Genomics in Endocrinology: DNA Microarray Analysis in Endocrine Health and Disease

In recent years, the development of new technologies capable of monitoring genome function has resulted in fewer hopeful estimates and increasingly solid depictions of genome output from individual samples. Genomics in Endocrinology focuses on exciting new advances in endocrinology resulting from DNA microarray studies and includes a comprehensive introduction to the use of DNA microarrays in endocrinology. The volume provides the basis for further understanding of the usefulness of microarray analyses in endocrinology research. Topics discussed are the methodology of DNA microarrays and general methods for the analysis of microarray data, as well as studies of a wide variety of normal and abnormal endocrine cells.

In the introductory chapter, the volume’s editors describe several issues in hypothesis formulation, experimental design, data analysis, and follow-up studies that may corroborate, validate, and extend hypotheses gained through microarray analyses. The contributed chapters span a variety of applications that we have divided into the areas of (1) genomic insights into molecular mechanisms responsible for hormone action, (2) genomic characterizations of endocrine producing tissues, and (3) genomic manifestations of diseases of hormonal systems.

A volume on the cutting-edge of technology, Genomics in Endocrinology will provide researchers with an authoritative volume on the most recent advances in monitoring genome function.
Table of contents
Handwerger Table of Contents

introduction

Chapter 1: Microarray-based Gene Expression Analysis of Endocrine
Systems: Principles of Experimental Design and Interpretation
Jegga, Anil G., Bruce J Aronow, Stuart Handwerger

hormone action and molecular mechanisms

Chapter 2: Expression Profiles and Transcription Factors Involved in
Parathyroid Hormone Signaling in Osteoblastic Cells
Gene Ling Qin, Ping Qui, Nicola C. Partridge

Chapter 3: Analysis of Growth Hormone effects on hepatic gene
expression in hypophysectomized rats.
Amilcar Flores-Morales and Leandro Fernandez-Perez

Chapter 4: Gene expression profiling in leiomyoma in response to GnRH
therapy and TGF-b
Nasser Chegini and Xiaoping Luo

Chapter 5: Gene Profiling Analysis of Androgen Receptor Mediated
Function
Comstock, Clay E.S.,Craig J. Burd, Walter J. Jessen, Karen E. Knudsen

Chapter 6: Interrogating Estrogen Receptor Signaling in Breast Cancer
by Chromatin Immunoprecipitation Microarrays
Cheng, Alfred S.L., Huey-Jen Lin, and Tim H.-M. Huang

Chapter 7: Gene expression analysis of adrenal cortex in health and
disease
Anelia Horvath and Constantine A. Stratakis

endocrine producing tissues

Chapter 8: DNA microarray analysis of decidualization
Ori Eyal, MD and Stuart Handwerger, MD

Chapter 9: Large scale DNA Microarray data analysis reveals
glucocorticoid receptor-mediated breast cancer cell survival pathways
Min Zou, Wei Wu, and Suzanne D. Conzen

Chapter 10: Application of Microarrays for gene transcript analysis in
type 2 diabetes
R. Sreekumar, C. P. Kolbert, Y. Asmann, and K.S.Nair

Chapter 11: DNA Microarray Analysis and Effects of TSH, Iodide,
Cytokines and Therapeutic Agents on Gene Expression in Cultured Human
Thyroid Follicles
Kanji Sato, Kazuko Yamazaki, Emiko Yamada


diseases of hormonal systems

Chapter 12: Genomics and Polycystic Ovary Syndrome (PCOS): the Use of
Microarray Analysis to Identify New Candidate Genes
Jennifer R. Wood, PhD and Jerome F. Strauss, III MD, PhD

Chapter 13: Microarray Analysis of Alterations Induced by Obesity in
White Adipose Tissue Gene Expression Profiling
Julien Tirard, Ricardo Moraes, Danielle Naville, and Martine Begeot

Chapter 14: Novel Molecular Signaling and Classification of Human
Clinically Nonfunctioning Pituitary Adenomas Identified by Microarray
and Reverse Transcription-Quantitative Polymerase Chain Reaction
Chheng-Orn Evans, Carlos S. Moreno, Nelson M. Oyesiku

Chapter 15: Gene Expression Studies of Prostate Hyperplasia in
Prolactin Transgenic Mice
Karin Dillner PhD, Jon Kindlom MD, PhD, Amilcar Flores-Morales PhD, and
Hagan Wennbo MD, PhD.