Nutrition and Metabolism: Underlying Mechanisms and Clinical Consequences

Nutrition and Metabolism: Underlying Mechanisms and Clinical Consequences brings together internationally recognized experts to comprehensively review our current understanding of how nutrition interacts with the genetic substrate as well as environmental-exogenous factors, including physical activity or the lack thereof, to result in insulin resistance and the metabolic syndrome. After presenting the scope of the problem, the first major part of the book is devoted to genetics and pathophysiology, the second part of the book presents the public health perspective of the most prevalent problems associated with nutrition and the metabolic syndrome, whereas the third major part of the book focuses on clinical assessment and management of the main disease states associated with inappropriate nutrition and the metabolic syndrome. Finally, general information useful for both clinicians and researchers alike is presented in the Appendix. Nutrition and Metabolism: Underlying Mechanisms and Clinical Consequences offers the reader an up-to-date and authoritative review of the major scientific and clinical aspects of the overlapping areas between nutrition and metabolism.

Table of contents
Part I Scope of the Problem


1. Nutrition and the metabolic syndrome: a 21st century epidemic of obesity and eating disorders

Christos S. Mantzoros


Part II Genetics and Pathophysiology


2.. Genes and gene-environment interactions in the pathogenesis of obesity and the metabolic syndrome

Despina Sanoudou, Elizabeth Vafiadaki, and Christos S. Mantzoros


3.. Environmental inputs, intake of nutrients and endogenous molecules contributing to the regulation of energy homeostasis

Theodoros Kelesidis, Iosif Kelesidis, and Christos S. Mantzoros


4.. Central integration of environmental and endogenous signals important in the regulation of food intake and energy expenditure

Iosif Kelesidis, Theodoros Kelesidis, and Christos S. Mantzoros


5. Insulin resistance in states of energy excess – underlying pathophysiological concepts

Susann Blüher and Christos S. Mantzoros


Part III Public Health Perspective


6. Targeting childhood obesity through lifestyle modification

Eirini Bathrellou and Mary Yannakoulia


7. Diet and physical activity in the prevention of obesity

Frank B. Hu


8.. Diet and exercise in the prevention and management of the metabolic syndrome

Mary Yannakoulia, Evaggelia Fappa, Janice Jin Hwang and Christos S. Mantzoros


9. Diet and physical activity in cancer prevention

Alicja Wolk


Part IV Nutrition Recommendations


10. Nutrition recommendations for the general population: Where is the science?

Walter C. Willett and Meir J. Stampfer


11. Nutrition recommendations and interventions for subjects with cardiovascular disease

Meropi Kontogianni, Mary Yannakoulia, Lauren Kuhn, Sunali Shah, Kristina Day, and Christos S. Mantzoros


12. Medical Nutrition Therapy in the treatment of type 1 and type 2 diabetes

Olga Kordonouri, Caroline Apovian, Lauren Kuhn, Thomas Danne, and Christos S. Mantzoros


13. Mediterranean diet in dietary patterns: Current perspectives

Jessica Fargnoli, Yoon Kim, and Christos S. Mantzoros


Part V Clinical Assessment and Management


14. Lifestyle and pharmacology approaches for the treatment of hypertension

and hyperlipidemia

J. Peter Oettgen


15. Diagnosis, evaluation and medical management of obesity and diabetes

Jean L. Chan and Christos S. Mantzoros


16. Surgical management of obesity and post-operative care

George L. Blackburn, Torsten Olbers, Benjamin E. Schneider, Vivian M. Sanchez, Aoife Brennan, Christos S. Mantzoros, and Daniel B. Jones


17. Long term impact of weight loss on obesity and obesity associated comorbidities

Janice Jin Hwang, George L. Blackburn and Christos S. Mantzoros


Part VI Appendix

Deanna Olenczuk and Christos S. Mantzoros


18. Methods for classifying, diagnosing, and monitoring obesity


19. Methods for classifying, diagnosing, and monitoring type 2 diabetes


20. Major nutrition recommendations and interventions for subjects with hyperlipidemia, hypertension and/or the diabetes



21. Food Guide Pyramids and the 2005 MyPyramid

Jessica Fargnoli and Christos S. Mantzoros


Part VII Resources


22. Resources.