Brenner and Rector's The Kidney, 2-Volume Set

Overcome the toughest clinical challenges in nephrology with the new 9th edition of Brenner & Rector's The Kidney! A brand-new editorial team of Drs. Maarten W. Taal, Glenn M. Chertow, Philip A. Marsden, Karl Skorecki, Alan S. L. Yu, and Barry M. Brenner,, together with a diverse list of international contributors bring you the latest knowledge and best practices on every front in nephrology worldwide. Brand-new sections on Global Considerations in Nephrology and Pediatric Nephrology, as well as new chapters on recent clinical trials, cardiovascular and renal risk prediction in chronic kidney disease, identification of genetic causes of kidney disease, and many others, keep you at the forefront of this rapidly growing, ever-changing specialty. In print and online at www.expertconsult.com, with regular updates reflecting new developments, Brenner & Rector remains the go-to resource for practicing and training nephrologists and internists who wish to master basic science, pathophysiology, and clinical best practices.

Table of Contents

Section I: Normal Structure and Function &' || 'nbsp; &' || 'nbsp;

Chapter 1&' || 'nbsp; Embryology of the Kidney

Chapter 2 Anatomy of the Kidney

Chapter 3 The Renal Circulations and Glomerular Ultrafiltration

Chapter 4 Metabolic Basis of Solute Transport

Chapter 5 Transport of Sodium, Chloride, and Potassium

Chapter 6 Aldosterone Regulation of Ion Transport

Chapter 7 Transport of Magnesium, Calcium, and Phosphate

Chapter 8 Transport of Organic Solutes

Chapter 9 Renal Acidification Mechanisms

Chapter 10 Urine Concentration and Dilution

Chapter 11 Cell Biology of Vasopressin Action

Chapter 12 Vasoactive Molecules and the Kidney

Chapter 13 Arachidonic Acid Metabolites and the Kidney

Section II: Disorders of Body Fluid Volume and Composition &' || 'nbsp;

Chapter 14 Extracellular Fluid and Edema Formation

Chapter 15 Disorders of Water Balance

Chapter 16 Disorders of Acid-Base Balance

Chapter 17 Disorders of Potassium Balance

Chapter 18 Disorders of Calcium, Magnesium, and Phosphate Balance

Section III: Epidemiology and Risk Factors in Kidney Disease &' || 'nbsp;

Chapter 19 Epidemiology of Kidney Disease

Chapter 20 Demographics of Kidney Disease

Chapter 21 Risk Factors and Kidney Disease

Chapter 22 Nephron Endowment

Chapter 23 Aging and Kidney Disease


Section IV: Evaluation of the Patient with Kidney Disease &' || 'nbsp;

Chapter 24 Approach to the Patient with Kidney Disease

Chapter 25 Laboratory Assessment of Kidney Disease: Glomerular Filtration Rate, Urinalysis, and Proteinuria

Chapter 26 Interpretation of Electrolyte and Acid-Base Parameters in Blood and Urine

Chapter 27 Diagnostic Kidney Imaging

Chapter 28 The Renal Biopsy

Chapter 29 Biomarkers in Acute Kidney Injury and Chronic Kidney Disease

Section V: Disorders of Kidney Structure and Function

&' || 'nbsp;

Chapter 30 Acute Kidney Injury

Chapter 31 Primary Glomerular Disease

Chapter 32 Secondary Glomerular Disease

Chapter 33 Overview of Therapy for Glomerular Disease

Chapter 34 Microvascular and Macrovascular Diseases of the Kidney

Chapter 35 Tubulointerstitial Diseases

Chapter 36 Urinary Tract Infection in Adults

Chapter 37 Urinary Tract Obstruction

Chapter 38 Diabetic Nephropathy

Chapter 39 Nephrolithiasis

Chapter 40 Renal Neoplasia

Chapter 41 Renal Disease in Cancer Patients

Section VI: Genetics of Kidney Disease

Chapter 42 Genetic Basis of Kidney Disease

Chapter 43 Inherited Disorders of the Glomerulus

Chapter 44 Inherited Disorders of the Renal Tubule

Chapter 45 Cystic Diseases of the Kidney

&' || 'nbsp;

Section VII: Hypertension and the Kidney

&' || 'nbsp;

Chapter 46 Primary and Secondary Hypertension

Chapter 47 Renovascular Hypertension and Ischemic Nephropapthy

Chapter 48 Hypertension and Kidney Disease in Pregnancy

Chapter 49 Antihypertensive Drugs

Chapter 50 Diuretics

Section VIII: The Consequences of Advanced Kidney Disease

&' || 'nbsp;

Chapter 51 Adaptation to Nephron Loss

Chapter 52 Mechanisms and Consequences of Proteinuria

Chapter 53 Pathophysiology of Uremia

Chapter 54 Bone and Mineral Disorders in Kidney Disease

Chapter 55 Cardiovascular Aspects of Kidney Disease

Chapter 56 Hematologic Aspects of Kidney Disease

Chapter 57 Endocrine Aspects of Kidney Disease

Chapter 58 Neurologic Complications of Renal Insufficiency

Chapter 59 Dermatologic Conditions in Kidney Disease

Section IX: Conservative Management of Kidney Disease

&' || 'nbsp;

