Sarcoidosis

Sarcoidosis represents a major challenge for physicians - not just in respiratory medicine, but across a range of specialties. This book, with a multi-disciplinary authorship of the highest standard, presents the most up to date thinking on all aspects of the condition, from epidemiology to clinical manifestations and treatment options. Full coverage is given to both respiratory and non-respiratory aspects; the basic science that underlies the disease and its progression is evaluated in detail, and placed into its correct clinical context. Possible future advances are covered in a concluding section.

The editors - all leading figures in the field with international reputations - have compiled the definitive work on the subject in a single volume. The book is fully comprehensive and evidence-based and will be an essential addition to the bookshelves of all whose practice involves the care and treatment of patients with sarcoidosis.

The definitive work on the subject: evidence-based and comprehensive
Edited by leading figures from the UK and US, with an international chapter authorship
Considers all aspects of the condition - from epidemiology through diagnosis to treatment options and possible future advances
Generously illustrated throughout


Table of Contents:
Section 1
Historical Survey, definition, epidemiology
Historical survey
Definition
Epidemiology
[including prevalence, incidence and
modes of presentation]
Section 2
Aetiology, Pathology, Immunology and Genetics
Aetiology
Pathology
[including ultrastructure and lavage]
Immunology
Genetics
Section 3
Investigations
The radiology of the lungs and the pleura
Intervention and radiological procedures
[including PET and ultrasound]
Lung function
[including fitness to fly, blood gases)
Endoscopy
Lavage
DEXA scanning
[including untreated inactive, active and resurgant sarcoidosis]
Nuclear medicine imaging
ECG; Holter monitoring; exercise tests
Tuberculin skin tests and ELISPOT
The Kveim reaction – in vivo and in vitro
Serology; serum ACE, proteins, liver function tests, serum calcium and 24 hour urinary calcium excretion, etc
Sleep studies
Section 4
The heart
Upper respiratory tract
Asthma/irritable airways
Pulmonary fibrosis
The heart, pericardium, large and small vessels
Pulmonary hypertension
Echo
MRI
Thallium/gallium studies
The upper respiratory tract
Asthma/irritable airways
Pulmonary fibrosis
Section 5
Liver and GI tract
Spleen, blood and bone marrow
The nervous system
Renal and calcium metabolism
Psychiatric aspects
The liver and gastrointestinal tract
The spleen, blood and bone marrow
The nervous system
CSF
MRI
The kidneys and calcium metabolism
[including renal transplantation and gastrourinary tract]
Psychiatric aspects
Section 6
The skin
Ocular changes
Bones joints and skeletal muscles
Superficial lymphadenopathy
The endocrine glands
Sarcoidosis of the skin
Ocular changes
Neuro-ophthalmology
Bones, joints and skeletal muscles
[including radiology]
Peripheral muscles
Superficial lymphadenopathy
The endocrine glands
Section 7
Beryllium disease
Sarcoidosis/HIV and AIDS
Sarcoid; relationships to neoplasm
Chapter 29
Sarcoid/HIV and AIDS
Sarcoid/relationship to neoplasm/chemotherapy [including isolated breast lesions]
Sarcoid/antibody deficiency syndromes
Concomitant or associated disorders
Infections with agents causing granulomatous inflammation – mycobacteria, aspergillosis, nocardiasis, toxoplasma, herpes simplex, etc.
Miscellaneous associated disorders including Sjogren’s syndrome, gamma globulin deficiency, SLE, polyarteritis nodosa, amyloidosis, bronchiectasis, Crohn’s, UC, etc.
Section 8
Childhood sarcoid
Pulmonary and extrapulmonary involvement by sarcoidosis in childhood
Section 9
Diagnosis and treatment of sarcoidosis
Diagnosis of sarcoidosis: history, physical examination, presumptive diagnosis without biopsy, sources of biopsy material, utilisation of investigations and imaging
Treatment of sarcoidosis:
Philosophical considerations
Surveillance aspects
Treatment; first and second line drugs
Recently introduced modes of suppressive therapy
Section 10
Surgical investigations and management
Pulmonary/cardiac transplantation
Physiotherapy
Rehabilitation
Immunisation/vaccination and advice
Surgical investigation and management
Pulmonary/cardiac transplantation
Physiotherapy in sarcoidosis
Rehabilitation
[including fatigue, pain, exercise intolerance, diaphragmatic function, granulomatous infiltration]
Quality of life and long-term oxygen therapy
Immunisation/vaccination
[including BCG, multiviral protection, flu vaccine, etc]
Section 11
Future considerations
Future progress in investigations and management

About the Author(s):

Donald N Mitchell MD FRCP

Hon Consultant Physician

Royal Brompton and University College Hospitals

London, UK

David R Moller MD

Professor of Medicine and Director

Sarcoidosis Clinic and Research Program

Department of Medicine

The Johns Hopkins University School of Medicine

Baltimore, Maryland, USA

Stephen G Spiro BSc MD FRCP

Professor of Respiratory Medicine and Honorary Consultant Physician

University College London and The Royal Brompton Hospital

London, UK

Athol Wells MBChB MD FRACP FRCP FRCR

Professor of Respiratory Medicine and Head of Interstitial Lung Disease Unit

The Royal Brompton Hospital

London, UK