Platelets

First edition won Best Book in Medical Science Award from the Association of American Publishers
Contains fourteen new chapters on topics such as platelet genomics and proteomics, inhibition of platelet function by the endothelium, clinical tests of platelet function, real time in vivo imaging of platelets, and inherited thrombocytopenias
A comprehensive full color reference comprising over 70 chapters, 1400 pages, and 16,000 references

Related Titles

Manual of Pediatric Hematology and Oncology, 4th Edition
The Blood Group Antigen FactsBook, 2nd Edition

Related Links and Downloads

Author web site - Author web site



Description
PLATELETS is the definitive current source of state-of-the-art knowledge about platelets and covers the entire field of platelet biology, pathophysiology, and clinical medicine. Recently there has been a rapid expansion of knowledge in both basic biology and the clinical approach to platelet-related diseases including thrombosis and hemorrhage. Novel platelet function tests, drugs, blood bank storage methods, and gene therapies have been incorporated into patient care or are in development. This book draws all this information into a single, comprehensive and authoritative resource.



Readership
Hematologists, cardiologists, blood bankers, stroke physicians, pathologists, researchers in thrombosis and hemostasis, and students and fellows working in these fields

Quotes
"This is the second edition of a comprehensive book on everything you could ever possibly want to know about platelets...The purpose is to provide a comprehensive, definitive, and authoritative book on platelets. These are worthy objectives, well met in this updated edition...This book would interest anyone wanting to learn about platelets: physicians at all stages of training or practice, clinical laboratory scientists at any stage of training or practice, and basic scientists interested in learning about clinical aspects of platelets...This is the book I'll use whenever I have to answer any type of platelet question. If you field platelet questions, you should get this book, too." - Valerie L. Ng, PhD, MD, Alameda County Medical Center/Highland Hospital, FOR DOODY'S (4 Stars) "...the book is a clearly written, concise, and comprehensive discussion of platelets and their disorders that will be useful to anyone whose professional activity involves these important little cells." -Michael J. Domanski, MD, National Heart Lung and Blood Institute, in JAMA "This is a fantastic resource for anyone who treats patients with platelets disorders or is engaged in platelet or megakaryocyte-based research." - BRITISH JOURNAL OF HAEMATOLOGY

