Prostate Cancer: Signaling Networks, Genetics, and New Treatment Strategies

Award winning authors present a comprehensive review of new perspectives in prostate cancer research and open up new directions in the clinical management of prostate cancer. In, "Prostate Cancer: Signaling Networks, Genetics, and New Treatment Strategies", the authors focus on the biology, genetics, molecular signaling networks in the disease process, and recent advances in the treatment of prostate cancer. This state-of-the-art title provides key insights into cutting edge advances in prostate cancer research, such as laparoscopic radical prostatectomy, and offers a critical evaluation and discussion of opportunities for development of novel therapies for prostate cancer. Clinical trials that have not been covered or evaluated in any other books currently available are also discussed. Invaluable to physicians and researchers, "Prostate Cancer: Signaling Networks, Genetics, and New Treatment Strategies" provides a comprehensive translational resource as well as an important source of information for prostate cancer patients.

Table of contents
1. Histopathology and Molecular Biology of Prostate Atrophy: A Lesion Associated with Inflammation, PIN, and Prostate Cancer

2. Epigenetic Gene Silencing in Prostate Cancer

3. Inherited Genetic Changes in Prostate Cancer

4. Prostate Molecular Oncogenesis: Gene Deletions and Somatic Mutations

5. Somatic Genetic Changes in Prostate Cancer: Androgen Receptor Alterations

6. Androgen Receptor in Prostate Cancer Progression

7. Epigenetic Modification and Acetylation of Androgen Receptor Regulate Prostate Cellular Growth


8. Estrogen Receptor Alpha and Beta in the Regulation of Normal and Malignant Prostate Epithelium

9. Estrogen Action in Normal Prostate Epithelium and in Prostate Cancer

10. Hypoxia Inducible Factor 1 and Angiogenesis in Prostate Cancer

11. Signal Transduction by the Ras – MAP Kinase Pathway in Prostate Cancer Progression

12. Transcription Factors Stat5 and Stat3: Survival Factors for Prostate Cancer Cells

13. Role of PI3K-Akt and PTEN in the Growth and Progression of Prostate Cancer

14. New Perspectives in Prediction of Clinical Outcome of Prostate Cancer: TMPRSS2-ETS Gene Fusion in Prostate Cancer

15. New Directions in Radiation Therapy of Prostate Cancer: Brachytherapy and Intensity Modulated Radiation Therapy

16. Advances in Surgical Intervention of Prostate Cancer: Comparison of the Benefits and Pitfalls of Retropubic, Perineal and Laparoscopic Radical Prostatectomy

17. Targeted Therapy Trials for Prostate Cancer

18. New Perspectives on Chemotherapy of Prostate Cancer

19. Concluding Remarks: The Future of Prostate Cancer
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Pestell, Richard G.
Nevalainen, Marja T.