Pediatric Bone: Biology & Diseases

Pediatric Bone is the first book to be published to deal exclusively with the biology and diseases of bone as they affect children. Rapid advances have been made in our understanding of the mechanisms and factors controlling the growth and development of bone, and these are discussed in detail in this book. Further, the various diseases of bone which are peculiar to children are highlighted and discussed in the light of our current knowledge with regard to the causation, clinical signs and treatment. The book is aimed to provide those clinicians interested in children's diseases and basic scientists with a comprehensive resource covering the various aspects of bone health and disease in children.


Edited by Francis H. Glorieux, MD, PhD, Professor of Surgery, Pediatrics and Human Genetics, McGill University; Adjunct Professor of Pediatrics, University of Montreal; Director of Research, Shriners Hospital for Children, Montreal, QC Canada; John M Pettifor, Honorary Professorial Researcher and Clinical Professor, Department of Paediatrics, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa and Harald Juppner, Massachusetts General Hospital, Boston, MA U.S.A


Table of Contents:

1 Bone Cell Biology: Osteoblasts, Osteocytes, Osteoclasts

Lynda F. Bonewald, Katharina Jähn

2 Bone Matrix and Mineralization

Marc D. McKee, William G. Cole

3 Prenatal Bone Development

Fanxin Long

4 Postnatal Bone Growth

Christa Maes, Henry M. Kronenberg

5 Dental Development & Maturation

Jean-Marc Retrouvey

6 Parathyroid Hormone and Calcium Homeostasis

John T. Potts, Thomas J. Gardella

7 Phosphate Homeostasis Regulatory Mechanisms

Clemens Bergwitz

8 Vitamin D Biology

Rene St. Arnaud, Marie B. Demay

9 Peak Bone Mass and Its Regulation

Jean-Philippe Bonjour

10 Pregnancy and Lactation

Ann Prentice

11 Fetal Mineral Homeostasis

Christopher S. Kovacs

12 Radiology

Judith Adams

13 Noninvasisve Techniques for Bone Mass Measurement

Mary B. Leonard, Laura K. Bachrach

14 Assessment of Skeletal Maturity

David D. Martin, Noel Cameron

15 Biochemical Markers of Bone Metabolism

Nick Shaw, Wolfgang Högler

16 Pediatric Bone Histomorphometry

Frank Rauch

17 A Diagnostic Approach to Skeletal Dysplasias

Sheila Unger, Andrea Superti-Furga, David L. Rimoin

18 The Spectrum of Pediatric Osteoporosis

Maria Luisa Bianchi, Francis H. Glorieux

19 Osteogenesis Imperfecta

Francis H. Glorieux, David Rowe

20 Sclerosing Bone Dysplasias

Bram Perdu, Geert Mortier, Filip Vanhoenacker, Wim Van Hul

21 Parathyroid Disorders

Harald Juppner, Murat Bastepe, Rajesh Thakker

22 Fibrous Dysplasia

Paolo Bianco

23 Nutritional Rickets

John M. Pettifor

24 Metabolic Bone Disease in the Neonatal Period and its Later Sequelae

Nick Bishop, Mary Fewtrell, Nick Harvey

25 Hereditary Abnormalities of Vitamin D Synthesis or Action

Anthony Portale

26 Familial Hypophosphatemia and Related Disorders

INGRID A. HOLM, MICHAEL J. ECONS, and THOMAS O. CARPENTER

27 Rickets Due to Tubular Abnormalities

Israel Zelikovic and Daniella Magan

28 Hypophosphatasia

Michael Whyte

29 CHRONIC KIDNEY DISEASE MINERAL AND BONE DISORDER

Isidro B. Salusky, Katherine Wesseling Perry

30 Extraskeletal Bone Formation

Eileen M. Shore, Frederick S. Kaplan