Diagnostic Pathology: Infectious Diseases

This expert volume in the Diagnostic Pathology series is an excellent point-of-care resource for practitioners at all levels of experience and training. Covering all aspects of infectious diseases, including novel infections and lesser-known microorganisms, this volume incorporates the most recent scientific and technical knowledge in the field to provide a comprehensive overview of all key issues relevant to today’s practice. Richly illustrated and easy to use, the third edition of Diagnostic Pathology: Infectious Diseases is a visually stunning, one-stop resource for every practicing pathologist, resident, student, or fellow as an ideal day-to-day reference or as a reliable training resource.

New to this edition

Expanded text throughout the 3rd edition, including Expanded introductory section with -Updated biosafety chapter (issues in frozen section room, gross room, and at autopsy)-Novel/emerging diagnostic techniques (whole slide imaging with AI; mass spec imaging, metagenomic next gen sequencing-Chapters on most >> least common infections of CNS, head & neck, skin/soft tissue, pulmonary, cardiac, GI, GU, and GYN systems plus best approach for diagnostic work upNew or split/expanded existing chapters for specific infections, including-COVID-19: acute and post-acute infections, variants of concern, effect on all organ systems-Monkeypox-Separate Burili ulcer (Mycobacterium ulcerans infection)-Separate Burili ulcer (Mycobacterium ulcerans infection)4 NEW additional nematode chapters3 NEW additional trematode chapters2 NEW additional cestode chapters Additional NEW fungal chapters which include culture plate, lactophenol blue, and cytology images for eachNEW detailed tick identification chapter

Key Features

• Covers all areas of infectious disease pathology, including infections of the central nervous system, head and neck, and skin/soft tissue as well as the pulmonary, cardiac, gastrointestinal, genitourinary, and gynecologic systems
• Includes new chapters on COVID-19 and mpox, nine new helminth chapters, additional new fungal chapters, an updated biosafety chapter, and more
• Contains significantly updated information throughout, including new content on artificial intelligence, whole-slide and mass spectrometry imaging, and metagenomic next-generation sequencing
• Discusses the best approach for diagnostic work-up and addresses the challenges in maximizing diagnostic yield while avoiding misinterpretation of results that could lead to false positives
• Details the increasing use of molecular diagnostics in infectious disease pathology
• Provides updates on taxonomy and nomenclature across all classes of infectious microorganisms (bacteria, fungi, parasites, viruses) along with new genomic data
• Features more than 1, 500 print and online-only images, including histology and gross pathology images, full-color medical illustrations, clinical photographs, and radiology images to help practicing and in-training pathologists reach a confident diagnosis
• Employs consistently templated chapters, bulleted content, key facts, a variety of tables, annotated images, pertinent references, and an extensive index for quick, expert reference at the point of care
• Includes an eBook version that enables you to access all text, figures, and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud. Additional digital ancillary content may publish up to 6 weeks following the publication date

