Adult Acute Lymphocytic Leukemia: Biology and Treatment

The current explosion of new areas of controversy in the treatment of acute lymphocytic leukemia in adults and young adults makes this comprehensive book a much needed reference for hematologists and oncologists. This book assembles leading authorities from around the globe to cover the full spectrum of ALL subtypes and their treatments. Specific topics of discussion include indications for allogeneic bone marrow transplant in first complete remission, the role of minimal residual disease in making treatment decisions, the treatment of young adults, and the treatment of Philadelphia chromosome positive ALL with the advent of the tyrosine kinase inhibitors. This is the first book to focus exclusively on the adult ALL patient. It provides a complete overview of diagnosis, molecular pathogenesis, evaluation, and treatment for this important patient population.


Table of contents Chapter 1 A Perspective on the Treatment of Acute Lymphoblastic Leukemia Charles A Schiffer Chapter 2 Clinical Features and Making the Diagnosis Olga Frankfurt LoAnn Peterson Martin S. Tallman Chapter 3 The Biology of Adult Acute Lymphoblastic Leukemia Jerald Radich Olga Sala Chapter 4 Minimal Residual Disease in Acute Lymphoblastic Leukemia Patrick A. Zweidler-McKay Michael J. Borowitz Chapter 5 Cytogenetics Anthony V. Moorman Christine J. Harrison Chapter 6 Acute Lymphoblastic leukemia: Epidemiology Matthew Hourigan Anthony H. Goldstone Chapter 7 Prognostic Factors in Acute Lymphoblastic Leukemia Adele K. Fielding Chapter 8 The Generalized Care of the Patient with Acute Lymphoblastic Leukemia Anthony R. Mato Alicia K. Morgans Selina M. Luger Chapter 9 Treatment of Acute Lymphoblastic Leukemia in Middle-Age and Older Adults Vaishalee Kenkre Richard A. Larson Chapter 10 Pharmacology of Acute Lymphoblastic Leukemia Therapy Paul M. Barr Richard J. Creger Nathan A. Berger Chapter 11 Assessment of Response to Treatment Christopher A. Fox A.K. McMillan Chapter 12 T-cell Acute Lymphoblastic Leukemia Andrei R. Shustov Frederick R. Appelbaum Chapter 13 Burkitt Leukemia and Lymphoma Kevin A. David Mark Roberts LoAnn Peterson Andrew M. Evens Chapter 14 Treatment of Acute Lymphoblastic Leukemia in Young Adults Nicolas Boissel Francoise Huguet Herve Dombret Chapter 15 Treatment of Philadephia Chromosome Positive Acute Lymphoblastic Leukemia Deborah Thomas Chapter 16 Molecular Therapies Camille Abboud Chapter 17 Treatment of Relapsed/ Refractory Acute Lymphoblastic Leukemia Dan DeAngelo Chapter 18 Allogenic Stem Cell Transplantation for Acute Lymphoblastic Leukemia in Adults David I. Marks Chapter 19 Hematopoietic Stem Cell Transplantation in Philadelphia-positive Acute Lymphoblastic Leukemia Christy J. Stotler Edward Copelan Chapter 20 Special Challenges: Genetic polymorphisms and therapy Maja Krainovic Chapter 21 Late Consequences of Therapy of Acute Lymphoblastic Leukemia Mark R. Litzow Chapter 22 Immunotherapy for Acute Lymphocytic Leukemia Jacalyn Rosenblatt David Avigan Chapter 23 Unique Subtypes in Acute Lymphoblastic Leukemia Elisabeth Paietta