Childhood Leukemias

Childhood leukemias represent nearly one third of all cancers in children and present a unique challenge to oncologists, pediatricians, hematologists, and other health professionals. Dr Ching-Hon Pui has assembled an expert team of authors to develop the most comprehensive, clinically-oriented, and authoritative reference dedicated to these diseases. Childhood Leukemias moves from the laboratory bench to the patient bedside in four easily-accessible sections. Part one presents an historical overview, whilst part two presents an in-depth review of topics needed to understand the pathobiology of leukemia. Part three builds upon this scientific foundation by explaining practical approaches to clinical diagnosis, evaluation, and treatment, and part four outlines major clinical complications which may arise during and after treatment, along with chapters on supportive care, psychosocial issues, and nursing. Fully referenced and up-to-date, Childhood Leukemias is an absolute ‘must-have’ for any physician or investigator who deals with leukemias in childhood.

• Comprehensive text with judicious blend of clinical and biological topics • New chapters on chemoresistance, advances in therapy-related leukemias, antibody-targeted therapy, pain management, genetic predisposition and treatment possibilities in countries with limited resources • Written by leading international experts in the field of childhood leukemias

Contents
Part I. History and General Issues: 1. Historical perspective Donald Pinkel; 2. Diagnosis and classification Mihaela Onciu and Ching-Hon Pui; 3. Epidemiology and etiology Logan Spector, Julie A. Ross, Leslie L. Robison and Smita Bhatia; Part II. Cell Biology and Pathology: 4. Anatomy and physiology of hematopoiesis Connie J. Eaves and Allen C. Eaves; 5. Hematopoietic growth factors James N. Ihle; 6. Signal transduction in the regulation of hematopoiesis James N. Ihle; 7. Immunophenotyping Fred G. Behm; 8. Immunoglobulin and T-cell receptor gene rearrangements Jacques J. M. van Dongen and Anton W. Langerak; 9. Cytogenetics of acute leukemias Susana C. Raimondi; 10. Molecular genetics of acute lymphoblastic leukemia Adolfo Ferrando, Jeffrey E. Rubnitz and A. Thomas Look; 11. Molecular genetics of acute myeloid leukemia Robert Lorsbach and James R. Downing; 12. Apoptosis and chemoresistance Kirsteen H. MacLean and John L. Cleveland; 13. Heritable predispositions to childhood hematologic malignancies Doan Le, Kevin Shannon and Beverly J. Lange; Part III. Evaluation and Treatment: 14. Pharmacokinetics, pharmacodynamics and pharmacogenetic considerations Shinji Kishi, Williams E. Evans and Mary V. Relling; 15. Assays and molecular determinants of cellular drug resistance Monique L. den Boer and Rob Pieters; 16. Acute lymphoblastic leukemia Ching-Hon Pui; 17. Relapsed acute lymphoblastic leukemia Günter Henze and Arend von Stackelberg; 18. B-cell acute lymphoblastic leukemia and Burkitt lymphoma John T. Sandlund and Ian T. Magrath; 19. Acute myeloid leukemia Jeffrey E. Rubnitz, Bassem Razzouk and Raul Ribeiro; 20. Relapsed acute myeloid leukemia Ursula Creutzig; 21. Myelodysplastic syndromes Henrik Hasle; 22. Chronic myeloproliferative disorders Charlotte M. Niemeyer and Franco Locatelli; 23. Hematopoietic stem cell transplantation Rupert Handgretinger, Victoria Turner and Raymond Barfield; 24. Acute leukemia in countries with limited resources Raul Ribeiro, Scott Howard and Ching-Hon Pui; 25. Antibody-targeted therapy Eric L. Sievers and Irwin D. Bernstein; 26. Adoptive cellular immunotherapy Helen E. Heslop and Cliona M. Rooney; 27. Gene therapy: methods and applications Martin Pulè and Malcolm K. Brenner; 28. Minimal residual disease Dario Campana, Andrea Biondi and Jacques J. M. van Dongen; Part IV. Complications and Supportive Care: 29. Acute complications Scott C. Howard, Raul C. Ribeiro and Ching-Hon Pui; 30. Late complications after leukemia therapy Melissa Hudson; 31. Therapy-related leukemias Carolyn A. Felix; 32. Infectious disease complications in leukemia Jeremy A. Franklin and Patricia M. Flynn; 33. Hematologic supportive care Fariba Navid and Victor M. Santana; 34. Pain management Alberto de Armendi and Doraline L. Anghelescu; 35. Psychosocial issues Raymond K. Mulhern, Sean Phipps and Vida L. Tyc; 36. Nursing care Pamela S. Hinds, Jami S. Gattuso and Belinda N. Mandrell.