SECTION 1: OVERVIEW 4 Standard Methods for Infectious Diseases Zoe Freeman Weiss, MD, Nicole Pecora, MD, PhD, and Shira Winters, MD 10 Emerging Techniques Jessica Crothers, MD 12 Biosafety Considerations Jessica Crothers, MD 16 Pitfalls and Artifacts Jessica Crothers, MD, Alvaro C. Laga, MD, MMSc, and Isaac Solomon, MD, PhD SECTION 2: VIRAL INFECTIONS DNA VIRUSES 22 Herpes Simplex Virus 1 and 2 (HSV-1, HSV-2) Infections Isaac Solomon, MD, PhD, Leigh Compton, MD, and Dan A. Milner, MSc(Epi), MBA 28 Varicella-Zoster Virus (HHV-3) Infections Isaac Solomon, MD, PhD, Eleanor Russell-Goldman, MD, PhD, and Dan A. Milner, MSc(Epi), MBA 32 Epstein-Barr Virus (HHV-4) Infection Isaac Solomon, MD, PhD and Dan A. Milner, MSc(Epi), MBA 38 Cytomegalovirus (HHV-5) Infections Isaac Solomon, MD, PhD and Dan A. Milner, MSc(Epi), MBA 44 Human Herpesvirus 6 and 7 (HHV-6, HHV-7) Infections Isaac Solomon, MD, PhD 46 Kaposi Sarcoma-Associated Herpesvirus (HHV-8) Infection Isaac Solomon, MD, PhD, Leigh Compton, MD, and Dan A. Milner, MSc(Epi), MBA 52 Herpes B Virus Infection Isaac Solomon, MD, PhD 54 Adenovirus Infection Isaac Solomon, MD, PhD and Dan A. Milner, MSc(Epi), MBA 58 Hepatitis B and D Virus Infections Isaac Solomon, MD, PhD and Dan A. Milner, MSc(Epi), MBA 62 Parvovirus B19 Infection Isaac Solomon, MD, PhD, Leigh Compton, MD, and Dan A. Milner, MSc(Epi), MBA 66 JC Virus, BK Virus, and Other Polyomavirus Infections Isaac Solomon, MD, PhD RNA VIRUSES 86 Arbovirus Infections Isaac Solomon, MD, PhD 92 Zika Virus Infection Isaac Solomon, MD, PhD and Dan A. Milner, MSc(Epi), MBA 96 Ebola, Marburg, and Other Hemorrhagic Fever Virus Infections Isaac Solomon, MD, PhD and Dan A. Milner, MSc(Epi), MBA 102 Enterovirus Infections Isaac Solomon, MD, PhD and Dan A. Milner, MSc(Epi), MBA 104 Poliovirus Infection Jessica Crothers, MD and Isaac Solomon, MD, PhD 106 Rabies Virus Infection Isaac Solomon, MD, PhD 108 Lymphocytic Choriomeningitis Virus Infection Isaac Solomon, MD, PhD 110 Measles Virus Infection Isaac Solomon, MD, PhD 112 Mumps Virus Infection Isaac Solomon, MD, PhD 114 Rubella Virus Infection Isaac Solomon, MD, PhD 116 Human Immunodeficiency Virus Infection Isaac Solomon, MD, PhD and Dan A. Milner, MSc(Epi), MBA 120 Human T-Lymphotropic Virus Type I Infection Isaac Solomon, MD, PhD and Dan A. Milner, MSc(Epi), MBA 122 Influenza Virus Infections Isaac Solomon, MD, PhD 126 Parainfluenza Virus Infections Isaac Solomon, MD, PhD 128 Coronavirus Disease 2019 (COVID-19) Isaac Solomon, MD, PhD 134 Severe Acute Respiratory Syndrome (SARS), Middle East Respiratory Syndrome (MERS), and Other Coronavirus Infections Isaac Solomon, MD, PhD 136 Respiratory Syncytial Virus Infection Isaac Solomon, MD, PhD and Eleanor Russell-Goldman, MD, PhD 138 Rhinoviruses, Human Metapneumovirus, and Other Respiratory Virus Infections Isaac Solomon, MD, PhD 140 Rotavirus, Norovirus, and Astrovirus Infections Isaac Solomon, MD, PhD 142 Hepatitis A and E Virus Infections Isaac Solomon, MD, PhD 146 Hepatitis C Virus Infection Isaac Solomon, MD, PhD, Eleanor Russell-Goldman, MD, PhD, and Dan A. Milner, MSc(Epi), MBA SECTION 3: PRION DISEASES 152 Transmissible Spongiform