Atlas of Comparative Diagnostic and Experimental Hematology

A vital resource on blood and bone marrow cell morphology in laboratory animal medicine. This fully revised new edition is an essential reference for clinical pathologists in diagnostic laboratories, and medical or veterinary research. The atlas contains over 400 color images of cells from the peripheral blood and bone marrow from a variety of animals encountered in laboratory animal medicine, in health and disease.

Key features:

New chapter on flow cytometry and its application in terms of routine analyses as a means of identifying abnormalities in cell marker expression, which is of particular relevance for pre-clinical safety assessment
Covers the most recent developments in laboratory animal hematology, including parameters measured by the latest generation of analyzers
Coverage of a wide range of laboratory animal species, as well as those used in clinical veterinary trials
Photomicrographs present normal and abnormal blood cells from a variety of hematological conditions along with descriptive text

Foreword.

Introduction.

Dedication.

Acknowledgments.

1 Rodents.

Mouse.

Hamster.

Guinea Pig.

Rat – Sprague Dawley (SD)/Han Wistar (HW).

2 Rabbit.

3 Cat.

4 Dog.

5 Monkey.

Marmoset.

Cynomolgus.

Baboon.

Rhesus Monkey.

6 Other species.

Pig.

Horse.

Goat and Sheep.

Assorted Other Species.

7 Blood collection procedures.

8 Artifacts.

Collection artifacts.

Sample transport and storage.

Anticoagulant.

Storage artifacts.

Blood smear preparation.

Stain precipitate.

References.

9 Bone marrow.

Introduction.

Review of marrow sampling techniques.

Recommended methods for marrow sampling.

Preparation and staining of smears.

Evaluation.

Interpretation.

References.

10 Comparative applications in flow cytometry.

Application of flow cytometry in comparative hematology.

Index.

Clifford Smith is Chief Laboratory Scientist in the Haematology Department, and Head of Logistics, Clinical Pathology Services, at Covance Laboratories in Harrogate, UK.

Alfred Jarecki is Principal Research Scientist with Sanofi-Aventis at the Alnwick Research Centre, UK.