Paul's Fundamental Immunology

The textbook that has defined the field of immunology since 1984 is now in its thoroughly revised and updated Sixth Edition. This comprehensive, up-to-date text will be of interest to graduate students,post-doctoral fellows, basic and clinical immunologists, microbiologists and infectious disease physicians, and any physician treating diseases in which immunologic mechanisms play a role. This edition features expanded coverage of regulatory T cells, innate immunity, and dendritic cells. Additional chapters on cytokines are also included. A companion Website offers the fully searchable text, plus all illustrations in full color and comprehensive lists of references. Table Of Contents INTRODUCTION: The Immune System, William Paul ORGANIZATION AND EVOLUTION OF THE IMMUNE SYSTEM: Lymphoid Tissues & Organs, Eitan Akirav, Shan Liao, and Nancy Ruddle / Evolution of the Immune System, Martin Flajnik IMMUNOGLOBULINS AND B LYMPHOCYTES: Immunoglobulins: Structure & Function, Harry W. Schroeder, Jr., David Wald, and Neil S. Greenspan / Antigen Antibody Interactions and Monoclonal Antibodies, Jay A. Berzofsky, Ira J. Berkower, and Suzanne L. Epstein / Immunoglobulins: Molecular Genetics, Edward Max / B Lymphocyte Development, Richard R. Hardy / B Lymphocyte Signaling Mechanisms and Activation, Anthony L. DeFranco / B Lymphocyte Biology, Michael McHeyzer-Williams T LYMPHOCYTES: T Cell Antigen Receptors, Mark M. Davis and Yueh-Hsiu Chen / T Lymphocyte Signaling Mechanisms and Activation, Gary A. Koretzky / Development of T Cells, Ellen Rothenberg and Mary A. Yui / Peripheral T Lymphocyte Responses and Function, Steven L. Reiner THE INTERSECTION OF INNATE AND ADAPTIVE IMMUNITY: Innate Immunity, Ruslan Medzhitov / Dendritic Cells, Muriel Moser / Natural Killer Cells, Wayne Yokoyama / NK T Cells and Other Innate-Like T and B Lineages, Albert Bendelac / Macrophages and Phagocytosis, Siamon Gordon / Major Histocompatibility Complex (MHC) Molecules: Structure, Function, and Genetics, David Margulies, Kannan Natarajan, Jamie Rossjohn, and Jim McCluskey / Cell Biology of Processing and Presentation, Lélia Delamarre and Ira Mellman REGULATION AND EFFECTOR FUNCTIONS OF THE IMMUNE RESPONSE: Immunogenicity and Antigen Structure, Jay Berzofsky and Ira J. Berkower / Fc Receptors and Their Role in Immune Regulation and Inflammation, Jeffrey V. Ravetch and Falk Nimmerjahn / Type I Cytokines and Interferons and Their Receptors, Warren J. Leonard / Interleukin-1 Family of Ligands and Receptors, Charles A. Dinarello / TNF-related Cytokines in Immunity, Carl F. Ware / Chemokines, Philip M. Murphy / Programmed Cell Death, Nicolas Bidère, Helen C. Su, and Michael J. Lenardo / Immunologic Memory, Stephen Schoenberger / Immunological Tolerance, Ronald H. Schwartz / Regulatory/Suppressor T Cells, Ethan M. Shevach / The Mucosal Immune System, Hiroshi Kiyono, Jun Kunisawa, Jerry R. McGhee, and Jiri Mestecky / Neural Immune Interactions, Jeanette I. Webster Marketon and Esther Sternberg / Complement, Cornelia Speth, Wolfgang M. Prodinger, Reinhard Würzner, Heribert Stoiber, and Manfred P. Dierich / Cytotoxic T Lymphocytes, R. Chris Bleackley IMMUNITY TO INFECTIOUS AGENTS: The Immune Response to Parasites, David Sacks, Alan Sher, Eleanor M. Riley, and Tom Wynn / Immunity to Viruses, Hildegund C. J. Ertl / Immune Responses to Intracellular Bacteria, Eric Pamer / Immunity to Extracellular Bacteria, Jeffey N. Weiser and Moon Nahm / Immunology of HIV Infection, Norman L. Letvin / Vaccines, G.J.V. Nossal IMMUNOLOGIC MECHANISMS IN DISEASE: Systemic Autoimmunity, Betty Diamond / Organ-Specific Autoimmunity, Matthais G. von Herrath and Dirk Homann / Immunological Mechanisms of Allergic Disorders, Marsha Wills-Karp / Transplantation Immunology, Megan Sykes, Kathryn Wood, and David H. Sachs / Tumor Immunology, Nicholas P. Restifo, Paul F. Robbins, and Steven A. Rosenberg / Primary Immunodeficiency Diseases, Rebecca Buckley.