of Medicine

Philipp A Kaufmann, University Hospital Zurich

Piotr Slomka, Cedars-Sinai Medical Center

Pradeep Bhambhvani, University of Alabama at Birmingham

Prem Soman, University of Pittsburgh Medical Center

Rami Doukky, Rush University Medical Center

Raymond Russell, Lifespan Cardiovascular Institute, Rhode Island Hospital

Rob Beanlands, University of Ottawa Heart Institute

Robert Hendel, Tulane University School of Medicine

Salvadore Borges-Neto, Duke University School of Medicine

Saurabh Malhotra, John H. Stroger, Jr. Hospital, Provident Hospital

Sharmila Dorbala, Brigham and Women's Hospital, Boston

Terrence Ruddy, University of Ottawa Heart Institute

Thomas H Schindler, Washington University

Timothy Christian, Jacobi Medical Center

Vasken Dilsizian, University of Maryland School of Medicine

Viviany Taqueti, Brigham and Women's Hospital

William A VanDecker, Lewis Katz School of Medicine, Temple University

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