Hematopathology (A Volume in the High Yield Pathology Series)

By Jon C. Aster, MD, PhD, Professor, Department of Pathology, Harvard Medical School; Brigham and Women's Hospital, Boston, MA; Olga Pozdnyakova, MD, PhD, Instructor, Department of Pathology, Harvard Medical School; Associate Pathologist, Department of Pathology, Brigham and Women’s Hospital, Boston, MA and Jeffery L. Kutok, MD, PhD, Senior Director, Biology and Translational Research, Infinity Pharmaceuticals, Inc., Cambridge, MA Description: Recognize the classic look of hematologic diseases and quickly confirm your diagnoses with Hematopathology: A Volume in the High Yield Pathology Series. A templated format, excellent color photographs, authoritative content, and online access make this an ideal reference for busy pathologists. New To This Edition: Find information quickly and easily with a templated, easy-to-reference format and concise, bulleted text. Confirm your diagnoses with excellent color photographs that demonstrate the classic appearance of the full range of hematologic diseases - both benign and malignant - including immunodeficiency-associated lymphoproliferative disorders, such as AIDS; disorders of coagulation; bone marrow failure syndromes; and all of the different types of leukemia and lymphoma. Depend on authoritative information from leading pathologists. Access the full text online, perform quick searches, and download images at Expert Consult. Table Of Contents: I. INHERITED RED CELL DISORDERS A. Thalassemias Alpha-Thalassemia Beta-Thalassemia B. Hemoglobinopathies Sickle Cell Disease Hemoglobin C Disease Hemoglobin E Disease Heinz Body Hemolytic Anemia C. Enzyme Defects Glucose-6-Phosphate Dehydrogenase (G6PD) Deficiency Pyruvate Kinase Deficiency D. Disorders of Heme Synthesis Sideroblastic Anemia (Congenital and Acquired) E. Red Cell Membrane Disorders Hereditary Spherocytosis Hereditary Elliptocytosis (HE) and Related Disorders F. Other Congenital Red Cell Disorders Congenital Dyserythropoietic Anemia (CDA) II. ACQUIRED RED CELL DISORDERS A. Red Cell Membrane Disorders Paroxysmal Nocturnal Hemoglobinuria (PNH) B. Nutritional Deficiencies Iron Deficiency Anemia (IDA) Folate and B12 (Cobalamin) Deficiency C. Toxins Lead Toxicity Hematologic Complications of Alcoholism D. Intravascular Hemolysis Traumatic Hemolysis E. Immunologic Destruction Autoimmune Hemolytic Anemia (AIHA) F. Myelophthisic Anemias Metastatic Lesions in Bone Marrow Biopsies Gaucher Disease Storage Disorders: Niemann-Pick Disease (NPD) G. Red Cell Aplasias Red Cell Aplasia Parvovirus Infection III. INHERITED WHITE CELL AND PLATELET DISORDERS Chediak-Higashi Syndrome Gray Platelet Syndrome May-Hegglin Anomaly Pelger-Huet Anomaly IV. INFECTIOUS DISORDERS SEEN IN BLOOD Malaria Babesiosis Ehrlichiosis/Anaplasmosis African Trypanosomiasis Chagas Disease V. DISORDERS OF HEMOSTASIS Disseminated Intravascular Coagulation (DIC) Thrombotic Thrombocytopenia Purpura (TTP)/Hemolytic Uremic Syndrome (HUS) VI. BONE MARROW FAILURE SYNDROMES Aplastic Anemia VII. REACTIVE LYMPHADENOPATHIES A. Infections Tuberculosis and Mycobacterial Lymphadenopathy Cryptococcus