Encephalopathies Isaac Solomon, MD, PhD SECTION 4: BACTERIAL INFECTIONS 158 Bacterial Classification and Diagnosis Nicole Pecora, MD, PhD 160 Botryomycosis Isaac Solomon, MD, PhD and Malak Abedalthagafi, MD, MBA 162 Malakoplakia Malak Abedalthagafi, MD, MBA and Leigh Compton, MD GRAM-POSITIVE BACTERIA 164 Actinomycosis Isaac Solomon, MD, PhD, Nicole Pecora, MD, PhD, and Leigh Compton, MD 166 Bacillus Species Infections Zoe Freeman Weiss, MD and Nicole Pecora, MD, PhD 170 Clostridioides and Other Gram-Positive Anaerobes Nicole Pecora, MD, PhD and Zoe Freeman Weiss, MD 174 Corynebacterium Species Infections Nicole Pecora, MD, PhD 178 Listeria Species Infection Zoe Freeman Weiss, MD and Nicole Pecora, MD, PhD 180 Rhodococcus Species Infection Zoe Freeman Weiss, MD and Nicole Pecora, MD, PhD 182 Staphylococcus Species Infections Zoe Freeman Weiss, MD and Nicole Pecora, MD, PhD 188 Streptococcus and Enterococcus Species Infections Zoe Freeman Weiss, MD and Nicole Pecora, MD, PhD 192 Whipple Disease Jessica Crothers, MD, Dan A. Milner, MSc(Epi), MBA, and Isaac Solomon, MD, PhD GRAM-NEGATIVE BACTERIA 196 Pathologically Important Enterobacterales: Escherichia, Shigella, Salmonella, Klebsiella, and Yersinia Species Infections Nicole Pecora, MD, PhD and Zoe Freeman Weiss, MD 204 Fastidious Organisms: Brucella, Francisella, Haemophilus, and Legionella Species Infections Nicole Pecora, MD, PhD 210 Nonfermentative Organisms: Acinetobacter, Burkholderia, and Pseudomonas Species Infections Zoe Freeman Weiss, MD, Nicole Pecora, MD, PhD, and Lenette Lu, MD, PhD 216 Bacteroides, Fusobacterium, and Other Gram-Negative Anaerobes Zoe Freeman Weiss, MD and Nicole Pecora, MD, PhD 220 Bartonella Species Infections Isaac Solomon, MD, PhD and Alvaro C. Laga, MD, MMSc 222 Campylobacter and Vibrio Species Infections Zoe Freeman Weiss, MD and Nicole Pecora, MD, PhD 226 Helicobacteriosis Isaac Solomon, MD, PhD and Dan A. Milner, MSc(Epi), MBA 228 Neisseria and Moraxella Species Infections Nicole Pecora, MD, PhD and Dan A. Milner, MSc(Epi), MBA 232 Pertussis Isaac Solomon, MD, PhD and Dan A. Milner, MSc(Epi), MBA 234 Intestinal Spirochetosis Isaac Solomon, MD, PhD, Leigh Compton, MD, and Nicole Pecora, MD, PhD 236 Borrelia Species Infections Isaac Solomon, MD, PhD and Nicole Pecora, MD, PhD 240 Leptospira Species Infection Isaac Solomon, MD, PhD and Nicole Pecora, MD, PhD 242 Syphilis and Other Treponematoses Alvaro C. Laga, MD, MMSc, Isaac Solomon, MD, PhD, and Dan A. Milner, MSc(Epi), MBA 248 Anaplasmosis and Ehrlichiosis Isaac Solomon, MD, PhD, Nicole Pecora, MD, PhD, and Lenette Lu, MD, PhD 252 Chlamydophila and Chlamydia Species Infections Nicole Pecora, MD, PhD 256 Coxiella Species Infection Isaac Solomon, MD, PhD and Nicole Pecora, MD, PhD 258 Rickettsia and Orientia Species Infections Isaac Solomon, MD, PhD and Nicole Pecora, MD, PhD 262 Mycoplasma and Ureaplasma Species Infections Zoe Freeman Weiss, MD and Isaac Solomon, MD, PhD ACID-FAST BACTERIA 264 Mycobacterium tuberculosis Complex Infections Nicole Pecora, MD, PhD, Isaac Solomon, MD, PhD, and Dan A. Milner, MSc(Epi), MBA 270 Leprosy Malak Abedalthagafi, MD, MBA, Dan