Maternal-Fetal and Neonatal Endocrinology: Physiology, Pathophysiology, and Clinical Management
Maternal-Fetal and Neonatal Endocrinology: Physiology, Pathophysiology, and Clinical Management systematically examines the normal and abnormal endocrinology of the pregnant and lactating female and of the fetus and neonate. This reference volume expands coverage of specific disorders and diseases beyond the current endocrinology content on the market, which in most cases has a paragraph or no mention at all about pregnancy or aspects of fetal/neonatal development.
- Formalized source of maternal/fetal endocrine physiology and pathophysiology
- Key reference for fellows and residents for rarer endocrine pathologies
- Integrated presentation of new molecular and genetic causes of endocrine disorders
- Bridges the experience/knowledge gap of endocrinopathies rarely encountered in pregnancy
Section 1: THE MOTHER A. Normal endocrine physiology of the mother during pregnancy and lactation 1. Hypothalamus 2. The pineal gland and its function in pregnancy and lactation 3. Pituitary 4. Physiology of the Thyroid during Pregnancy, Postpartum and Lactation 5. Physiology of Calcium, Phosphorus, and Bone Metabolism During Pregnancy, Lactation, and Post-Weaning 6. Gestational Glucose Metabolism: Focus on the Role & Mechanisms of Insulin Resistance 7. Intestinal and neuroendocrine hormones 8. Adrenal cortex and medulla physiology during pregnancy, labor and puerperium 9. Ovarian Function During Pregnancy and Lactation 10. The physiological roles of the renin angiotensin aldosterone system and vasopressin in human pregnancy 11. Central role of adipose tissue in pregnancy and lactation 12. Hormonal regulation of the menstrual cycle and ovulation 13. Maintenance of pregnancy and parturition 14. Hormonal regulation of milk production 15. Postpartum Lactational Amenorrhea and Recovery of Reproductive Function and Normal Ovulatory Menstruation
B. Maternal endocrine disorders during pregnancy and lactation 16. Hypothalamic 17. Pineal 18. Pituitary disorders (hyper and hypofunction, tumors) 19. Thyroid (hyperthyroidism, hypothyroidism) 20. Thyroid Cancer during Pregnancy and Lactation 21. Disorders of Mineral and Bone Metabolism During Pregnancy and Lactation 22. Gestational and type 2 diabetes 23. Type 1 Diabetes: During preconception, pregnancy, postpartum, breastfeeding 24. Gut and pancreatic neuroendocrine tumors in pregnancy and lactation 25. Adrenal pathologies during pregnancy and post-partum 26. Hypertension in pregnancy 27. Obesity
C. Other 28. Fertility, pregnancy, and chest feeding in transgendered individuals
Section 2: THE CHILD D. Normal endocrine development and physiology of the fetus and neonate 29. Endocrinology of implantation 30. Hypothalamus and pituitary 31. Pineal 32. Thyroid 33. Physiology of Calcium, Phosphorus, and Bone Metabolism During Fetal and Neonatal Development 34. Developmental Physiology of Carbohydrate Metabolism and the Pancreas 35. Developmental Origins and Roles of Intestinal Enteroendocrine Hormones 36. Adrenal cortex and medulla 37. Ovaries and Testes 38. Renin-angiotensin-aldosterone system and vasopressin 39. Origins of Adipose Tissue and Adipose Regulating Hormones 40. Fetal growth physiology 41. Placental production of steroid and peptide hormones
E. Endocrine disorders affecting the fetus or neonate 42. Hypothalamus and pituitary 43. Pineal 44. Thyroid (agenesis, hypothyroidism, fetal Graves’, etc.) 45. Disorders of Calcium, Phosphorus and Bone Metabolism During Fetal and Neonatal Development 46. Pancreas and carbohydrate metabolism (diabetes and hypoglycemia) 47. Intestinal enteroendocrine disorders 48. Adrenal disorders of the fetus and neonate 49. Disorders of Sex Differentiation 50. Renin-angiotensin-aldosterone and vasopressin 51. Obesity / perinatal origins of obesity 52. Fetal growth failure 53. New Technologies in Pre- and Post-natal Diagnosis
Christopher S. Kovacs, MD,
is a Professor of Medicine (Endocrinology and Metabolism), Obstetrics & Gynecology, and BioMedical Sciences at Memorial University of Newfoundland, Canada. He obtained his MD and trained in Internal Medicine at Queens University, and did his clinical fellowship in Endocrinology and Metabolism at the University of Alberta. Dr. Kovacs did a postdoctoral research fellowship in bone and mineral metabolism at Harvard Medical School and Massachusetts General Hospital. His clinical practice focuses on osteoporosis, disorders of bone metabolism, thyroid disorders, and general endocrinology. His basic, translational, and clinical research focuses on adaptations in calcium and bone metabolism that occur during reproduction and fetal development.
Dr. Kovacs has received over a dozen national and international awards for excellence in research, including the 2003 Gold Medal in Medicine from the Royal College of Physicians and Surgeons of Canada; the 2003 Young Investigator Award from the Canadian Society of Endocrinology and Metabolism, and Young Investigator Awards from the American Society for Bone and Mineral Research and Advances in Mineral Metabolism (AIMM). He is also past President of AIMM.
Cheri L. Deal, PhD, MD,
is a Professor of Endocrinology in the Department of Pediatrics, University of Montreal, and the Chief of the Endocrinology Service at the Ste-Justine Mother-Child University Teaching Hospital in Montreal, Canada. Her training took her to McGill University, University of Montreal, and finally Stanford University for her endocrine research fellowship in placental growth. Past President of both the Canadian Pediatric Endocrine Group and the Canadian Society of Endocrinology and Metabolism, she now chairs the Education Committee of the International Society of Endocrinology. Her awards include the Young Investigator Award from the Pediatric Endocrine Society (previously LWPES), and most recently the Harvey Guyda Educator of the Year Award and the Robert Volpé Service Award from the Canadian Society of Endocrinology and Metabolism.
Her major research interest is in the contribution of the growth hormone-insulin-like growth factor (GH-IGF) axis to the regulation of human growth. She has a strong commitment to patient-driven research, and has helped to elucidate the molecular defects associated with a wide range of rare pediatric endocrine disorders as well as participated in clinical studies aimed at ameliorating outcomes in a variety of pediatric endocrine diseases.
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