Lymphadenitis Histoplasmosis Candidiasis Infectious Mononucleosis Cytomegalovirus (CMV) Infection Herpes Simplex Virus (HSV) Lymphadenitis Toxoplasmosis Syphilitic Lymphadenitis B. Non-Infectious Sarcoidosis Systemic Lupus Erythematosus (SLE) Lymphadenopathy Rheumatoid Lymphadenopathy Castleman Disease a. Hyaline Vascular Variant b. Multicentric/Plasma Cell Variant Foreign Body Lymphadenopathy Dermatopathic Lymphadenopathy Non-Specific Lymphadenopathy VIII. REACTIVE HISTIOCYTIC DISORDERS Rosai-Dorfman Disease Erdheim-Chester Disease Hemophagocytic Lymphohistiocytosis (Primary and Acquired) IX. LYMPHOID NEOPLASMS A. Lymphoblastic Neoplasms B Lymphoblastic Leukemia/Lymphoma (B-ALL/LBL) T Lymphoblastic Leukemia/Lymphoma (T-ALL/LBL) B. Mature B-Cell Neoplasms Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma B-Cell Prolymphocytic Leukemia Hairy Cell Leukemia Hairy Cell Leukemia---Variant Splenic Marginal Zone Lymphoma Extranodal Marginal Zone Lymphoma A. Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue (MALT Lymphoma) B. Cutaneous Marginal Zone Lymphoma Nodal Marginal Zone Lymphoma Lymphoplasmacytic Lymphoma Mantle Cell Lymphoma Follicular Lymphoma Primary Cutaneous Follicle Center Lymphoma Burkitt Lymphoma (BL) Diffuse Large B-Cell Lymphoma (DLBCL), Not Otherwise Specified (Including with Chronic Inflammation) B-Cell Lymphoma, Unclassifiable, With Features Intermediate between Diffuse Large B-Cell Lymphoma (DLBCL) and Burkitt Lymphoma T-Cell/Histiocytic-Rich Large B-Cell Lymphoma B-Cell Lymphoma, Unclassifiable, with Features Intermediate between Diffuse Large B-Cell Lymphoma and Classical Hodgkin Lymphoma (CHL) Primary Diffuse Large B-Cell Lymphoma (DLBCL) of the CNS Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type EBV-Positive Diffuse Laarge B-Cell Lymphoma (DLBCL) in the Elderly Lymphomatoid Granulomatosis Primary Mediastinal Large B-Cell Lymphoma (PMBCL) Intravascular Lymphoma Plasmablastic Lymphoma Large B-Cell Lymphoma Arising in HHV-8-Associated Multicentric Castleman Disease (MCD) Primary Effusion Lymphoma and Related Entities ALK+ Large B-Cell Lymphoma C. Plasma Cell Neoplasms Monoclonal Gammopathy of Undetermined Significance Plasma Cell Myeloma Plasmacytoma Immunoglobulin Deposition Diseases Osteosclerotic Myeloma D. Mature T-Cell and NK-Cell Neoplasms Mycosis Fungoides Sézary Syndrome Primary Cutaneous CD30+ T-Cell Lymphoproliferative Disorders Lymphomatoid Papulosis (LYP) Primary Cutaneous Anaplastic Large Cell Lymphoma (ALCL) Primary Cutaneous Gamma-Delta T-Cell Lymphoma Primary Cutaneous CD8+ Aggressive Epidermotropic Cytotoxic T-Cell Lymphoma Primary Cutaneous CD4+ Small/Medium T-Cell Lymphoma T-Cell Prolymphocytic Leukemia T-Cell Large Granular Lymphocytic Leukemia (T-LGL) Peripheral T-Cell Lymphoma, Not Otherwise Specified Angioimmunoblastic T-Cell Lymphoma Anaplastic Large Cell Lymphoma, ALK+ Anaplastic Large Cell Lymphoma, ALK- EBV-Positive T-Cell Lymphoproliferative Disorders of Childhood Systemic EBV-Positive T-Cell Lymphoproliferative Disease of Childhood Hydroa Vacciniforme-Like Lymphoma Adult T-Cell Leukemia/Lymphoma (ATLL) Enteropathy-Associated T-Cell Lymphoma (EATL) Hepatosplenic T-Cell Lymphoma Subcutaneous Panniculitis-Like T-Cell Lymphoma E. NK-Cell Neoplasms Extranodal NK/T-Cell Lymphoma Aggressive NK-Cell Leukemia Chronic Lymphoproliferative Disorder of NK Cells F. Classical Hodgkin Lymphoma Nodular Sclerosis Type Mixed Cellularity Type Lymphocyte-Rich Type Lymphocyte-Depleted Type Nodular Lymphocyte-Predominant Hodgkin Lymphoma X. IMMUNODEFICIENCY-ASSOCIATED LYMPHOPROLIFERATIVE DISORDERS A. HIV-Associated Lymphoproliferative Disorders HIV Lymphadenitis HIV-Associated Lymphoproliferative Disorders B. Post-Transplant Lymphoproliferative Disorders (PTLDs) Early, Polymorphic, Monomorphic, and Hodgkin Types C. Primary Immunodeficiency-Associated Lymphoproliferative Disorders Overview of Primary Immunodeficiency-Associated Lymphoproliferative Disorders Autoimmune Lymphoproliferative Syndrome (ALPS) XI. MYELOID NEOPLASMS A. Myeloproliferative Disorders Chronic Myelogenous Leukemia (CML) Chronic Neutrophilic Leukemia (CNL) Polycythemia Vera (PV) Essential Thrombocythemia (ET) Primary Myelofibrosis (PMF) Chronic Eosinophilic Leukemia (CEL) Mastocytosis B. Myeloid and Lymphoid Neoplasms with Eosinophilia and Abnormalities of PDGFRA, PDGFRB, or FGFR1 C. Myelodysplastic/Myeloproliferative Neoplasms Chronic Myelomonocytic Leukemia Atypical Chronic Myeloid Leukemia Juvenile Myelomonocytic Leukemia (JMML) D. Myelodysplastic Syndromes Refractory Anemia with Unilineage Dysplasia Refractory Anemia with Ring Sideroblasts Refractory Cytopenia with Multilineage Dysplasia Refractory Anemia with Excess Blasts (RAEB) Myelodysplastic Syndrome (MDS) with Isolated del(5q) E. Acute Myeloid Leukemia with Recurrent Genetic Aberrations AML with t(8;21)(q22;q22); RUNX1/RUNX1T1 Acute Myeloid Leukemia (AML) with inv (16)(p13. 1q22) or t(16;16)(p13. 1;q22); CBFB-MYH11 Acute Promyelocytic Leukemia with t(15;17)(q22;q12); PML-RARA Acute Myeloid Leukemia (AML) with t(9;11)(p22;q23); MLLT3-MLL Acute Myeloid Leukemia (AML) with t(6;9)(p23;q34); DEK-NUP214 Acute Myeloid Leukemia with (AML) inv(3)(q21q26. 6) or t(3;3)(q21;q26. 2);RPN1-EVI1 Acute Myeloid Leukemia (AML) (Megakaryoblastic) with t(1;22)(p13;q13); RBM15-MKL1 Acute Myeloid Leukemia (AML) with Mutated NPM1 Acute Myeloid Leukemia (AML) with Mutated CEBPA F. Acute Myeloid Leukemia, Not Otherwise Specified AML with Minimal Differentiation Acute Myeloid Leukemia (AML) without Maturation Acute Myeloid Leukemia (AML) with Maturation Acute Myelomonocytic Leukemia Acute Monoblastic Leukemia Acute Monocytic Leukemia Acute Erythroid Leukemia, Erythroid/Myeloid Subtype Acute Erythroid Leukemia, Pure Erythroid Leukemia Subtype Acute Megakaryoblastic Leukemia G. Acute Myeloid Leukemia (AML) with Myelodysplasia-Related Changes H. Therapy-Related Myeloid Neoplasms I. Myeloid Sarcoma J. Myeloid Proliferations Related to Down Syndrome (DS) K. Blastic Plasmacytoid Dendritic Cell Neoplasm XII. HISTIOCYTIC AND DENDRITIC CELL NEOPLASMS Histiocytic Sarcoma Langerhans Cell Histiocytosis Langerhans Cell Sarcoma Follicular Dendritic Cell Sarcoma Interdigitating Dendritic Cell Sarcoma Indeterminate Dendritic Cell Tumor Fibroblastic Reticular Cell Tumor