A. Milner, MSc(Epi), MBA, and Isaac Solomon, MD, PhD 274 Buruli Ulcer Alvaro C. Laga, MD, MMSc 276 Mycobacterium avium Complex and Other Nontuberculous Mycobacterial Infections Nicole Pecora, MD, PhD and Zoe Freeman Weiss, MD 280 Nocardiosis Isaac Solomon, MD, PhD and Dan A. Milner, MSc(Epi), MBA SECTION 5: FUNGAL INFECTIONS 286 Fungal Classification and Diagnosis Alvaro C. Laga, MD, MMSc and Dan A. Milner, MSc(Epi), MBA MOLDS 290 Aspergillosis Zoe Freeman Weiss, MD, Alvaro C. Laga, MD, MMSc, and Isaac Solomon, MD, PhD 296 Entomophthoramycosis Alvaro C. Laga, MD, MMSc 300 Fusariosis Alvaro C. Laga, MD, MMSc, Zoe Freeman Weiss, MD, and Nicole Pecora, MD, PhD 302 Mucormycosis Zoe Freeman Weiss, MD, Alvaro C. Laga, MD, MMSc, and Isaac Solomon, MD, PhD 306 Mycetoma Alvaro C. Laga, MD, MMSc, T. Rinda Soong, MD, PhD, MPH, and Brian J. Hall, MD 310 Phaeohyphomycosis Alvaro C. Laga, MD, MMSc, Dan A. Milner, MSc(Epi), MBA, and Isaac Solomon, MD, PhD 312 Scedosporiosis and Lomentosporiosis Alvaro C. Laga, MD, MMSc, Zoe Freeman Weiss, MD, and Eleanor Russell-Goldman, MD, PhD 314 Scopulariopsis Infections Zoe Freeman Weiss, MD, Alvaro C. Laga, MD, MMSc, and Eleanor Russell-Goldman, MD, PhD 316 Tineasis Malak Abedalthagafi, MD, MBA, Leigh Compton, MD, and Isaac Solomon, MD, PhD 318 Trichosporonosis Isaac Solomon, MD, PhD, Alvaro C. Laga, MD, MMSc, and Dan A. Milner, MSc(Epi), MBA 320 Superficial Mycoses Alvaro C. Laga, MD, MMSc YEAST AND YEAST-LIKE ORGANISMS 324 Blastomycosis Jessica Crothers, MD 330 Candidiasis Jessica Crothers, MD, T. Rinda Soong, MD, PhD, MPH, and Isaac Solomon, MD, PhD 336 Chromoblastomycosis Alvaro C. Laga, MD, MMSc, T. Rinda Soong, MD, PhD, MPH, and Nicole Pecora, MD, PhD 340 Coccidioidomycosis Malak Abedalthagafi, MD, MBA and Isaac Solomon, MD, PhD 344 Cryptococcosis Alvaro C. Laga, MD, MMSc, T. Rinda Soong, MD, PhD, MPH, and Isaac Solomon, MD, PhD 350 Histoplasmosis Alvaro C. Laga, MD, MMSc, T. Rinda Soong, MD, PhD, MPH, and Nicole Pecora, MD, PhD 356 Lobomycosis Alvaro C. Laga, MD, MMSc 358 Paracoccidioidomycosis Isaac Solomon, MD, PhD and Eleanor Russell-Goldman, MD, PhD 360 Pneumocystosis Jessica Crothers, MD, Eleanor Russell-Goldman, MD, PhD, and Isaac Solomon, MD, PhD 364 Sporotrichosis Alvaro C. Laga, MD, MMSc, Isaac Solomon, MD, PhD, and Dan A. Milner, MSc(Epi), MBA 368 Talaromycosis Alvaro C. Laga, MD, MMSc, Dan A. Milner, MSc(Epi), MBA, and Isaac Solomon, MD, PhD 370 Rhinosporidiosis Alvaro C. Laga, MD, MMSc 372 Protothecosis Jessica Crothers, MD SECTION 6: PROTOZOAN PARASITIC INFECTIONS 376 Parasite Classification and Diagnosis Alvaro C. Laga, MD, MMSc, Isaac Solomon, MD, PhD, and Dan A. Milner, MSc(Epi), MBA GASTROINTESTINAL AND OTHER LUMINAL PROTOZOA 380 Balantidiasis Isaac Solomon, MD, PhD and Dan A. Milner, MSc(Epi), MBA 382 Cryptosporidiosis and Other Coccidia Infections Isaac Solomon, MD, PhD, Malak Abedalthagafi, MD, MBA, and Dan A. Milner, MSc(Epi), MBA 386 Entamebiasis Malak Abedalthagafi, MD, MBA and Isaac Solomon, MD, PhD 390 Giardiasis Malak Abedalthagafi, MD, MBA, Eleanor Russell- Goldman, MD, PhD, and Isaac Solomon, MD, PhD 392 Microsporidiosis Isaac Solomon, MD, PhD, Malak Abedalthagafi, MD, MBA, and