ESC Textbook of Thrombosis (European Society of Cardiology Series)

The ESC Textbook of Thrombosis is the third iteration of Therapeutic Advances in Thrombosis. Now a new addition to the European Society of Cardiology (ESC) publications portfolio, it is informed by the work of the ESC's Working Group on Thrombosis.
Written by internationally renowned experts in the field of thrombosis, the textbook presents an up-to-date and in-depth review of all aspects of thrombosis and antithrombotic therapies. Not only does it reflect contemporary European guidelines from the ESC but also it also summarizes the latest evidence from clinical trials.
Covering the topic in great detail with thirty-one chapters, the textbook is split into four sections: Pathophysiology of thrombosis, Clinical pharmacology of antithrombotic drugs, Therapeutic strategies, and Special situations.
Appealing to the large community of cardiovascular healthcare specialists in Europe and across the world, the textbook is a must read for cardiologists dealing with acute and chronic coronary syndromes, atrial fibrillation, artificial heart valves and pulmonary embolism. It will also appeal to cardiac surgeons, cardiovascular researchers, and general physicians alike.

• The ESC Textbook of Thrombosis is the third iteration of Therapeutic Advances in Thrombosis. Now a new addition to the European Society of Cardiology (ESC) publications portfolio.
• Written by internationally renowned experts in the field of thrombosis.
• It reflects contemporary European guidelines from the ESC and summarizes the latest evidence from clinical trials.
• Split into four sections: Pathophysiology of thrombosis, Clinical pharmacology of antithrombotic drugs, Therapeutic strategies, and Special situations.
• Appealing to the large community of cardiovascular healthcare specialists in Europe and across the world, the textbook is a must read for cardiologists dealing with acute and chronic coronary syndromes, atrial fibrillation, artificial heart valves and pulmonary embolism.

1: Introduction, Raffaele De Caterina, David J. Moliterno, and Steen Dalby Kristensen
Section 1: Pathophysiology of thrombosis
2: Arterial thrombosis: Pathophysiological background, Lina Badimon and Gemma Vilahur
3: Venous thrombosis and thromboembolism: Pathophysiological background, Marcello Di Nisio, Nicola Potere, Harry R. Buller, and Nick van Es
4: Thrombosis & thromboembolism in atrial fibrillation: Pathophysiological background, Peter Calvert, Nicola Tidbury, and Gregory Y. H. Lip
5: Thrombosis on foreign surfaces and devices, Tobias Geisler
Section 2: Clinical pharmacology of antithrombotic drugs
6: Aspirin, Carlo Patrono and Bianca Rocca
7: Platelet P2Y12 inhibitors, Manan Pareek and Deepak L. Bhatt
8: Dipyridamole, cilostazol, GP IIb/IIIa inhibitors, and PAR-1 antagonists, Luis Ortega-Paz and Dominick Angiolillo
9: Heparins, fondaparinux, hirudin, bivalirudin, argatroban and danaparoid, Renske Olie and Hugo ten Cate
10: Vitamin K antagonists, Freek W. A. Verheugt and Marc Brouwer
11: Dabigatran, Alex Benz and Stefan Hohnloser
12: Oral factor Xa (FXa) inhibitors, Lars C. Wallentin, Agneta Siegbahn, Peter Svensson, and Hakan Wallen
13: Forthcoming oral factor XIa and FXIIa inhibitors, James C. Fredenburgh and Jeffrey I. Weitz
14: Thrombolytic therapy and ancillary antithrombotic therapies, Peter R Sinnaeve and Frans Van de Werf
Section 3: Therapeutic strategies
15: Antithrombotic strategies in primary cardiovascular prevention, Raffaele De Caterina, Paul M Ridker, and Erica Michelotti
16: Antithrombotic strategies in patients undergoing elective percutaneous coronary interventions and in chronic coronary syndromes without interventions, Antonio Greco and Davide Capodanno
17: Antithrombotic therapy in ST-elevation acute myocardial infarction and non-ST elevation acute coronary syndromes, William A. E. Parker, Raffaele De Caterina, David J. Moliterno, Steen Dalby Kristensen and Robert F. Storey
18: Anti-thrombotic therapy for patients with prosthetic valves and during structural percutaneous interventions, Naoki Misumida, Mohamad Alkhouli, and David J. Moliterno
19: Antithrombotic therapies in ischaemic stroke, Hans Christoph Diener, Graeme J. Hankey, and John W. Eikelboom
20: Antithrombotic therapy in patients with patent foramen ovale (PFO), PFO closure, left ventricular mural thrombus, atrial thrombus, and catheter-related thrombosis, Jens Erik Nielsen-Kudsk, Kasper Korsholm, Asger Andersen, and Erik Lerkevang Grove
21: Atrial fibrillation: current and forthcoming antithrombotic therapies, Raffaele De Caterina and Rossella Marcucci
22: Venous thromboembolism: prophylaxis and treatment, Chaozer Er, Walter Ageno, and Ander Cohen
23: Biomarker-based risk stratification in cardiovascular disease, Lars C. Wallentin, Ziad Hijazi, Gorav Bartra, and Johan Lindbäck
Section 4: Special situations
24: Antithrombotic therapies in inherited or acquired thrombophilia, Vittorio Pengo and Gentian Denas
25: Prevention and treatment of bleeding related to antithrombotic drug treatment, Roxana Mehran, Alessandro Spirito, George Dangas, and David Cao
26: Management of patients treated with antithrombotic drugs undergoing surgery, Michael Maeng, Steen Dalby Kristensen, and Jolanta M. Siller-Matula
27: Antithrombotic therapy in patients with atrial fibrillation and recent coronary stenting, with or without an acute coronary syndrome, Alexander C Fanaroff, Renato D Lopes, John H Alexander
28: Prevention and treatment of venous and arterial thrombosis in patients with specific conditions: diabetes, renal insufficiency, thrombophilia and pregnancy, Stefan Agewall, Vanessa Roldán, and Francisco Marín
29: Antithrombotic agents and drug-drug interactions, Steven P. Dunn, Craig J. Beavers, and David J. Moliterno
30: Personalised antithrombotic therapy: Measuring individual variation and monitoring, Jur ten Berg, Dirk Sibbning, Wout W. A. van den Broek, and Konstantinos D. Rizas
31: Drug development, clinical trials, and regulatory requirements, Serge Korjian, Yazan Daaboul, and C. Michael Gibson

