Bethesda Handbook of Clinical Hematology

Written by national recognized experts and senior fellows at leading research institutions, including the National Institutes of Health, and edited by Drs. Griffin P. Rodgers and Neal S. Young, The Bethesda Handbook of Clinical Hematology, 5th Edition, is a concise, comprehensive handbook designed for everyday clinical use. Organized in a quick-reference, portable format, it covers the clinical information you need to know for the diagnosis and treatment all of blood and bone marrow disorders. Readable and practical, the Bethesda Handbook features numerous tables, algorithms, illustrations, and bulleted lists throughout to help bridge the gap between cutting-edge science and everyday clinical practice.

• Provides clinically focused, authoritative, and current guidance in this complex area, logically organized by disease category
• Discusses the pathophysiology, natural history, risk factors, diagnosis, management, and follow-up of common hematological diseases
• Features new diagnostic and treatment strategies, updated references, and revised information throughout
• An ideal resource for practitioners at every level of training: students, residents, and fellows on a hematology or oncology service, as well as internists, hospitalists, family practitioners, pediatricians, and nurse practitioners whose practice includes patients with blood diseases

ix
Pr eface...................................................................... vi
Contributors................................................................. vii
Chapter 1 ¦ ir on Defi ciency.................................................... 1
Xing Fan and David J. Young
Chapter 2 ¦ Defi ciencies of Vitamin b
12
and Folate.................................. 12
Arun S. Shet and Griffi n P. Rodgers
Chapter 3 ¦ Hemol ytic Anemia................................................. 23
Dina S. Parekh and Swee Lay Th ein
Chapter 4 ¦ sickle Cell Anemia and thalassemia................................... 41
Matthew M. Hsieh, John F. Tisdale, and Griffi n P. Rodgers
Chapter 5 ¦ P orph yrias....................................................... 64
Zhubin Gahvari and Peiman Hematti
Chapter 6 ¦ bone Marrow Failure syndromes: Aplastic Anemia, Acquired and
Constitutional; Paroxysmal nocturnal Hemoglobinuria; Pure red blood Cell Aplasia; and
Agran ulocytosis.............................................................. 70
Rebecca Bystrom and Bhavisha Patel
Chapter 7 ¦ My elodysplastic syndr omes.......................................... 95
Jibran Durrani, Katherine R. Calvo, and Emma M. Groarke
Chapter 8 ¦ the Myeloproliferative neoplasms: Polycythemia Vera, essential
thrombocythemia, Primary Myelofi brosis, and Chronic Myelomonocytic Leukemia........ 119
M a tt h e w J. O ln es
Chapter 9 ¦ neutrophil Disorders and neutropenias............................... 136
Matthew M. Hsieh and Harry L. Malech
Chapter 10 ¦ Childhood Hematologic Diseases.................................... 147
Christopher C. Denton and Alan S. Wayne
Chapter 11 ¦ Acute Myeloid Leukemia........................................... 165
Rebecca Bystrom and Christopher S. Hourigan
Chapter 12 ¦ Acute Lymphoblastic Leukemia...................................... 186
Eric Nickels, Deepa Bhojwani, and Alan S. Wayne
Chapter 13 ¦ Chronic Myelogenous Leukemia..................................... 200
Agnes S. M. Yong and A. John Barrett
Chapter 14 ¦ Chronic Lymphocytic Leukemia..................................... 218
Andy Itsara, Emily Tomasulo, Adrian Wiestner, and Clare Sun
Chapter 15 ¦ Hodgkin L ymphoma.............................................. 236
Disha Dalela and Mark Roschewski
Chapter 16 ¦ non-Hodgkin L ymphomas......................................... 249
R ic h a r d F. L i tt le
C ON T E N TS x Contents
Chapter 17 ¦ Multiple Myeloma................................................ 276
eha Korde, Sham Mailankody, and Saad Z. Usmani
Chapter 18 ¦ Hematopoietic stem Cell t ransplantation............................. 294
mie Y. Hur and Richard W. Childs
Chapter 19 ¦ thrombocytopenia............................................... 319
Sandhya R. Panch and Cynthia E. Dunbar
Chapter 20 ¦ Disorders of Hemostasis i: Coagulation............................... 340
Meaghan Colling
Chapter 21 ¦ Disorders of Hemostasis ii......................................... 354
Meaghan Colling
Chapter 22 ¦ V enous thromboembolism......................................... 370
edro E. Alcedo and Christopher Pleyer
Chapter 23 ¦ Consultations in Anticoagulation.................................... 386
edro E. Alcedo and W. Keith Hoots
Chapter 24 ¦ blood t ransfusion................................................ 401
mes O. Long and Kathleen (Cathy) Conry-Cantilena
Chapter 25 ¦ Hemochromatosis................................................ 438
inda H. Song, David Daniel, and Susan F. Leitman
Chapter 26 ¦ Consultative Hematology.......................................... 455
ing Fan, Pierre Noel, Charles Bolan, and Arielle L. Langer
Chapter 27 ¦ interpretation of standard Hematologic tests.......................... 477
Disha Dalela, Katherine R. Calvo, and Vid Leko
Chapter 28 ¦ basic Principles and Clinical Applications of Flow Cytometry.............. 502
aul C. Braylan, Thomas A. Fleisher, and Constance M. Yuan
ndex....................................................................... 521

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