Osteoporosis and the Osteoporosis of Rheumatic Diseases

Get new insights into the causes, detection and therapy of osteoporosis and the osteoporosis of rheumatic diseases. In this state-of-the-art resource, you’ll find coverage of all the latest scientific and clinical developments, new concepts in epidemiology, cutting-edge information on genetics and pathogenic mechanisms, current developments in diagnostic interventions and prevention, and the very latest techniques in treatment. This is a must-have reference for comprehensive, one-stop coverage of Osteoporosis.

Reviews
Title: Osteoporosis and the osteoporosis of the rheumatic diseases. A companion to Rheumatology. Editor: Nancy E. Lane and Philip N. Sambrook This excellent book is part of a series of new titles intended as a companion to the 3rd edition of Rheumatology (Mosby). It aims to provide the reader with a state of the art and comprehensive text on osteoporosis. The editors most certainly have fulfilled this mission. Both the editors and most of the authors from the different chapters are recognized as experts in the field. The book covers most if not all areas of osteoporosis and in addition focuses specifically on bone disorders in rheumatic diseases. Importantly, a strong basic science background is provided for most of the issues covered. Nevertheless, the different chapters are pleasant to read and indicate clinically relevant areas conveying essential information that can be used in clinical practice. In this way, many chapters link bench to bedside in a very comprehensive way. The different sections of this book deal with epidemiology, pathogenetic mechanisms, clinical aspects and treatment. A separate section specifically deals with secondary osteoporosis and osteoporosis in the rheumatic diseases. In the first part, the chapters on epidemiology of fractures and on genetics of osteoporosis provide the reader with an up to date state of the art that is rarely found elsewhere. Interesting new points of view and recent developments are brought forward in specific chapters on the principles of bone mechanics and the use of MRI for imaging bone structure and osteoporosis. The treatment section contains exciting chapters in particular on anabolic factors and combination treatments. Finally, a few interesting topics such as transplantation and inflammatory bone loss get a lot of attention in chapters building on both scientifically and clinically relevant data. In general, this book can be an important tool for the rheumatologist to get an up to date review of osteoporosis with ample basic science and clinically relevant information. Rik Lories, MD PhD Laboratory for Skeletal Development and Joint Disorders Division of Rheumatology Department of Musculoskeletal Sciences

Key Features

Allows planning of early interventions, as appropriate, to augment peak adult bone mass.
Highlights the necessary tools for early diagnosis, and monitoring of disease progression.
Discusses the very latest in pharmacologic interventions, including biophosphonates, SERMS, and osteoanabolic agents.
Provides access to the latest information on disease modifying or disease controlling biologic agents.
Incorporates the latest on glucocorticoid and transplantation- induced osteoporosis, as well as osteoporosis in the rheumatic diseases.

Contents
A. Epidemiology
1. Epidemiology of Osteoporosis (women, men, children) 2. Genetics of Osteoporosis 3. Peak Bone Mass Acquisition 4. Who Should we Treat for Osteoporosis?
B. Pathogenetic Mechanisms
1. The Pathogenesis of Osteoporosis- A Disease of Bone Remodeling 2. Biomechanics of Bone 3. Animal Models and Implications for Therapy 4. The Bone Biopsy- What Information Can We Obtain
C. Clinical Aspects of the Disease
1. The Patient with Osteoporosis 2. Clinical Application of the Measurement of Bone Mass a. DXA b. QCT c. Peripheral measurements (pDXA, ultrasound) d. MRI 3. Bone Turnover Markers a. Their Place in the Investigation of Osteoporosis b. The Evaluation of Bone Turnover Markers for Fracture Risk and Treatment 4. The Evaluation of the Patient for Osteoporosis- Using the Diagnostic Tests for Treatment Interventions.
D. Treatment of the Disease (

All chapters cover both the science and the therapy in the prevention and treatment of osteoporosis)
1. Exercise in the Prevention of Osteoporotic Fractures 2. Calcium in the Prevention and Treatment of Osteoporosis 3. Vitamin D and its Metabolites in the Prevention and Treatment of Osteoporosis 4. Statins 5. Estrogen/SERMs- The Science and the Therapy in Prevention and Treatment of Osteoporosis 6. Androgens, Gonadal Steroids in Bone Health 7. Calcitonin: The Science and Clinical Utilization 8. Bisphosphonates: The Science and the Therapy in the Prevention and Treatment of Osteoporosis 9. PTH: The Science and the Therapy in the Treatment of Osteoporosis 10. Combination therapy for Osteoporosis- What does the Data Show Us
E. Non-medical Treatment of Osteoporosis
1. The Disability Associated with Osteoporosis 2. The Rehabilitation of patients with Osteoporosis and Fractures 3. The Treatment of Osteoporotic Fractures- The Surgical Perspective
F. Glucocorticoid-Induced Osteoporosis
1. The Pathogenesis of Glucocorticoid-Induced Bone Loss 2. The Prevention and Treatment of Glucocorticoid-Induced Bone Loss
G. Transplantation-Induced Osteoporosis
1. The Pathogenesis of Transplant-Induced Bone Loss 2. The Prevention and Treatment of Transplantation Induced Bone Loss
H. Osteoporosis and the Rheumatic Diseases
1. Epidemiology of Osteoporosis in RA, SLE, AS 2. The Pathogenesis of Inflammatory Induced Bone Loss 3. The Prevention and Treatment of Inflammatory Induced Bone Loss-Can it Be Done.


Author Information
By Nancy E. Lane, MD; and Philip Sambrook, MBBS, MD, LLB, FRACP, Florance and Cope Professor of Rheumatology, University of Sydney, Royal North Shore Hospital, St. Leonard's, Sydney, Australia