XIII. THYMOMA AND THYMIC CARCINOMA Thymoma Thymic Carcinoma Prin Jon C. Aster, MD, PhD, Profesor, Departamentul de Patologie, Harvard Medical School; Brigham si Womens Hospital, Boston, MA; Olga Pozdnyakova, MD, PhD, instructor, Departamentul de Patologie, Harvard Medical School; Patolog asociat, Departamentul de Patologie, Brigham si Womens Hospital, Boston, MA și Jeffery L. Kutok, MD, PhD, Senior Director, Biologie și rezultatelor cercetarii, Infinity Pharmaceuticals, Inc, Cambridge, MA Descriere: Recunoaste aspectul clasic de boli hematologice și rapid confirma diagnostice tale cu Hematopathology: Un volum în mare capacitate de Patologie Series. Un format modelată, fotografii excelente de culoare, conținut autoritar, și acces on-line a face acest lucru o referință ideală pentru patologi ocupat. Nou în acest Edition: Găsiți informații rapid și ușor cu un, format modelată ușor de referință și de text concis, marcatori. Confirmați diagnostice dvs. cu fotografii excelente color care demonstrează aspectul clasic de întreaga gamă de boli hematologice - benigne și maligne - inclusiv afecțiuni limfoproliferative asociate-imunodeficitare, cum ar fi SIDA; tulburari de coagulare; osoase sindroamele esec maduvei; și toate din diferite tipuri de leucemie și limfom. Depinde de informații oficiale de la patologi de conducere. Acces la textul integral on-line, efectua căutări rapide, și de a descărca imagini de la Expert Consult. Cuprins: I. moștenit tulburări ale celulelor RED A. talasemia Alpha-talasemie Beta-talasemie B. hemoglobinopathies Siclemie Hemoglobina Boala C Hemoglobina Bolilor E Heinz corp Anemia hemolitica Defecte C. enzime Glucoză-6-fosfat dehidrogenază (G6PD) Deficienta Piruvat kinazei Deficienta D. Tulburari de Hem Sinteza Anemia sideroblastică (congenitală sau dobândită) E. Red afecțiunilor membranei celulare spherocytosis ereditar Ereditar Elliptocytosis (HE) si tulburari F. Alte congenitale Red Cell Tulburari Congenitale Dyserythropoietic Anemia (CDA) II. DOBÂNDITE tulburări ale celulelor RED A. Red afecțiunilor membranei celulare Paroxistica Nocturnal Hemoglobinuria (PNH) B. Nutritional Deficiențe Anemie deficit de fier (IDA) Acidul folic și vitamina B12 (cobalamina) Deficienta C. Toxinele Toxicitatea plumb Complicatiile hematologice de alcoolism D. intravascular cu hemoliza Hemoliza post-traumatic E. imunologic Distrugerea Anemia hemolitica autoimuna (AIHA) F. Myelophthisic Anemiile Leziuni metastatice din maduva osoasa Biopsiile Boala Gaucher Tulburari de depozitare: Niemann-Pick boala (NPD) G. Celula Roșie Aplasias Aplazia Red Parvovirus Infecție III. De celule si trombocite TULBURĂRI WHITE moștenit Chediak-Higashi Sindromul Gray Sindromul de trombocite Mai-HEGGLIN Anomaly Pelger-Huet anomalie IV. Tulburări infecțioase văzut în SÂNGE malaria babesioza Ehrlichiosis / Anaplasmoza african Trypanosomiasis Boala Chagas V. tulburări ale hemostazei Coagulare intravasculara diseminata (DIC) Trombotică trombocitopenie Purpura (PTT) / sindrom hemolitic uremic (SHU) VI. Maduva osoasa de insuficiență anemie aplastică VII. limfadenopatie REACTIVI A. Infecții Tuberculoza și mycobacteriene limfadenopatie Cryptococcus