Assisted Reproductive Technology: Accomplishments and New Horizons

This insightful and thought-provoking collection of chapters describes the rapid advances that have revolutionised reproductive medicine. This transformation is the result of converging and overlapping developments in reproductive biology, molecular biology and genetics. These advances allied with remarkable technical developments are pushing the boundaries of this discipline ever faster forward. This volume surveys this rapid expansion and looks ahead at exciting new prospects for the future that stand at the watershed between basic science and clinical application. From oogeneis and spermatogenesis, through to fertilisation, embryogenesis, and cloning, this volume looks at cutting-edge technologies and scientific advances. Subsequent chapters focus on infertility and its diagnosis and treatment using the full armory of assisted reproductive technologies. A concluding section surveys the impact of these developments on the provision, regulation and financing of reproductive health care in the global community.

• Presents a comprehensive review of the field of ART • Includes important coverage of future developments and prospects • Written by leading international authorities

Contents
Foreword Howard W. Jones; Part I. The Gametes: Present and Future: 1. Spermatogenesis in vitro in mammals Bernard Jégou, Charles Pineau and Jorma Toppari; 2. The spermatozoon as a machine J. Travis and Gregory Kopf; 3. Attributes of fertile spermatozoa Christopher De Jonge and Christopher L. R. Barratt; 4. In vitro oogenesis Frank L. Barnes; 5. The oocyte as a machine Kate Hardy; 6. Epigenetic influences on human oocyte and embryo development Jonathan Van Blerkom; 7. Unresolved and basic problems in assisted reproductive technology Jim Cummins; Part II. Techniques: Present and future: 8. Influences of culture media on embryo development Barry Bavister and Jay Baltz; 9. Cryopreservation of immature and mature gametes John K. Critser, Yuksel Agca and Erik J. Woods; 10. Embryonic stem cells Ann M. Lawler and John D. Gearhart; 11. Modification of the male genome by gene and spermatogonial transplantation Peter J. Donovan, Michael D. Griswold and Lonnie D. Russell; 12. Genetic diagnosis - the future David Cram and David de Kretser; 13. Cloning mammals Don P. Wolf and Shoukhrat Mitalipov; 14. Fluorescence imaging: gamete selection and ICSI L. Hewitson, C. Simerly and G. Schatten; Part III. The Clinic: 15. Diagnosis and treatment of male infertility A. Kamischke and E. Nieschlag; 16. Tests of male fertility R. John Aitken; 17. Diagnosis and treatment for female subfertility Peter Platteau and Paul Devroey; 18. Advances in ultrasound imaging Richard P. Dickey and Ellen Matulich; 19. The natural cycle vs stimulated cycle Ian D. Cooke; 20. Embryo stage and transfer number Alan Trounson; 21. The national institutes of health and the research base for improving the outcomes of ART Donna L. Vogel; Part IV. Concepts for the Global Community: 22. From conception to contraception Gustavo F. Doncel, Christine Mauck, Douglas S. Colvard and Lourens J. D. Zaneveld; 23. Developing immunocontraceptives Eileen A. McLaughlin and Michael K. Holland; 24. ARTistic license: should assisted reproductive technologies be regulated? Nanette R. Elster; 25. Finances and access to ART: justice and publication of results F. Shenfield; 26. Sex selection Joe Leigh Simpson and Sandra Ann Carson; 27. ICSI: a time bomb? Herman J. Tournaye and André C. Van Steirteghem; 28. Cryopreservation of gametes and embryos - legal and ethical aspects Susan M. Avery and Peter R. Brinsden; Index.

Reviews
‘The editors have done an excellent job of producing a topical and authoritative work that is simultaneously a joy to read … Provocative treatises interspersed with technical ones maintain reader attention, an effective editorial tool.’ Journal of Andrology

‘This book provides an authoritative account of current knowledge in the field of human reproductive biology and assisted conception.’ The Obstetrician & Gynaecologist

Contributors
Howard W. Jones, Bernard Jégou, Charles Pineau, Jorma Toppari, Alexander J. Travis, Gregory Kopf, Christopher De Jonge, Christopher L. R. Barratt, Frank L. Barnes, Kate Hardy, Jonathan Van Blerkom, Jim Cummins, Barry Bavister, Jay Baltz, John K. Critser, Yuksel Agca, Erik J. Woods, Ann M. Lawler, John D. Gearhart, Peter J. Donovan, Michael D. Griswold, Lonnie D. Russell, David Cram, David de Kretser, Don P. Wolf, Shoukhrat Mitalipov, L. Hewitson, C. Simerly, G. Schatten, A. Kamischke, E. Nieschlag, R. John Aitken, Peter Platteau, Paul Devroey, Richard P. Dickey, Ellen Matulich, Ian D. Cooke, Alan Trounson, Donna L. Vogel, Gustavo F. Doncel, Christine Mauck, Douglas S. Colvard, Lourens J. D. Zaneveld, Eileen A. McLaughlin, Michael K. Holland, Nanette R. Elster, F. Shenfield, Joe Leigh Simpson, Sandra Ann Carson, Herman J. Tournaye, André C. Van Steirteghem, Susan M. Avery, Peter R. Brinsden.