Raffaele De Caterina, Director, Chair and School of Specialization in Diseases of the Cardiovascular System, Cardiovascular Division, Pisa University Hospital, and University of Pisa, Pisa, Italy, David Moliterno, Professor of Medicine in the Department of Internal Medicine, Division of Cardiovascular Medicine, Gill Heart and Vascular Institute, University of Kentucky, Lexington, Kentucky, USA, and Steen Kristensen, Consultant Cardiologist and Head of the Cardiovascular Research Centre, Department of Cardiology, Aarhus University Hospital Skejby, Denmark

Raffaele De Caterina is Professor of Cardiology at the University of Pisa, and Director, University Cardiology Division, at Pisa University Hospital. He is also Scientific Advisor for the "G. Monasterio" Foundation, Pisa, Italy. He has been Vice-President of the European Society of Cardiology (2008-2010) and President (2009-2013) of the International Society on Nutrigenetics/Nutrigenomics. He is the past-Editor-in-Chief of the journal Vascular Pharmacology, curent Executive Editor of European Heart Journal, and author of >600 peer-reviewed manuscripts. Major research interests: Cardiovascular Pharmacology, Atrial Fibrillation, Coronary Artery Disease, Cardiovascular Thrombosis, Nutrigenetics and Nutrigenomics.

David J. Moliterno, MD (FESC, FACC, FSCAI, FAHA) is a Professor at the University of Kentucky. He was an attending cardiologist at the Cleveland Clinic for 10 years before joining the University of Kentucky, where he was chief of cardiovascular medicine and subsequently chair of internal medicine. Dr. Moliterno has been a visiting professor or lecturer in more than 30 countries. He is the author of over 400 publications and editor of 8 textbooks. He has been the primary author of publications in BMJ, Circulation, EHJ, JACC, JAMA, Lancet, and NEJM. He is currently the Editor-in-Chief for the JACC: Cardiovascular Interventions and serves on the advisory board of the US FDA. As a clinical researcher, Dr. Moliterno has been a leader in numerous multinational investigational studies. Collectively, these studies have involved over $1 billion in clinical trial research. His primary interests involve acute coronary syndromes, antithrombotic therapies, and interventional cardiology.