Limfadenita histoplasmoza candidoza mononucleoza infecțioasă Citomegalovirusul (CMV) de infectare Virus Herpes Simplex (HSV) Limfadenita toxoplasmoza sifilitic Limfadenita B. non-infecțioase sarcoidoza Lupus eritematos sistemic (LES) limfadenopatie reumatoidă Limfadenopatia Boala Castleman o. Hialin Varianta vasculare b. Multicentric / cu plasmă Cell Variant Corpul de Externe Limfadenopatia Dermatopathic Limfadenopatia Nespecifice limfadenopatie VIII. TULBURĂRI histiocitara REACTIVI Rosai-Dorfman Bolilor Erdheim-Chester Bolilor Hemofagocitic lymphohistiocytosis (primară sau dobândită) IX. limfoide Tumori A. limfoblastică Tumori B limfoblastice leucemie / limfom (B-ALL / LBL) T limfoblastice leucemie / limfom (T-ALL / LBL) Tumori B. Mature B-Cell Leucemie limfocitara cronica / mici limfocitara Limfomul B-Cell Prolymphocytic leucemie Hairy leucemie cu celule Leucemia Hairy Cell --- Variant Splenică marginală Zone Limfomul Extranodale marginal Zone Limfomul A. extranodale marginală Zona Limfomul a mucoasei-asociate țesut limfoid (limfom MALT) B. cutanata marginal Limfomul Zone Nodal marginal Zone Limfomul limfoplasmocitar Limfomul Mantle celule de limfom limfom folicular Primar cutanat folicul Centrul de limfom Limfom Burkitt (BL) Difuz cu celule B mari Limfom (DLBCL), nu se specifică altfel (inclusiv cu inflamatia cronica) B-Cell limfom, neclasificabile, cu caracteristici intermediare între difuze cu celule B mari Limfom (DLBCL) și limfom Burkitt T-Cell / histiocitara-Rich mare Limfomul cu celule B B-Cell limfom, neclasificabile, cu caracteristici intermediar între difuz cu celule B mari și clasică Hodgkin (CHL) Primar difuze Large B-Cell Limfomul (DLBCL) din SNC Primar cutanat difuze cu celule B mari de tip Limfom, Leg EBV-pozitiv difuz Laarge B-Cell Limfomul (DLBCL), la varstnici limfomatoida granulomatoza Primar mediastinal cu celule B mari Limfom (PMBCL) Limfomul intravascular Plasmablastic Limfomul Cu celule B mari Limfom care apar în HHV-8-asociate multicentric Boala Castleman (MCD) Primar efuziune Limfomul și entitățile afiliate ALK + mare Limfomul cu celule B C. Plasma Tumori celulare Monoclonal gamapatie de semnificatie nedeterminata Plasma celulă de mielom plasmocitom Imunoglobulina depunere Boli osteosclerotic mielom D. Mature T-Cell și Tumori NK-Cell fungoides Sindromul Sézary Tulburări limfoproliferative primar cutanat CD30 + celule T- Limfomatoida papulosis (LYP) Primar cutanat anaplastic cu celule mari Limfomul (ALCL) Primar cutanat Gamma-Delta T-Cell Limfomul Primar cutanat CD8 + agresiv epidermotrop T citotoxice-Cell Limfomul Primar cutanat CD4 + mic ​​/ mediu T-Cell Limfomul T-Cell Prolymphocytic leucemie T-celule mari granulat leucemie limfocitară (T-LGL) Periferice T-Cell Limfomul nespecificate în altă parte Angioimmunoblastic limfom cu celule T Anaplazic cu celule mari Limfom, ALK + Anaplazic cu celule mari Limfom, ALK- EBV-pozitiv T-Cell limfoproliferative afecțiuni ale copilăriei Sistemic EBV-pozitiv T-Cell Boala limfoproliferativă de copilarie Hydroa Vacciniforme-Ca limfom Adult T-Cell leucemie / limfom (ATLL) Enteropatie-Asociat T-Cell Limfomul (EATL) Hepatosplenic T-Cell