Fundamentals of HIV Medicine 2023

The essential textbook for HIV care providers and pharmacists—updated for 2023!

Fundamentals of HIV Medicine has served as a key resource for clinicians preventing and treating HIV for over a decade. An end-to-end clinical resource for the treatment of individuals with HIV/AIDS, Fundamentals of HIV Medicine 2023 offers practitioners immediate, indexed access to the most recent science, research, and guidelines related to all aspects of HIV care and prevention.

Now updated to reflect the convergent knowledge at the intersection of two global pandemics, HIV and COVID-19, Fundamentals of HIV Medicine 2023 offers state-of-the-art continuing education for physicians, pharmacists, nurse practitioners, PAs, nurses, and other professionals working in the care of people with HIV. This revised edition features key clinical updates across classic domains of HIV medicine along with new understandings of injectable antiretroviral treatment and explorations into concepts of HIV latency for long-term viral remission.

Embodying the American Academy of HIV Medicine's commitment to excellence in the care of seropositive patients, Fundamentals of HIV Medicine 2023 is a must-have for health professionals across HIV care, treatment, and prevention.

• The authoritative and state-of-the-art reference work on the clinical care of HIV/AIDS, authored by more than 50 expert clinicians in immunology, HIV epidemiology, gerontology, substance abuse treatment, infectious disease, and related fields central to its medical management
• Topic-based chapters on all aspects of clinical care and proficiency, including: epidemiology and prevention; basic science; clinical management; social, economic, and population factors; and clinical research
• Extensive information on the treatment challenges and recommendations for managing co-infection and comorbidities
• Appropriate for physicians and a wide range of non-physician health professionals, including dentists, nurses, pharmacists, and workers outside clinical settings

New to this Edition:

• Evolving research and recommendations for HIV care during the COVID-19 pandemic
• Updated clinical insights behind injectable antiretroviral treatment and PrEP
• The newest findings on HIV latency and long-term viral remission

Target Audience
Overall Learning Objectives
Faculty
Disclosure of Conflicts of Interest
Disclosure of Unlabeled Use
Preface
W. David Hardy
1. Ending the HIV Epidemic
Benjamin Sokoloff
2. Epidemiology and the Spread of HIV
Laurel Banach, Meagan Goodier, and Philip Bolduc
3. Origin, Evolution, and Spread of HIV1 & HIV2
Jeffrey T. Kirchner
4. Mechanisms of HIV Transmission
Nancy Aitcheson and Puja H. Nambiar
5. Transmission Prevention Strategies
Carolyn Chu, Katrina Baumgartner, and Christopher M. Bositis
6. Immunology
Dennis J. Hartigan-O'Connor and Christian Brander
7. HIV Testing and Counseling
Alejandro Delgado
8. Laboratory Testing Strategies, Detection, and Diagnosis
Kruti J. Yagnik and Jessica A. Meisner
9. Initial Evaluation of the Person with HIV: History, Physical Evaluation, and Laboratory Evaluation
Esteban DelPilar Morales and Daniel J. Skiest
10. Health Maintenance
Ramiz Kseri
11. Diversity Awareness
Gary F. Spinner
12. Special Populations
12. 1 Adolescent HIV Care
Catherine Silva and Renata Arrington-Sanders
12. 2 HIV and Transgender Populations
Zil G. Goldstein and Madeline B. Deutsch
12. 3 Care of PWH Who Experience Homelessness or Unstable Housing
Elizabeth Imbert and Matthew D. Hickey
12. 4 HIV in Criminal-Legal Involved People
Olabimpe Asupoto and Alysse Wurcel
12. 5 Rural Populations and HIV
Abby Davids and Ashley Carvalho
12. 6 Care of Migrant and Immigrant Persons with HIV
Deliana Garcia, Claire Hutkins Seda, and Laszlo Madaras
13. Complementary and Alternative Medicine/Integrative Medicine Approaches
Yash Desai and Kalpana D. Shere-Wolfe
14. HIV Care Coordination
Margret O. Nelson
15. The Pharmacist's Role in HIV Care
Jennifer Cocohoba
16. Virology and Natural History of HIV
Poonam Mathur
17. Scientific Basis of Antiretroviral Therapy
David E. Koren, Neha Sheth Pandit, and Emily Heil
18. Prescribing Antiretroviral Therapy
Poonam Mathur, Steven Mudroch, Saira Ajmal, Zelalem Temesgen, and David E. Koren
19. The HIV Reservoir and Cure and Remission Strategies
Boris Juelg, Rajesh Gandhi, and Nikolaus Jilg
20. HIV Drug Resistance: Evaluation and Clinical Management
Carolyn Chu, Lealah Pollock, and Robert Shafer
21. Antiretroviral Treatment and Stewardship in Hospital Settings
David E. Koren
22. Solid Organ Transplantation in Persons with HIV
Christine M. Durand
23. Select Topics in the Care of Cis-Gender Women with HIV
Jillian T. Baron, Christina E. Maguire, and William R. Short
24. Antiretroviral Therapy for Children and Newborns
Karin Nielsen-Saines
25. Understanding and Managing Antineoplastic and Antiretroviral Therapy
Elizabeth M. Sherman and Taylor K. Gill
26. Substance Use in HIV Populations
Thanh Thuy Truong and Elizabeth David
27. Caring for Older People with HIV
Aroonsiri Sangarlangkarn, John D. Zeuli, and Anchalee Avihingsanon
28. Opportunistic Infections
Lisa Armitige, Karen J. Vigil, and Rita Wilson Dib
29. Malignancies in HIV
Eva H. Clark and Elizabeth Y. Chiao
30. Dermatologic Complications of HIV
Kudakwashe Mutyambizi, Craig Weeks, and Philip Bolduc
31. Endocrine and Metabolic Disorders
Rajagopal V. Sekhar
32. HIV-Associated Lipodystrophy and Lipoatophy
Rajagopal V. Sekhar
33. Non-Opportunistic Infections: Respiratory Complications
Priyanka Chakrabarti
34. Psychiatric Illness and Treatment in HIV Populations
Richa Vijayvargiya and Elizabeth David
35. Neurologic Effects on HIV Infection
Rodrigo Hasbun and Joseph S. Kass
36. HIV and Hepatitis Coinfection
Karen J. Vigil
37. The COVID-19 Pandemic and HIV
Richard C. Prokesch
38. Sexually Transmitted Diseases
Karen J. Vigil
39. Cardiovascular Disease
Jarrett K. Sell and Jonathan J. Nunez
40. Renal Complications
Patricia Carr Reese and Umar Farooq
41. HIV and Bone Health
Roger Bedimo
42. Immune Reconstitution Inflammatory Syndrome (ISIS)
Dagan Coppock
43. HIV Healthcare Programs and Insurance Coverage in the U. S. Health Care System
Leslie McGorman and Bruce J. Packett, II
44. Legal Issues
Jarrett K. Sell
Index

