Innate Immune System of Skin and Oral Mucosa: Properties and Impact in Pharmaceutics, Cosmetics, and Personal Care Products

An in-depth look at cutting-edge research on the body's innate immune system

Innate immunity is the body's first line of protection against potential microbial, viral, and environmental attacks, and the skin and oral mucosa are two of the most powerful barriers that which we rely on to stay well. The definitive book on the subject, Innate Immune System of Skin and Oral Mucosa: Properties and Impact in Pharmaceutics, Cosmetics, and Personal Care Products provides a comprehensive overview of these systems, including coverage of antimicrobial peptides and lipids and microbial challenges and stressors that can influence innate immunity.

Designed to help experts and newcomers alike in fields like dermatology, oral pathology, cosmetics, personal care, and pharmaceuticals, the book is filled with suggestions to assist research and development. Looking at the many challenges facing the innate immune system, including the impact of topically applied skin products and medications, Innate Immune System of Skin and Oral Mucosa paves the way for next generation treatment avenues, preventative approaches, and drug development.

Preface.

Contributors.

I. Overview of skin and mucosa innate immunity: history, ethics and science.

1.Historical overview of the use of soaps and cleaning products (Jennifer Tebbe-Grossman and Martha N. Gardner).

2. Ethical responsibilities in formulating, marketing and using antimicrobial products (Kenneth Richman).

3. Stratum corneum structural and functional contributions to cutaneous antimicrobial defense (Peter Elias).

II. Antimicrobial lipids and peptides.

4. Antimicrobial Lipids of the Skin and Oral Mucosa (K. A. Brogden, D. R. Drake, D. V. Dawson, J. R. Hill, C. Bratt, P. W. Wertz).

5. Resident microflora and antimicrobial peptides of skin (Shamim Ansari).

6. Diffensins (Neelam Muizzudin).

7. Antimicrobial peptides of skin and oral mucosa (Whasun Oh Chung and Henrik Dommisch).

8. Vernix Caseosa and Innate Immunity (Steven B. Hoath, MD, Vivek Narendran, MD, Marty O. Visscher, PhD).

III. Host cellular components of innate immunity.

9. Sentinel role of mast cells in innate immunity (Zhenping Wang, Anna Di Nardo).

10. Cellular immunity of the skin: Langerhans cells and dendritic cells (Karen E. Burke and Niroshana Anandasabapathy).

IV. Innate immunity response to stress and aging.

11. Changes in skin immunity with age and disease (Barbara Geusens, Ilse Mollet, Chris D. Anderson, Sarah Terras, Michael S. Roberts and Jo Lambert).

12. Epidermis as a shield from radiation and oxidative stress (Giuseppe Valacchi).

13. The impact to skin’s innate immunity by cosmetic products applied to skin and scalp (Rudranath Persau and Thomas Re).

14. UV induced immunosuppression of skin (Roger L. McMullen).

V. Innate immunity microbial challenges.

15. Deranged Anti-microbial Barrier in Atopic Dermatitis: Roles of Sphingosine, Hexadecenoic Acid and Beta-Defensine-2 (Gengi Imokawa).

16. Resident microflora of skin and oral mucosa (David Drake).

17. Corynebacterium species and their role in the generation of human malodor (Carol Bratt and Nava Dayan).

Index.

Nava Dayan PhD, is the R&D Director at Lipo Chemicals Inc. and an Associate Adjunct Professor in the Ernest Mario School of Pharmacy at Rutgers University. During her twenty four years of experience she has specialized in a variety of areas related to skin treatment, especially in the research and understanding of the interaction between topically applied compounds and the skin. Dr. Dayan has received numerous awards for excellence for various papers she has authored. She is the author and coauthor of more than a hundred and fifty publications, including book chapters, and has been granted eight patents. She is also the editor of three books, including Formulating, Packaging, and Marketing of Natural Cosmetic Products (Wiley).

Philip W. Wertz PhD, is a Professor in the Department of Oral Pathology, Radiology, and Medicine at the University of Iowa College of Dentistry and in The Dows Institute for Dental Research. He is currently on the Editorial Advisory Board of the International Journal of Cosmetic Science and the Editorial Board of the TransDermal and Journal of Lipids.

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