Limfomul Subcutanată Panniculitis-Ca T-Cell Limfomul Tumori E. NK-Cell Extranodale NK / T-Cell Limfomul Agresiv leucemie NK-Cell Tulburare limfoproliferativă cronică de celule NK F. clasică Hodgkin Nodular Scleroza Tip Mixed Tip celularitate Tip de limfocite-Rich Sărăcit-limfocitelor de tip Nodular limfocitelor-predominantă Hodgkin X. asociate cu imunodeficienta tulburări limfoproliferative Tulburari A. HIV-asociate limfoproliferative HIV Limfadenita Tulburari HIV-asociate limfoproliferative B. post-transplant tulburări limfoproliferative (PTLDs) Primele, tipuri polimorfă, monomorfe, și Hodgkin Tulburari C. primar imunodeficientei-Asociat limfoproliferative Privire de ansamblu de tulburari primare imunodeficientei-Asociat limfoproliferative Sindromul limfoproliferativă autoimune (ALPS) XI. Tumori mieloide Tulburări A. mieloproliferative Leucemia mieloidă cronică (LMC) Cronica neutrofilică Leucemie (CNL) Policitemia vera (PV) Trombocitemia esențială (ET) Mielofibroza primara (PMF) Cronica eozinofilica acuta (CEL) mastocitoza B. mieloidă și limfoidă Tumori cu eozinofilie și Anomalii de PDGFRA, PDGFRB, sau FGFR1 C. mielodisplazice / mieloproliferative Tumori Leucemia mielomonocitară cronică Atipic leucemiei mieloide cronice Mielomonocitară juvenilă Leucemie (JMML) D. sindroame mielodisplazice Anemia refractară cu displazie Unilineage Anemia refractară cu inel inelari Citopenie refractara cu multilineage Displazia Anemia refractară cu exces de blaști (AREB) Sindromul mielodisplazic (MDS), cu izolat del (5q) E. Leucemia mieloida acuta cu recurente genetice Aberațiile AML cu t (8; 21) (q22; Q22); RUNX1 / RUNX1T1 Leucemia mieloida acuta (LMA), cu inv (16) (p13. 1q22) sau t (16; 16) (P13. 1, Q22); CBFB-MYH11 Acuta Leucemia promielocitara cu t (15; 17) (q22; Q12); PML-Rara Leucemia mieloida acuta (LMA), cu t (9; 11) (P22, Q23); MLLT3-MLL Leucemia mieloida acuta (LMA), cu t (6, 9) (P23, Q34); DEK-NUP214 Leucemia mieloida acuta cu (AML) inv (3) (q21q26. 6) sau t (3, 3) (Q21; Q26. 2); RPN1-EVI1 Leucemia mieloida acuta (AML) (megakaryoblastic) cu t (1, 22) (P13, Q13); RBM15-MKL1 Leucemia mieloida acuta (LMA), cu mutant NPM1 Leucemia mieloida acuta (LMA), cu mutant CEBPA F. Leucemia mieloida acuta nespecificate în altă parte AML cu minim Diferențierea Leucemia mieloida acuta (AML) fără maturare Leucemia mieloida acuta (LMA), cu maturare Acută mielomonocitică Leucemia Acută Monoblastic Leucemia Acută monocitică Leucemia Acută eritroide leucemie, eritroide / Subtip mieloide Acută eritroide leucemie, Pure eritroide leucemie Subtip Acută megakaryoblastic Leucemia G. Leucemia mieloida acuta (LMA), cu Mielodisplazia-Modificări corelate Mieloide H. Terapia legate de Tumori I. mieloida Sarcom J. mieloide proliferări legate de sindromul Down (DS) K. blastică plasmacytoid dendritice Tumoră Cell XII. Histiocitara ȘI dendritice Tumori CELULARE histiocitara Sarcom Langerhans histiocitoza Cell Langerhans Sarcom Cell Folicular Sarcom Cell dendritice Interdigitating dendritice Sarcom Cell Nedeterminate celulara a tumorii dendritice Fibroblastic celulara a tumorii reticular XIII. Timom ȘI timusului CANCERUL timom timusului Carcinomul