Movement Disorders

Featuring contributions from more than one hundred leading experts, this full-color text covers pathophysiology, diagnosis, and management of all movement disorders - from ataxia to Parkinson's Disease. Movement Disorders examines the neurobehavioral changes and comorbidities that frequently occur and incorporates the latest genetic information and the most current references.



Chapters cover Clinical Presentation and Course, Pathophysiology, Differential Diagnosis, Etiologies, and Treatment. The third edition is highlighted by a new full-color presentation, more than 240 color illustrations and photos, and a DVD with video clips of patients with movement disorders.


Ray L. Watts, MD
John N. Whitaker Professor and Chairman of Neurology
Director of Clinical Research
Parkinson's Disease and Movement Disorder Research Program
University of Alabama at Birmingham

David G. Standaert, MD, PhD
John and Juanelle Strain Professor of Neurology
Director, Program for Neurodegeneration and Experimental Therapeutics
Director, Movement Disorders Program
Vice-Chair of Neurology
University of Alabama at Birmingham

Jos� A. Obeso, MD, PhD
Consultant and Professor of Neurology
Clinica Universitaria and Medical School
Senior Researcher, Neuroscience, CIMA University of Navarra
Pamplona, Spain



Table of contents

Contributors
Foreword
Preface
SECTION I: INTRODUCTION TO MOVEMENT DISORDERS
1. Overview of Movement Disorders and Approach to the Patient, Zbigniew K. Wszolek and Donald B. Calne
2. Assessing Disability in Movement Disorders: Quantitative Techniques and Rating Scales, Seth L. Pullman and Rachel Saunders-Pullman
3. Neuroimaging of Movement Disorders, David J. Brooks and Nicola Pavese
SECTION II: NEUROSCIENTIFIC FOUNDATIONS
4. Functional Anatomy of the Basal Ganglia, Yoland Smith
5. Pathophysiology of the Basal Ganglia and Movement Disorders, Jos� A. Obeso, Maria c. Rodriguez-Oroz, In�s Trigo-Damas, and M. Rodriguez
6. Functional Neurochemistry of the Basal Ganglia, Anthony P. Nicholas and David G. Standaert
7. Neurotrophic Factors, Mart Saarma, P�ivi Lindholm, and Urmas Arum�e
8. Neuropathology of Parkinsonian Syndrome, Dennis W. Dickson
SECTION III: CLINICAL DISORDERS
I. Parkinsonian States: Parkinson's Disease
9. Genetics of Parkinson's Disease and Parkinsonian Disorders, Andrew B. West
10. Epidemiology of Parkinson's Disease, Connie Marras and Caroline M. Tanner
11. Neurochemistry and Neuropharmacology of Parkinson's Disease, Federico Micheli, Maria G. Cersosimo, and G. Frederick Wooten
12. Etiology of Parkinson's Disease, Yoshikuni Mizuno, Nobutaka Hattori, and Hideki Mochizuki
13. Clinical Manifestations of Parkinson's Disease, Jayne R. Wilkinson, Daniel Weintraub, and Matthew B. Stern
14. Neuroprotective Therapies for Parkinson's Disease, Talene A. Yacoubian and David G. Standaert
15. Pharmacological Treatment of Parkinson's Disease, Werner Poewe and C. P. Mahlkne
16. Restorative Therapies for Parkinson's Disease, Olle Lindvall
17. Stereotaxic Surgery and Deep Brain Stimulation for Parkinson's Disease and Movement Disorders, Milind Deogonkar, Andre Machado, and Jerrold L. Vitek
18. Parkinson's Disease Dementia: Features and Management, Murat Emre, Hasmet A. Hanagasi, and David J. Burn
19. Parkinson's Disease: Neuropathology, John E. Duda
Other Parkinsonian Syndromes
20. Multiple-System Atrophy, Bradley J. Robottom, Lisa M. Shulman, and William J. Weiner
II: Parkinsonian States: Akinetic-Rigid Syndromes
21. Progressive Supranuclear Palsy, Lawrence J. Golbe
22. Corticobasal Degeneration, Natividad P. Stover and Ray L. Watts
23. Infectious, Postinfectious, Toxin-Induced, and Drug-Induced Parkinsonism, Rajesh Pabwa and Kelly E. Lyons
24. Rare Degenerative Syndromes Associated with Parkinsonism, Candan Depboylu, J. Carsten M�ller, and Wolfgang H. Oertel
III. Tremor Disorders
25. Essential Tremor, Kelly E. Lyons
26. Uncommon Forms of Tremor, Shyamal H. Mehta, Kapil D. Sethi, and Bala V. Manyam
27. Pathophysiology of Tremor, Rodger J. Elble
28. Genetics Forms of Dystonia, Susan B. Bressman
29. Adult-Onset Idiopathic Focal Dystonias, Maria J. Marti and Eduardo S. Tolosa
30. Treatment of Dystonia, Octavian R. Adam and Joseph Jankovic
31. Symptomatic Dystonias, J.L. Lopez-Sendon, S. Cantarero, C. Tabernero, A.V. Vazquez, and J.G. de Yebenes
IV: Choreatic Disorders: Huntington's Disease
32. Genetics and Molecular Biology of Huntington's Disease, James F. Gusella, Marcy E. Macdonald, and Vanessa C. Wheeler
33. Clinical Features and Treatment of Huntington's Disease, Sarah Wahlster and Jang-Ho J. Cha
34. Neuropathology and Pathophysiology of Huntington's Disease, Steven M. Hersch, H. Diana Rosas, and Robert J. Ferrante
35. Tardive Dyskinesia, Stacy Horn and Christopher G. Goetz
36. Other Choreatic Disorders, Margery H. Mark
V. Myoclonic Disorders
37. Classification, Clinical Features, and Treatment of Myoclonus, Rafael Gonzalez-Redondo, Asier Gomez, and Jose A. Obeso
38. Pathophysiology of Myoclonic Disorders, Camilo Toro and Mark Hallett
39. Tourette Syndrome and Related Disorders, Jorge L. Juncos
40. The Molecular Genetics of the Ataxias, George R. Wilmot, S.H. Subramony, and Henry L. Paulson
41. Physiology and Pathophysiology of the Cerebellum, and Rehabilitation Strategies After Cerebellar Injury, W. Thomas Thach
VI: Other Movement Disorders
42. Wilson's Disease, Ronald F. Pfeiffer
43. Stiff-Person Syndrome, Oscar S. Gershanik
44. Gait Disorders, Lewis Sudarsky
VIII: Special Considerations
45. Movements Disorders in Childhood, Erika Augustine, Jonathan Mink, and Leon S. Dure
46. Restless Legs Syndrome and Periodic Leg Movement of Sleep, David B. Rye and Lynn Marie Trotti
47. Movement Disorders Specific to Sleep and Sleep in Waking Movement Disorders, Donald L. Bliwise, Lynn Marie Trotti, and David B. Rye
48. Psychogenic Movement Disorders, Daniel S. Sa, Nestor Galvez-Jimenez, and Anthony E. Lang
49. Systemic Illnesses that Cause Movement Disorders, Amy Colcher and Howard I. Hurtig
Index