Steen Dalby Kristensen is a professor and interventional cardiologist at Aarhus University Hospital, Denmark. Scientific/clinical interests: Thrombosis and anti-thrombotic treatment. Coronary artery disease and acute cardiac care. Percutaneous coronary interventions. Author of more than 365 scientific papers and 17 book chapters. Editor of 5 textbooks. Editor of European Heart Journal, Thrombosis and Haemostasis and European Heart Journal: Acute Cardiovascular Care. Invited speaker in more than 40 different countries. Supervisor of 15 PhD students. Chair of international research committees for evaluation of scientific applications in Germany and Spain. Evaluator of grants in Sweden, Norway, Italy, Germany, Spain, Finland and Denmark. Has been ESC Vice-president, ESC secretary/treasurer and leader of several key ESC initiatives, ESC committees and working groups. Past President of the Danish Society of Cardiology

Contributors:

Walter Ageno
Dipartimento di Medicina e Chirurgia, Università degli Studi dell'Insubria, Varese, Italy
Stefan Agewall
Department of Clinical Sciences, Danderyd Hospital, Karolinska Institutet, Stockholm, Sweden; Institute of Clinical Sciences, University of Oslo, Oslo, Norway
John H. Alexander
Division of Cardiology and Duke Clinical Research Institute, Duke University, Durham, North Carolina, USA
Mohamad Alkhouli
Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, USA
Asger Andersen
Department of Cardiology, Aarhus University Hospital, Aarhus; Institute of Clinical Medicine, Faculty of Health, Aarhus University, Aarhus, Denmark
Dominick J. Angiolillo
Division of Cardiology, University of Florida College of Medicine, Jacksonville, Florida, USA
Lina Badimon
Cardiovascular Program-ICCC, IR-Hospital de la Santa Creu i Sant Pau-IIB SantPau and CiberCV, Barcelona, Spain
Gorav Batra
Department of Medical Sciences, Cardiology, and Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden
Craig J. Beavers
Department of Pharmacy Practice and Science, University of Kentucky, College of Pharmacy, Lexington, Kentucky, USA
Alexander P. Benz
Department of Cardiology, University Medical Center Mainz, Johannes Gutenberg-University, Mainz, Germany; Population Health Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, Ontario, Canada
Deepak L. Bhatt
Mount Sinai Heart, Icahn School of Medicine at Mount Sinai Health System, New York, NY, USA
Marc A. Brouwer
Department of Cardiology, Radboud University Medical Center, Nijmegen, The Netherlands
Harry R. Buller
Department of Vascular Medicine, Amsterdam University Medical Center, Amsterdam, The Netherlands
Peter Calvert
Liverpool Centre for Cardiovascular Science at University of Liverpool, Liverpool John Moores University and Liverpool Heart & Chest Hospital, Liverpool; Liverpool Heart & Chest NHS Foundation Trust, Liverpool, UK
Davide Cao
Center for Interventional Cardiovascular Research and Clinical Trials, Mount Sinai Heart, Icahn School of Medicine at Mount Sinai Health System, New York, NY, USA; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele-Milan, Italy
Davide Capodanno
Division of Cardiology, Azienda Ospedaliero-Universitaria Policlinico 'G. Rodolico - San Marco', University of Catania, Catania, Italy
Raffaele De Caterina
Cardiovascular Division, Pisa University Hospital, and University of Pisa, Pisa, Italy
Alexander T. Cohen
Department of Haematological Medicine, Guy's and St Thomas' NHS Foundation Trust, King's College London, London, UK
Yazan Daaboul
Division of Cardiovascular Diseases, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston; Baim Institute for Clinical Research, Boston, Massachusetts, USA
George Dangas
Center for Interventional Cardiovascular Research and Clinical Trials, Mount Sinai Heart, Icahn School of Medicine at Mount Sinai Health System, New York, NY, USA
Gentian Denas
Thrombosis Research Laboratory, Cardiology Clinic University of Padova, Padova, Italy
Marcello Di Nisio
Department of Medicine and Ageing Sciences, University 'G. d'Annunzio' of Chieti-Pescara, Chieti, Italy
Hans Christoph Diener
Department of Neuroepidemiology, Institute for Medical Informatics, Biometry and Epidemiology, Medical Faculty of the University Duisburg-Essen, Essen, Germany
