Diastology: Clinical Approach to Heart Failure with Preserved Ejection Fraction

Accounting for more than 40% of all heart failure problems, diastolic heart failure is a complex and often difficult diagnosis with rapidly evolving diagnostic management protocols. Diastology: Clinical Approach to Heart Failure with Preserved Ejection Fraction, 2nd Edition, brings you up to date and equips you to successfully diagnose and manage even the most challenging incidences of diastolic heart failure and their comorbidities. It incorporates the latest guidelines for the diagnostic evaluation of the patient with suspected or known diastolic dysfunction, provides a comprehensive review of clinical conditions associated with heart failure with preserved ejection fraction, and describes the complementary role of imaging modalities and novel therapeutic approaches.

Key Features

• Keeps you current with recent extensive changes in the understanding of the mechanisms of diastolic heart failure with preserved ejection fraction (HFpEF) that have resulted in dramatic changes in treatment guidelines.
• Covers the latest molecular, genetic, and cellular mechanisms behind diastolic heart failure as a basis for the latest clinical approaches, diagnosis, and treatment of common and uncommon pathological conditions such as hypertensive heart disease, cardiomyopathies, arterial and valvular diseases, pericardial diseases, congenital heart disease, diabetes mellitus, and metabolic syndrome.
• Features 50 video cases, new key summary points, new multiple-choice review questions, and six new chapters: Evaluation of Diastolic Function by Radionuclide Techniques; Diastology Stress Test; ASE/EACVI Diastolic Guidelines; Valve Disease; Perioperative Assessment of Diastolic Dysfunction; and Pulmonary Hypertension.
• Reviews new techniques and indices for assessing diastolic function, such as 3D echo, strain rate imaging, late gadolinium enhancement and T1-mapping by CMR, and novel nuclear scintigraphic methods – as well as the traditional indices of LV filling, LA function, and tissue Doppler indices.
• Covers emerging topics such as the role of neurohormones, global and regional systolic function of the left ventricle, chronotopic incompetence and pacing, aging, perioperative assessment, and more.
• Presents information in a quick-retrieval format, covering Epidemiology, Pathophysiology, Diagnostic Evaluation, Differential Diagnosis, Treatment, and Future Directions.
• Helps you learn efficiently and prepare for self-assessment with key summaries and multiple-choice questions and answers for each chapter.
• Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

Part I: Basic Determinants of Diastolic Function

1. Molecular, Gene, and Cellular Mechanis
2. Pathophysiology of Heart Failure With a Preserved Ejection Fraction: Measurements and Mechanisms Causing Abnormal Diastolic Function
3. Role of the Pericardium in Diastolic Dysfunction
4. Left Atrial Function: Basic Physiology
5. Physical Determinants of Diastolic Flow
6. Ventricular-Arterial Interaction in Patients With Heart Failure and a Preserved Ejection Fraction Part II: Diagnosis of Heart Failure With Preserved Ejection Fraction
7. General Principles, Clinical Definition, Epidemiology, and Pathophysiology
8. Invasive Hemodynamic Assessment in Heart Failure With Preserved Ejection Fraction
9. Two-Dimensional and Doppler Evaluation of Left Ventricular Filling, Including Pulmonary Venous Flow Velocity
10. Evaluation of Diastolic Function by Tissue Doppler, Strain, and Torsion Analysis
11. Color M-mode Doppler
12. Assessment of Left Atrial Size and Function
13. Evaluation of Intracardiac Filling Pressures
14. Evaluation of Right Ventricular Diastolic Function
15. Evaluation of Diastolic Function by Cardiac Magnetic Resonance Imaging
16. Evaluation of Diastolic Function by Radionuclide Techniques
17. Diastolic Echocardiographic Examination
18. Diastology Stress Test
19. ASE/EACVI Diastolic Guidelines: Strength and Limitations Part III: Cardiac Diseases With HFpEF
20. Hypertension and Its Relation to Heart Failure With a Preserved Ejection Fraction
21. Valve Disease
22. Stage D Heart Failure With Preserved Ejection Fraction, Heart Transplantation, and Mechanical Circulatory Support
23. Primary Restrictive, Infiltrative, and Storage Cardiomyopathies
24. Coronary Artery Disease
25. Hypertrophic Cardiomyopathy
26. Pericardial Diseases: Constrictive Pericarditis and Pericardial Effusion
27. Diastolic Function in Children and in Children With Congenital Heart Disease
28. Diabetes Mellitus Part IV: Emerging Topics in HFpEF
29. Global and Regional Systolic Function of the Left Ventricle
30. Chronotropic Incompetence and Pacing in HPEF Heart Failure with Preserved Ejection Fraction
31. Aging and Heart Failure With Preserved Ejection Fraction
32. Perioperative Assessment of Diastolic Function
33. Pulmonary Hypertension in Heart Failure With Preserved Ejection Fraction Part V: Treatment of HFpEF
34. General Treatment of Heart Failure With Preserved Ejection Fraction and Randomized Trials
35. Echo-Based Approach to the Management of Heart Failure With Preserved Ejection Fraction
36. Future Therapies in HFpEF Part VI: Cases of Diastolic Heart Failure
37. Cases of Diastolic Heart Failure

Author Information

By Allan L. Klein, MD, Department of Cardiovascular Medicine, The Cleveland Clinic, Cleveland, OH and Mario J. Garcia, MD, FACC, Mario J. Garcia, MD, FACC Chief, Division of Cardiology Professor of Medicine and Radiology Co-Director, Montefiore-Einstein Center for Heart and Vascular Care Bronx, New York

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