Editor in Chief: W. David Hardy, Executive Committee Member, American Academy of HIV Medicine, and Compiled by The American Academy of HIV Medicine

About the Editor in Chief: W. David Hardy, MD, is a scientific and medical consultant focusing on developing novel vaccine and cure/remission strategies for human viral diseases. Currently, he serves as Treasurer on the Board of Directors and member of the Executive Committee of the AAHIVM. He has served as Editor in Chief of AAHIVM's comprehensive clinical textbook, Fundamentals of HIV Medicine, since 2007. Dr. Hardy has cared for persons with HIV infection since 1982 and conducted research on HIV and related diseases since 1984. His research focuses on treatment and prevention of opportunistic infections, antiretroviral therapy, immunotherapies, and hepatitis treatments as well as retroviral vector research and cellular and gene therapy for the cure of HIV treatment. Dr. Hardy served as Chair of the Board of Directors of the HIV Medicine Association (HIVMA) and volunteered with several community-based organizations, including AIDS Research Alliance and Project Angel Food.

About the American Academy of HIV Medicine (AAHIVM): The American Academy of HIV Medicine is the nation's leading independent organization of health care professionals dedicated to providing excellence in HIV care and prevention. The Academy's membership of practitioners and credentialed clinicians manage the health of the majority of people with and at risk of HIV in the United States.

Contributors:

Co-Editors

Jonathan S. Appelbaum, MD, FACP, AAHIVS
Roberto C. Arduino, MD
Philip Bolduc, MD
Carolyn Chu, MD, MSc
Jeffrey T. Kirchner, DO, FAAFP, AAHIVS
William R. Short, MD, MPH, FIDSA


Contributors

Nancy Aitcheson
Saira Ajmal, MD
Lisa Y. Armitige, MD, PhD
Renata Arrington-Sanders, MD, MPH, ScM
Anchalee Avihingsanon, MD, PhD
Laural Banach
Jillian T. Baron
Katrina Baumgartner, MD
Roger Bedimo
Christopher M. Bositis, MD
Christian Brander, PhD
Ashley Carvalho
Priyanka Chakrabarti, DO
Elizabeth Chiao, MD, MPH
Eva H. Clark, MD, PhD
Jennifer Cocohoba, PharmD, BCPS, AAHIVP
Dagan Coppock, MD
Elizabeth H. David, MD
Abby Davids, MD, MPH, AAHIVS
Alejandro Delgado, MD
Yash Desai
Esteban A. DelPilar-Morales, MD
Madeline B. Deutsch, MD, MPH
Rita Wilson Dib
Christine M. Durand, MD
Umar Farooq
Rajesh T. Gandhi, MD
Deliana Garcia, MA
Taylor K. Gill, PharmD, BCPS, AAHIVP
Zil Garner Goldstein, FNP-BC
Meagan Goodier
Dennis Joseph Hartigan-O'Connor, MD, PhD
Rodrigo Hasbun, MD, MPH
Emily Heil, PharmD, MS
Matthew D. Hickey
Aroonsiri (Sangarlangkarn) Howell, MD MPH
Elizabeth Imbert
Nikolaus Jilg, MD, PhD
Boris Juelg, MD, PhD
Joseph S. Kass, MD, JD
David E. Koren, PharmD, BCPS, AAHIVP
Ramiz Kseri, MD
Laszlo Madaras, MD, MPH
Christina E. Maguire
Poonam Mathur, DO, MPH
Leslie McGorman
Jessica A. Meisner, MD, MS, MSHP
Steven Mudroch
Kudakwashe Mutyambizi, MD
Puja H. Nambiar, MD
Margret O. Nelson
Karin Nielsen-Saines, MD, MPH
Jonathan J. Nunez
Bruce J. Packett II
Neha Sheth Pandit, PharmD
Lealah Pollock, MD, MS
Richard C. Prokesch, MD
Patricia Carr Reese
Claire M. H. Seda, BA
Rajagopal V. Sekhar, MD
Jarrett K. Sell
Robert Shafer, MD
Kalpana D. Shere-Wolfe, MD
Elizabeth M. Sherman, PharmD
Catherine Silva
Daniel J. Skiest, MD
Ben Sokoloff, DO
Gary F. Spinner, PA, MPH, AAHIVS
Zelalem Temesgen, MD, FIDSA
Tri Minh Trang, MD
Thanh Thuy Truong, MD
Karen Vigil, MD
Richa Vijayvargiya
Craig Steven Weeks, MD
Alysse Wurcel
Kruti J. Yagnik
John D. Zeuli, PharmD

RECENZII