Chapter 60 Diet and Kidney Disease

Chapter 61 Stepped Care Approach to Kidney Disease

Chapter 62 Vitamin D, Calcimimetics, and Phosphate Binders

Chapter 63 Prescribing Drugs in Kidney Disease

Section X: Dialysis and Extracorporeal Therapies

&' || 'nbsp;

Chapter 64 Hemodialysis

Chapter 65 Peritoneal Dialysis

Chapter 66 Intensive Care Nephrology

Chapter 67 Plasmapheresis

Chapter 68 Extracorporeal Treatment of Poisoning

Chapter 69 Interventional Nephrology

Section XI: Kidney Transplantation

&' || 'nbsp;

Chapter 70 Transplantation Immunobiology

Chapter 71 Donor and Recipient Issues

Chapter 72 Clinical Management

Section XII: Pediatric Nephrology

&' || 'nbsp;

Chapter 73 Maturation of Kidney Structure and Function

Chapter 74 Fluid, Electrolyte, and Acid-Base Disorders in Children

Chapter 75 Diseases of the Kidney and Urinary Tract in Children

Chapter 76 Dialysis in Children

Chapter 77 Kidney Transplantation in Children

Section XIII: Global Considerations in Kidney Disease

Chapter 78 Latin America

Chapter 79 Africa

Chapter 80 Near and Middle East

Chapter 81 Indian Subcontinent

Chapter 82 Far East

Chapter 83 Renal Disease in the Oceania Region

Section XIV: Challenges in Nephrology

Chapter 84 Ethical Dilemmas Facing Nephrology: Past, Present, and Future

Chapter 85 Health Disparaties in Nephrology

Chapter 86 Tissue Engineering, Stem Cells, and Cell Therapy in Nephrology


Broaden your knowledge base with expert, dependable, comprehensive answers for every stage of your career from the most comprehensive, definitive clinical reference in the field!

Prepare for certification or recertification with a review of the basic science that underpins clinical nephrology as well as a comprehensive selection of the most important bibliographical sources in nephrology.

Visually grasp and better understand critical information with the aid of over 700 full-color high-quality photographs as well as carefully chosen figures, algorithms, and tables to illustrate essential concepts, nuances of clinical presentation and technique, and decision making.

New to This Edition

Get internationally diverse, trusted guidance and perspectives from a team of well-respected global contributors, all of whom are at the top and the cutting edge of your field. A new editorial team headed by Dr. Taal and hand-picked by Dr. Brenner ensures the ongoing adherence to previous standards of excellence.

Access information quickly thanks to a new, reorganized print format and easily searchable online access to supplemental figures, tables, additional references, and expanded discussions as well as regular online updates, case studies, and more at www.expertconsult.com.

Keep current with the rapid development of care and research worldwide. A new section, "Global Considerations", focuses on regions outside Europe and North America. Leading experts from Latin America, Africa, Near and Middle East, Indian Subcontinent, Far East, Oceania and Australia present their expert insights into specific conditions, as well as progress and challenges in the development of the specialty.

Improve therapy and outcomes for children with renal disease. New to this edition, "Pediatric Nephrology" addresses renal pathologies that usually present in childhood and covers topics such as Maturation of Kidney Structure and Function; Fluid; Electrolyte and Acid-Base Disorders in Children; Diseases of the Kidney and Urinary Tract in Children; Dialysis in Children; and Kidney Transplantation in Children.

Stay up to date with all the latest clinical information including recent clinical trials, genetic causes of kidney disease, and cardiovascular and renal risk prediction in chronic kidney disease.

Published Reviews

"An encyclopedic fountain of knowledge." - JAMA, review of the last edition

"When nephrologic questions arise...use this text first." Mayo Clinic Proceedings, review of the last edition
Author Information
By Maarten W. Taal, MD, FCP(SA), FRCP, Consultant Renal Physician, Renal Dialysis Unit, Derby City General Hospital, Derby, UK; Glenn M. Chertow, MD, MPH, Professor of Medicine, Chief, Division of Nephrology, Stanford University School of Medicine, Stanford, CA, USA; Philip A. Marsden, MD, Professor, Division of Nephrology, University of Toronto, Toronto, Ontario, Canada; Karl Skorecki, MD, Annie Chutick Professor in Medicine, Director, Rappaport Research Institute, Technion-Israel Institute of Technology, Director of Medical and Research Development, Rambam Health Care Center, Haifa, Israel; Alan S. L. Yu, MD, Alan S. L. Yu, MB, BChirHarry Statland and Solon Summerfield Professor of MedicineDirector, Division of Nephrology and Hypertension and the Kidney InstituteUniversity of Kansas Medical Center3901 Rainbow Blvd6018 WHEKansas City, KS 66160-3018 and Barry M. Brenner, MD, AM(Hon), DSc(Hon), DMSc(Hon), FRCP(Lond, Hon), Samuel A. Levine Professor of Medicine, Harvard Medical School, Director, Renal Division; and Senior Physician, Department of Medicine, Brigham and Women's Hospital, Boston, MA