A practical guide to cancer genomics and its application to cancer diagnosis and care. Each chapter provides explanations of concepts, terminology, and methods. Also included are tips for interpreting and analysing molecular data, and discussion of molecular predictors for targeted therapies covering haematologic malignancies and solid tumours.
Cancer Genomics for the Clinician is a practical guide to cancer genomics and its application to cancer diagnosis and care. The book begins with a brief overview of the various types of genetic alterations that are encountered in cancer, followed by accessible and applicable information on next generation sequencing technology and bioinformatics, tumor heterogeneity, whole genome, exome and transcriptome sequencing, epigenomics, and data analysis and interpretation. Each chapter provides essential explanations of concepts, terminology, and methods. Also included are tips for interpreting and analyzing molecular data, as well as a discussion of molecular predictors for targeted therapies covering hematologic malignancies and solid tumors. The final chapter explains the use of FDA-approved genomic-based targeted therapies for breast cancer, lung cancer, sarcomas, gastrointestinal cancers, urologic cancers, head and neck cancer, thyroid cancer, and many more.
Assembled in an accessible format specifically designed for the non-expert, this book provides the clinical oncologist, early career practitioner, and trainee with an essential understanding of the molecular and genetic basis of cancer and the clinical aspects that have led to advancements in diagnosis and treatment. With this resource, physicians and trainees will increase their breadth of knowledge and be better equipped to educate patients and families who want to know more about their genetic predispositions to cancer and the targeted therapies that could be considered and prescribed.
- Describes how cancer genomics and next generation sequencing informs cancer screening, risk factors, therapeutic options, and clinical management across cancer types
- Explains what mutations are, what tests are needed, and how to interpret the results
- Provides information on FDA-approved targeted therapies that are being used in the clinic
- Covers different sequencing platforms and technologies and how they perform in research settings
- Includes access to the fully-searchable downloadable eBook
- Chapter One: Introduction to Cancer Genomics
- Deepali Jain, Brett Herzog, and Leonard B. Maggi, Jr.
- Chapter Two: Tumor Mutational Profiling by Next Generation Sequencing
- Samantha N. McNulty, Latisha Love-Gregory, and Jonathan W. Heusel
- Chapter Three: Bioinformatics: What a Clinician Should Know
- Irena Lanc and Arpad Danos
- Chapter Four: Tumor Heterogeneity
- Alex H. Wagner, Kilannin Krysiak, Katie M. Campbell, and Erica K. Barnell
- Chapter Five: Epigenetics Alterations in Cancer
- Erica C. Pehrsson, Hyo Sik Jang, and Ting Wang
- Chapter Six: Cell-Free DNA in Cancer Diagnosis and Follow-Up
- Bruna Pellini Ferreira and Daniel Morgensztern
- Chapter Seven: Optimizing Targeted Therapies Using Next Generation Sequencing
- Brett Herzog and Saiama N. Waqar