Steven P. Dunn
Department of Pharmacy Services and Division of Cardiovascular Medicine, UVA Health, University of Virginia, Charlottesville, Virginia, USA
John W. Eikelboom
Department of Medicine, McMaster University, Hamilton, and Population Health Research Institute, Hamilton, Canada
Chaozer Er
Department of General Medicine, Woodlands Health, Singapore
Alexander C. Fanaroff
Penn Cardiovascular Outcomes, Quality and Evaluative Research Center, Leonard Davis Institute, and Cardiovascular Medicine Division, University of Pennsylvania, Philadelphia, USA
James C. Fredenburgh
Department of Medicine, McMaster University, Hamilton; Thrombosis and Atherosclerosis Research Institute, McMaster University, Hamilton, Ontario, Canada
Tobias Geisler
Department of Cardiology and Angiology, University Hospital Tübingen, Germany
C. Michael Gibson
Division of Cardiovascular Diseases, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston; Baim Institute for Clinical Research, Boston, Massachusetts, USA
Antonio Greco
Division of Cardiology, Azienda Ospedaliero-Universitaria Policlinico 'G. Rodolico - San Marco', University of Catania, Catania, Italy
Erik Lerkevang Grove
Department of Cardiology, Aarhus University Hospital, Aarhus; Department of Clinical Medicine, Health, Aarhus University, Aarhus, Denmark
Graeme J. Hankey
Perron Institute for Neurological and Translational Science, Perth; Medical School, Centre for Neurological and Neuromuscular Diseases, The University of Western Australia, Perth, Australia
Ziad Hijazi
Department of Medical Sciences, Cardiology, and Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden
Stefan H. Hohnloser
Department of Cardiology, J. W. Goethe University, Frankfurt, Germany
Serge Korjian
Division of Cardiovascular Diseases, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston; Baim Institute for Clinical Research, Boston, Massachusetts, USA
Kasper Korsholm
Department of Cardiology, Aarhus University Hospital, Aarhus; Institute of Clinical Medicine, Faculty of Health, Aarhus University, Aarhus, Denmark
Steen Dalby Kristensen
Department of Cardiology, Aarhus University Hospital, Aarhus; Department of Clinical Medicine, Health, Aarhus University, Aarhus, Denmark
Johan Lindbäck
Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden
Gregory Y. H. Lip
Liverpool Centre for Cardiovascular Science at University of Liverpool, Liverpool John Moores University and Liverpool Heart & Chest Hospital, Liverpool, UK; Danish Center for Clinical Health Services Research, Department of Clinical Medicine, Aalborg University, Aalborg, Denmark
Renato D. Lopes
Division of Cardiology and Duke Clinical Research Institute, Duke University, Durham, North Carolina, USA
Michael Maeng
Department of Cardiology, Aarhus University Hospital, Aarhus; Department of Clinical Medicine, Health, Aarhus University, Aarhus, Denmark
Rossella Marcucci
Department of Experimental and Clinical Medicine, University of Florence and Atherothrombosis Center, Careggi Hospital, Florence, Italy
Francisco Marín
Hospital Clínico Universitario Virgen de la Arrixaca, University of Murcia, IMIB-Arrixaca, CIBERCV, Murcia, Spain
Roxana Mehran
Center for Interventional Cardiovascular Research and Clinical Trials, Mount Sinai Heart, Icahn School of Medicine at Mount Sinai Health System, New York, NY, USA
Erica Michelotti
Cardiovascular Division, Pisa University Hospital, and University of Pisa, Pisa, Italy
Naoki Misumida
Division of Cardiovascular Medicine, Gill Heart and Vascular Institute, University of Kentucky, Lexington, Kentucky, USA
David J. Moliterno
Division of Cardiovascular Medicine, Gill Heart and Vascular Institute, University of Kentucky, Lexington, Kentucky, USA
Jens Erik Nielsen-Kudsk
Department of Cardiology, Aarhus University Hospital, Aarhus; Institute of Clinical Medicine, Faculty of Health, Aarhus University, Aarhus, Denmark
Renske H. Olie
Department of Internal Medicine and Thrombosis Expertise Center, Maastricht University Medical Center, Maastricht; Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, The Netherlands
Luis Ortega-Paz
Division of Cardiology, University of Florida College of Medicine, Jacksonville, Florida, USA
