Atlas of Gastrointestinal Pathology: A Pattern-Based Approach to Non-Neoplastic Biopsies

Closely mirroring the daily sign-out process, Atlas of Gastrointestinal Pathology: A Pattern-Based Approach to Non-Neoplastic Biopsies, 2nd Edition, by Drs. Maryam Pezhouh and Meredith Pittman, is a highly illustrated, efficient guide to accurate diagnosis. This practical reference uses a proven, pattern-based approach to clearly explain how to interpret challenging cases by highlighting red flags in the clinical chart and locating hidden clues in the slides. Useful as a daily “scope-side guide,” it features numerous clinical and educational features that help you find pertinent information, reach a correct diagnosis, and assemble a thorough and streamlined pathology report.
 
A companion volume for Atlas of Gastrointestinal Pathology is also available and focuses on neoplastic conditions.
 

• More than 1, 000 high-quality, full-color images illustrate the full morphologic spectrum of the major patterns of non-neoplastic GI tract pathology, providing abundant and varied examples of each diagnosis. Each image is captioned with key diagnostic considerations and includes callouts showing subtle features and diagnostic clues.
• Practical tools throughout the text include:
  • Tables that emphasize salient clinicopathologic features, management implications, and therapeutic options
  • Checklists for key elements of the diagnostic approach and sample notes for inclusion in pathology reports
  • Brief reviews of normal histology that provide contrast to succeeding patterns
  • “Pearls and Pitfalls” and “Near Misses” sections with lessons from real life sign-out experience
  • “Frequently Asked Questions” sections that discuss common diagnostic dilemmas
  • “Sample Note” sections that offer a template of how to sign out cases from the simple to the complex
  • Comprehensive quizzes that provide experience with high-yield, board-style teaching topics

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CONTENTS
1 ESOPHAGUS... 1
The Unremarkable Esophagus... 2
Acute Esophagitis Pattern... 7
Gastroesophageal reflux disease... 7
Infections... 10
Medications... 19
Other (malignancy, amyloidosis, radiation injury, and vasculitis)... 30
Eosinophilic Pattern... 32
Eosinophilic esophagitis (EoE)... 33
Gastroesophageal reflux disease... 37
Drug reaction... 38
Allergy... 38
Photodynamic therapy... 39
Systemic collagen vascular disorders (scleroderma)... 40
Parakeratotic Pattern... 40
Gastroesophageal reflux disease... 41
Candida... 42
Leukoplakia pattern/epidermoid metaplasia... 44
Esophagitis dissecans superficialis/sloughing esophagitis... 46
Esophageal Lymphocytosis Pattern... 49
Gastroesophageal reflux disease... 50
Crohn disease... 50
Contact mucositis... 52
Candida... 52
Common variable immunodeficiency... 52
Dysmotility disorders... 53
Lichen planus/“lichenoid” pattern... 53
Graft-versus-host disease... 56
Pigments... 59
Near Misses... 59
Gastric inlet patch/heterotopic gastric mucosa... 59
Pancreatic heterotopia/metaplasia... 60
Glycogenic acanthosis... 62
Squamous papilloma... 65
Multilayered epithelium... 67
Amyloid... 68
Granular cell tumor... 69
Granulomata... 71
Apoptotic body prominence... 72
Ring mitoses (taxol and colchicine)... 73
Malignancy... 74
Appendix... 74
1% Alcian blue, pH 2. 5 Recipe... 74
PAS/AB pH 2. 5 Recipe... 74
2 STOMACH... 81
The Unremarkable Stomach... 82
Layers... 82
Histology and function... 83
Reactive Gastropathy Pattern... 87Acute Gastritis Pattern... 92
Medications... 92
Infections... 94
Focally enhanced gastritis... 106
Chronic Gastritis Pattern... 108
Autoimmune metaplastic atrophic gastritis... 108
Environmental metaplastic atrophic gastritis... 112
A patterns-based approach to chronic gastritis... 112
Lymphocytic Gastritis Pattern... 122
Collagenous Gastritis Pattern... 128
Gastric Eosinophilia Pattern... 130
Idiopathic eosinophilic gastritis... 132
Medications... 132
Parasitic infection... 134
Inflammatory bowel disease... 134
Connective tissue disorder and vasculitis... 135
Neoplasia... 135
Hyperplasia Pattern... 136
Oxyntic gland hyperplasia... 137
Foveolar hyperplasia... 143
Granulomatous Gastritis Pattern... 148
Vascular and Hemorrhagic Changes Pattern... 151
Portal hypertensive gastropathy... 152
Gastric antral vascular ectasia... 153
Doxycycline-induced injury... 155
Amyloid... 156
Radiation gastritis pattern... 156
Pigments and Extras... 158
Iron... 158
Gastric pseudomelanosis... 161
Calcinosis... 162
Resins... 164
90
Yttrium-labeled microspheres... 164
Near Misses... 166
Amyloidosis... 166
Apoptotic body prominence... 167
Poorly differentiated adenocarcinoma with signet ring cell features... 167
Russell body gastritis... 169
Mucous neck cells... 170
Sarcina... 170
Bezoar and other foreign material... 171
Mast cell disease... 172
3 SMALL BOWEL... 185
The Unremarkable Small Bowel... 186
Acute Duodenitis Pattern... 195
Peptic injury... 196
Infection... 197
Inflammatory bowel disease... 199
Immunoglobulin A (IgA) vasculitis... 200
Acute Ileitis Pattern... 201
Medications... 202
Inflammatory bowel disease... 203
Chronic Inflammation Pattern... 207
Crypt Architectural Disturbance Pattern... 209
Inflammatory bowel disease... 210
Diaphragm disease... 212Graft-versus-host disease... 219
Medications... 222
Allograft rejection, small bowel... 223
Radiation enteritis... 226
Pouchitis and pouch-related changes... 227
Eosinophilia Pattern... 234
Malabsorption Pattern... 236
Overview of malabsorption patterns... 236
Medications... 238
Reactive duodenopathy... 239
Small intestinal bacterial overgrowth... 241
Gluten-sensitive enteropathy (celiac disease)... 244
Nongluten protein sensitivity... 252
Tropical sprue... 253
Common variable immunodeficiency... 255
Inflammatory bowel disease... 256
Autoimmune enteropathy... 257
Collagenous enteritis... 259
Foamy Macrophage Pattern... 261
Mycobacterium avium complex... 262
Whipple disease... 264
Nonspecific scattered macrophages... 269
Dilated Lacteal Pattern... 270
Primary lymphangiectasia... 270
Secondary lymphangiectasia... 271
Metaplasia and Heterotopia... 274
Reactive duodenopathy... 274
Gastric heterotopia... 276
Pancreatic heterotopia... 277
Pyloric metaplasia... 278
Pigments and Extras... 280
Titanium (“peyer patch pigment”)... 281
Tattoo pigment... 282
Pseudomelanosis duodeni... 283
Formalin pigment (acid formaldehyde hematin)... 285
Melanoma... 286
90
Yttrium-labeled microspheres... 287
Near Misses... 290
Sneaky adenocarcinoma... 290
Isospora... 291
Giardia duodenalis (giardia lamblia or giardia intestinalis)... 294
Common variable immunodeficiency... 295
Collagenous enteritis... 296
Sneaky neuroendocrine tumor... 297
4 COLON... 309
The U

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