Hypertension and Hormone Mechanisms

Hypertension, a major risk factor for cardiovascular disease and stroke, is present in approximately one-quarter of the adult population of Western societies. Advances in the study and treatment of this condition are captured in this exceptionally important book. In Hypertension and Hormonal Mechanisms, distinguished panels of leading experts discuss new developments in hormones/autacoids related to hypertension. During the past decade, truly remarkable advances have been made in the identification of new components of the renin-angiotensin system. This book also provides the most up to date advancements in topics such as the importance of diabetes and obesity in hypertension and the new role of calcitonsin gene-related peptide (CGRP) in hypertension. Hypertension and Hormonal Mechanisms, written by the world’s experts in this field, aims to open new doors leading researchers closer to understanding the etiology and pathogenesis of primary (essential) hypertension, and to stimulate active research in the fundamental mechanisms of hypertension so that new therapies, and even prevention, can be realized in the not-too-distant future.

Table of contents
Hypertension and Hormonal Mechanisms

Chapter Outline

(A) New Developments in the Renin-Angiotensin System

1. The Intrarenal Renal-Angiotensin System
Minolfa C. Prieto-Carrasquero, Hiroyuki Kobori and L. Gabriel Navar
Tulane University

2. Cardiac and Vascular Renin-Angiotensin Systems
Rajesh Kumar, Kenneth M. Baker and Jing Pan
Texas A & M University Health System

3. Regulation of Cardiovascular Control Mechanisms by Angiotensin (1-7)
and Angiotensin Converting Enzyme-2
Carlos M. Ferrario, David B. Averill, K. Bridget Brosnihan, Mark C. Chappell, Debra I. Diz, Patriciai E. Gallagher, Liomar A.A. Neves and E. Ann Tallant
Wake Forest University

4. Angiotensin IV and the AT4 Receptor
T. A. Jenkins, F.A.O. Mendelsohn, A.L. Albiston and S.Y. Chai
Howard Florey Institute of Experimental Physiology and Medicine, Melbourne

5. AT2 Receptors in Blood Pressure Regulation
Robert M. Carey and Helmy M. Siragy
University of Virginia Health System

6. Angiotensin II and Inflammation
Rhian M. Touyz and Ernesto L. Schiffrin
Clinical Research Institute of Montreal

7. Aldosterone and Vascular Damage
Hilton V. Joffe, Gordon H. Williams and Gail K. Adler
Harvard Medical School

(B) The Sympatho-Adrenal System in Hypertension

8. Neurogenic Human Hypertension
David Robertson, Andre Diedrich and Italo Biaggioni
Vanderbilt University

9. Calcitonin Gene-Related Peptide and Hypertension
Donald J. DiPette and Scott C. Supowit
Texas A& M University

10. The Renal Dopaminergic System in Hypertension
Pedro A. Jose, Robert M. Carey and Robin A. Felder
Georgetown University and the University of Virginia Health
System

(C) Metabolic Disorders and Hypertension

11. The Insulin Resistance Syndrome and Hypertension
James R. Sowers
University of Missouri

12. Fatty Acids and Hypertension
Brent M. Egan
Medical University of South Carolina

13. Goal-Oriented Hypertension Management in Diabetic and Non-Diabetic
Patients
Gregory M. Singer, John F. Setaro and Henry R. Black
Rush Presbyterian - St. Luke's Medical Cente

(D) Endothelial Hormones and Autacoids and Hypertension

14. Nitric Oxide and Hypertension
David L. Mattson and Allen W. Cowley
Medical College of Wisconsin

15. Role of Endothelin 1 in Hypertension
Ernesto L. Schiffrin
Clinical Research Institute of Montreal

16. The Kallekrein/Kinin System and Hypertension
Julie Chao and Lee Chao
Medical University of South Carolina

(E) Other Hormonal Systems and Hypertension

17. Natriuretic Peptides and Hypertension
Kailesh N. Pandey
Tulane University

18. Sex Steroids and Hypertension
Suzanne Oparil and Andrew Miller
University of Alabama Birmingham

19. The Lipoxygenase System in the Vasculature and Hypertension
Naftali Stern and Michael Tuck
Tel Aviv University and UCLA School of Medicine.