Manan Pareek
Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen and Copenhagen University Hospital - Herlev and Gentofte, Copenhagen; Department of Cardiology, The Heart Center, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark
William A. E. Parker
Cardiovascular Research Unit, University of Sheffield, Sheffield, UK
Carlo Patrono
Division of Pharmacology, Department of Safety and Bioethics, Catholic University School of Medicine, Rome, Italy
Vittorio Pengo
Thrombosis Research Laboratory, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, Padova, and Arianna Foundation on Anticoagulation, Bologna, Italy
Nicola Potere
Department of Medicine and Ageing Sciences, Center for Advanced Studies and Technology, 'G. d'Annunzio' University, Chieti, Italy
Paul M. Ridker
Center for Cardiovascular Disease Prevention, Divisions of Preventive Medicine and Cardiovascular Diseases, Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts, USA
Konstantinos D. Rizas
Medizinische Klinik und Poliklinik I, LMU University Hospital Munich, Munich; German Centre for Cardiovascular Research (DZHK), partner site Munich Heart Alliance, Munich, Germany
Bianca Rocca
Division of Pharmacology, Department of Safety and Bioethics, Catholic University School of Medicine, Rome, Italy
Vanessa Roldán
Hospital Universitario Morales Meseguer, University of Murcia, Murcia, Spain
Dirk Sibbing
Privatklinik Lauterbacher Mühle am Ostersee, Seeshaupt & Medizinische Klinik und Poliklinik I, LMU University Hospital Munich, Munich; German Centre for Cardiovascular Research (DZHK), partner site Munich Heart Alliance, Munich, Germany
Agneta Siegbahn
Department of Medical Sciences, Clinical Chemistry, and Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden
Jolanta M. Siller-Matula
Department of Internal Medicine II, Division of Cardiology, Medical University of Vienna, Vienna, Austria
Peter R. Sinnaeve
Department of Cardiovascular Medicine, University Hospitals Leuven, and Department of Cardiovascular Sciences, University of Leuven, Belgium
Alessandro Spirito
Center for Interventional Cardiovascular Research and Clinical Trials, Mount Sinai Heart, Icahn School of Medicine at Mount Sinai Health System, New York, NY, USA
Robert F. Storey
Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, UK
Peter J. Svensson
Department of Translational Medicine Clinical Coagulation Research Unit, Skåne University Hospital, Lund University, Malmö, Sweden
Jur M. ten Berg
St. Antonius Hospital, Department of Cardiology, Nieuwegein, and Cardiovascular Research Institute Maastricht (CARIM), Maastricht, The Netherlands
Hugo ten Cate
Department of Internal Medicine and Thrombosis Expertise Center, Maastricht University Medical Center, Maastricht; Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, The Netherlands
Nicola Tidbury
Liverpool Centre for Cardiovascular Science at University of Liverpool, Liverpool John Moores University and Liverpool Heart & Chest Hospital, Liverpool; Liverpool Heart & Chest NHS Foundation Trust, Liverpool, UK
Frans Van de Werf
Department of Cardiovascular Medicine, University Hospital Leuven, and Department of Cardiovascular Sciences, University of Leuven, Belgium
Wout W. A. van den Broek
St. Antonius Hospital, Department of Cardiology, Nieuwegein, The Netherlands
Nick van Es
Department of Vascular Medicine, Amsterdam University Medical Center, Amsterdam, The Netherlands
Freek W. A. Verheugt
Department of Cardiology, Heartcenter, Onze Lieve Vrouwe Gasthuis, Amsterdam, The Netherlands
Gemma Vilahur
Cardiovascular Program-ICCC, IR-Hospital de la Santa Creu i Sant Pau-IIB SantPau and CiberCV, Barcelona, Spain
Håkan Wallén
Division of Cardiovascular Medicine, Department of Clinical Sciences, Danderyd Hospital, Karolinska Institutet, Stockholm, Sweden
Lars C. Wallentin
Department of Medical Sciences, Cardiology, and Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden
Jeffrey I. Weitz
Department of Medicine, McMaster University, Hamilton; Thrombosis and Atherosclerosis Research Institute, McMaster University, Hamilton; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada

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