Signal Transduction

Key Features


In-depth insight into a subject central to cell biology and fundamental to biomedicine, including drug development


Extensive conceptual colour artwork to assist with comprehension of key topics


Special emphasis on the integration of how molecular (domain) structure determines protein function


Comprehensive referencing of both core and historical literature


Guided access and inclusion of Protein Data Bank and Swiss-Prot accession codes and URLs


Readership
Established researchers as well as advanced undergraduate and graduate researchers, and scientists working in cell biology, pharmacology, immunology, and related fields.

Contents


Chapter 1 Prologue: Signal Transduction, origins and ancestors

Chapter 2 First messengers

Chapter 3 Receptors

Chapter 4 GTP-binding proteins and signal transduction

Chapter 5 Effector enzymes coupled to GTP binding proteins: adenylyl cyclase and phospholipase C

Chapter 6 The regulation of visual transduction and olfaction

Chapter 7 Intracellular calcium

Chapter 8 Calcium effectors

Chapter 9 Phosphorylation and dephosphorylation: protein kinases A and C

Chapter 10 Nuclear receptors

Chapter 11 Growth Factors: setting the framework

Chapter 12 Signalling pathways operated by receptor protein tyrosine kinases

Chapter 13 Signal transduction to and from adhesion molecules

Chapter 14 Adhesion molecules in the regulation of cell differentiation: Mainly about Wnt

Chapter 15 Activation of the innate immune system: the Toll-like receptor 4 and Signalling through Ubiquitylation

Chapter 16 Traffic of white blood cells

Chapter 17 Tyrosine protein kinases and adaptive immunity : TCR, BCR, soluble tyrosine kinases and NFAT

Chapter 18 Phosphoinositide 3 kinases, protein kinase B and signalling through the insulin receptor

Chapter 19 Protein Kinase C revisited

Chapter 20 Signalling through receptor serine/threonine kinases

Chapter 21 Protein dephosphorylation and protein phosphorylation

Chapter 22 Notch

Chapter 23 Targeting transduction pathways for research and medical intervention

Chapter 24 Protein domains and signal transduction

Author Information
By Bastien D. Gomperts, University College, London, UK; Ijsbrand M. Kramer, University of Bordeaux, Talence, France and Peter E.R. Tatham, University College, London, UK