Dan A. Milner, MSc(Epi), MBA 394 Trichomoniasis Isaac Solomon, MD, PhD and T. Rinda Soong, MD, PhD, MPH INTRAVASCULAR PROTOZOA 396 African Trypanosomiasis Isaac Solomon, MD, PhD and Dan A. Milner, MSc(Epi), MBA 398 Babesiosis Malak Abedalthagafi, MD, MBA, Dan A. Milner, MSc(Epi), MBA, and Lenette Lu, MD, PhD 402 Malaria Isaac Solomon, MD, PhD and Dan A. Milner, MSc(Epi), MBA DEEP TISSUE PROTOZOA 408 Free-Living Amebiasis Alvaro C. Laga, MD, MMSc, Isaac Solomon, MD, PhD, and Dan A. Milner, MSc(Epi), MBA 414 American Trypanosomiasis Isaac Solomon, MD, PhD, Malak Abedalthagafi, MD, MBA, and Eleanor Russell-Goldman, MD, PhD 416 Leishmaniasis Malak Abedalthagafi, MD, MBA, Dan A. Milner, MSc(Epi), MBA, and Isaac Solomon, MD, PhD 420 Toxoplasmosis Isaac Solomon, MD, PhD, Malak Abedalthagafi, MD, MBA, and Dan A. Milner, MSc(Epi), MBA SECTION 7: HELMINTHIC PARASITIC INFECTIONS NEMATODES 426 Ancylostomiasis and Necatoriasis Isaac Solomon, MD, PhD and Dan A. Milner, MSc(Epi), MBA 428 Angiostrongyliasis Isaac Solomon, MD, PhD 430 Ascariasis Isaac Solomon, MD, PhD and Dan A. Milner, MSc(Epi), MBA 434 Enterobiasis Jessica Crothers, MD and Isaac Solomon, MD, PhD 438 Gnathostomiasis Alvaro C. Laga, MD, MMSc 440 Human Filariasis Malak Abedalthagafi, MD, MBA, Isaac Solomon, MD, PhD, and Eleanor Russell-Goldman, MD, PhD 444 Onchocerciasis Malak Abedalthagafi, MD, MBA 446 Strongyloidiasis Malak Abedalthagafi, MD, MBA and Isaac Solomon, MD, PhD 450 Trichuriasis Isaac Solomon, MD, PhD and Dan A. Milner, MSc(Epi), MBA 454 Trichinellosis Jessica Crothers, MD TREMATODES 456 Clonorchiasis and Opisthorchiasis Jessica Crothers, MD 460 Fascioliasis and Fasciolopsiasis Jessica Crothers, MD 462 Paragonimiasis Jessica Crothers, MD 464 Schistosomiasis Dan A. Milner, MSc(Epi), MBA and Isaac Solomon, MD, PhD CESTODES 470 Coenurosis Isaac Solomon, MD, PhD 472 Cysticercosis Isaac Solomon, MD, PhD 478 Diphyllobothriasis and Hymenolepiasis Jessica Crothers, MD 482 Echinococcosis Dan A. Milner, MSc(Epi), MBA and Isaac Solomon, MD, PhD 486 Sparganosis Isaac Solomon, MD, PhD SECTION 8: INFESTATIONS AND OTHER INVERTEBRATE-RELATED MALADIES 490 Tissue Damage From Arachnids and Insects Alvaro C. Laga, MD, MMSc, Isaac Solomon, MD, PhD, and Dan A. Milner, MSc(Epi), MBA 498 Myiasis Malak Abedalthagafi, MD, MBA and Dan A. Milner, MSc(Epi), MBA 500 Scabies Malak Abedalthagafi, MD, MBA, Leigh Compton, MD, and Dan A. Milner, MSc(Epi), MBA 502 Demodex Infestations Malak Abedalthagafi, MD, MBA and Dan A. Milner, MSc(Epi), MBA 504 Tungiasis Malak Abedalthagafi, MD, MBA and Dan A. Milner, MSc(Epi), MBA.

Author Information

By Isaac H. Solomon, MD, PhD, Assistant Professor of Pathology, Harvard Medical School, Associate Pathologist, Department of Pathology, Brigham and Women’s Hospital, Boston, Massachusetts, Neurooncology Member, Dana Farber/Harvard Cancer Center, Boston, Massachusetts; Dan Milner, MD, MSc(Epi), MBA, Pathologist, Brigham and Women's Hospital, Assistant Medical Director, Microbiology, Brigham and Women's Hospital and Associate Professor of Pathology, Harvard Medical School, Boston, Massachusetts.

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