Contents
Foreword A Brief History of Ideas About Platelets in Health and Disease. Barry S. Coller Part One: Platelet Biology 1. The Evolution of Mammalian Platelets. Jack Levin 2. Megakaryocyte Development and Platelet Formation. Joseph E. Italiano, Jr., John H. Hartwig 3. Platelet Structure. James G. White 4. The Platelet Cytoskeleton. John H. Hartwig 5. Platelet Genomics and Proteomics. Ángel García, Yotis Senis, Michael G. Tomlinson, Steve P. Watson 6. Platelet Receptors. Kenneth J. Clemetson, Jeannine M. Clemetson 7. The Glycoprotein Ib-IX-V Complex. Robert K. Andrews, Michael C. Berndt, José A. López 8. Integrin αIIbβ3. Edward F. Plow, Michelle Pesho, Yan-Qing Ma 9. Thrombin Receptors. Wadie F. Bahou 10. The Platelet P2 Receptors. Marco Cattaneo 11. PECAM-1. Melanie S. Novinska, Vipul Rathore, Debra K. Newman, Peter J. Newman 12. P-Selectin/PSGL-1 and Other Interactions Between Platelets, Leukocytes, and Endothelium. Rodger P. McEver 13. Inhibition of Platelet Function by the Endothelium. Sybille Rex, Jane E. Freedman 14. Platelet Polymorphisms. Vahid Afshar-Kharghan, K. Vinod Vijayan, Paul F. Bray 15. Platelet Secretion. Guy L. Reed 16. Signal Transduction During the Platelet Plug Formation. Lawrence F. Brass, Timothy J. Stalker, Li Zhu, Donna S. Woulfe 17. Outside-in Signaling By Integrin αIIbβ3. Nicolas Prévost, Sanford J. Shattil 18. Platelet Thrombus Formation in Flowing Blood. Brian Savage, Zaverio M. Ruggeri 19. Interactions Between Platelets and the Coagulation System. Beth A. Bouchard, Saulius Butenas, Kenneth G. Mann, Paula B. Tracy 20. Platelet-Derived Microparticles. Rienk Nieuwland, Augueste Sturk 21. The Role of Platelets in Fibrinolysis. Bradley A. Maron, Joseph Loscalzo 22. Platelet Function in the Newborn. Sara J. Israels Part Two: Tests of Platelet Function 23. Clinical Tests of Platelet Function. Paul Harrison, David Keeling 24. Platelet Counting. Carol Briggs, Paul Harrison, Samuel J. Machin 25. The Bleeding Time. Stuart E. Lind, Carla D. Kurkjian 26. Platelet Aggregation. Lisa K. Jennings, Melanie McCabe White 27. The VerifyNow System. Steven R. Steinhubl 28. Platelet Function Analyzer (PFA)-100. John L. Francis 29. Impact Cone and Plate(let) Analyzer. David Varon, Naphtali Savion 30. Flow Cytometry. Alan D. Michelson, Matthew D. Linden, Marc R. Barnard, Mark. I. Furman, A.L. Frelinger III 31. Thromboxane Generation. Tilo Grosser, Susanne Fries, Garret A. FitzGerald 32. Perfusion Chambers. Philip G. de Groot, Jan J. Sixma 33. Animal Models. David H. Lee, Morris A. Blajchman 34. Real Time In Vivo Imaging of Platelets During Thrombus Formation. Christophe Dubois, Ben Atkinson, Barbara Furie, Bruce Furie Part Three: The Role of Platelets in Disease 35. Atherothrombosis and Coronary Artery Disease. Pascal J. Goldschmidt, Neuza Lopes, Lawrence E. Crawford, Richard C. Becker 36. Central Nervous System Ischemia. Gregory J. del Zoppo 37. Peripheral Vascular Disease. Michael Sobel 38. Diabetes Mellitus. Bernd Stratmann, Barbara Menart, Diethelm Tschoepe 39. Inflammation. Wolfgang Bergmeier, Denisa D. Wagner 40. Antimicrobial Host Defense. Michael R. Yeaman, Arnold S. Bayer 41. Angiogenesis. Alexander Brill, David Varon 42. Tumor Growth and Metastasis. Mary Lynn Nierodzik, Simon Karpatkin 43. Alzheimer’s Disease. Qiao-Xin Li, Colin L. Masters 44. Psychiatric Disorders. George N. M. Gurguis Part Four: Disorders of Platelet Number and Function 45. The Clinical Approach to Disorders of Platelet Number and Function. Alan D. Michelson 46. Immune Thrombocytopenic Purpura. James B. Bussel 47. HIV-1-related Thrombocytopenia. Michael A. Nardi, Zongdong Li, Simon Karpatkin 48. Heparin-induced Thrombocytopenia. Beng H. Chong 49. Drug-induced Thrombocytopenia. Richard H. Aster 50. Thrombotic Thrombocytopenic Purpura and the Hemolytic-Uremic Syndrome. Joel L. Moake 51. Thrombocytopenia in Pregnancy. Keith R. McCrae 52. Thrombocytopenia in the Newborn. Irene A. G. Roberts, Neil A. Murray 53. Alloimmune Thrombocytopenia. Cecile Kaplan, John Freedman 54. Inherited Thrombocytopenias. Michele P. Lambert, Mortimer Poncz 55. Pseudothrombocytopenia. Nicola Bizzaro 56. Thrombocytosis and Essential Thrombocythemia. Ayalew Tefferi 57. Inherited Disorders of Platelet Function. Alan T. Nurden, Paquita Nurden 58. Acquired Disorders of Platelet Function. A. Koneti Rao 59. Cardiopulmonary Bypass. Brian Richard Smith, Henry M. Rinder, Christine S. Rinder Part Five: Pharmacology: Antiplatelet Therapy 60. Aspirin. Eric H. Awtry, Joseph Loscalzo 61. ADP Receptor Antagonists. Marco Cattaneo 62. αIIbβ3 (GPIIb-IIIa) Antagonists. Ramtin Agah, Edward F. Plow, Eric J. Topol 63. Dipyridamole. Wolfgang G. Eisert 64. Cilostazol. Yasuo Ikeda, Toshiki Sudo, Yukio Kimura 65. Experimental Antiplatelet Therapy. Anthony A. Bavry, Deepak L. Bhatt, Eric J. Topol Part Six: Pharmacology: Therapy to Increase Platelet Numbers and/or Function 66. Platelet Growth Factors. David J. Kuter 67. Desmopressin (DDAVP). Pier Mannuccio Mannucci, Marco Cattaneo 68. Factor VIIa. Man-Chiu Poon Part Seven: Platelet Transfusion Medicine 69. Platelet Storage and Transfusion. Peter L. Perrotta, Edward L. Snyder 70. Platelet Substitutes and Novel Methods of Platelet Preservation. David H. Lee, Morris A. Blajchman Part Eight: Gene Therapy for Platelet Disorders 71. Gene Therapy for Platelet Disorders. David A. Wilcox, Gilbert C. White II.


Author Information
By Alan D. Michelson, University of Massachusetts Medical School, Worcester, U.S.A.